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公开(公告)号：WO2007092414A2
公开(公告)日：2007-08-16
申请号：PCT/US2007003095
申请日：2007-02-06
发明人： ZHUANG ZHENGPING , OLDFIELD EDWARD H , PARK DERIC M , LUBENSKY IRINA , LI JIE , KOVACH JOHN S
CPC分类号： A61K31/519
摘要： This invention provides a method of treating a patient suffering from a tumor overexpressing N-CoR comprising administering to the patient a phosphatase ligand, alone or in combination with "a retinoid receptor ligand, a histone deacetylase ligand, or both, in amounts effective to treat the patient. This invention also provides a method of inhibiting tumor growth in a patient suffering from a tumor overexpressing N-CoR. This invention further provides a method of identifying a compound or a mixture of compounds capable of inducing differentiation of cells of a tumor overexpressing N- CoR. This invention still further provides a method of determining the likelihood of successfully treating a subject suffering from a tumor overexpressing N-CoR. This invention also provides a method of assessing the- likelihood that a patient is suffering from a tumor overexpressing N-CoR. This invention yet also provides a method of assessing the likelihood that a patient previously suffering from and treated for a tumor overexpressing N-CoR has suffered a recurrence of a tumor overexpressing N-CoR. Finally, this invention provides analogous methods for use on glioblastoma multiforme.
摘要翻译： 本发明提供一种治疗患有过度表达N-CoR的肿瘤患者的方法，包括向患者施用磷酸酶配体，其单独或与“类视黄醇受体配体，组蛋白脱乙酰酶配体”或两者联合使用，其量有效治疗 本发明还提供了一种抑制患有过表达N-CoR的肿瘤患者的肿瘤生长的方法，本发明还提供了鉴定能够诱导过度表达的肿瘤的细胞分化的化合物或化合物的混合物的方法 本发明还提供了确定成功治疗患有肿瘤过表达N-CoR的受试者的可能性的方法，本发明还提供了评估患者患有过表达N型肿瘤的可能性的方法 -CoR。本发明还提供了一种评估先前患有和患有这种疾病的患者的可能性的方法 选择过度表达N-CoR的肿瘤已经复发了过度表达N-CoR的肿瘤。 最后，本发明提供了用于多形性成胶质细胞瘤的类似方法。
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公开(公告)号：WO2008097561A8
公开(公告)日：2009-10-01
申请号：PCT/US2008001549
申请日：2008-02-06
发明人： KOVACH JOHN S , JOHNSON FRANCIS
CPC分类号： C07D493/08 , A61K31/203 , A61K31/496
摘要： This invention provides compounds having the structure which may be used for the treatment of tumors.
摘要翻译： 本发明提供具有可用于治疗肿瘤的结构的化合物。
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公开(公告)号：WO2007092414A8
公开(公告)日：2008-09-04
申请号：PCT/US2007003095
申请日：2007-02-06
发明人： ZHUANG ZHENGPING , OLDFIELD EDWARD H , PARK DERIC M , LUBENSKY IRINA , LI JIE , KOVACH JOHN S
IPC分类号： A61K31/00
CPC分类号： A61K31/519
摘要： This invention provides a method of treating a patient suffering from a tumor overexpressing N-CoR comprising administering to the patient a phosphatase ligand, alone or in combination with "a retinoid receptor ligand, a histone deacetylase ligand, or both, in amounts effective to treat the patient. This invention also provides a method of inhibiting tumor growth in a patient suffering from a tumor overexpressing N-CoR. This invention further provides a method of identifying a compound or a mixture of compounds capable of inducing differentiation of cells of a tumor overexpressing N- CoR. This invention still further provides a method of determining the likelihood of successfully treating a subject suffering from a tumor overexpressing N-CoR. This invention also provides a method of assessing the- likelihood that a patient is suffering from a tumor overexpressing N-CoR. This invention yet also provides a method of assessing the likelihood that a patient previously suffering from and treated for a tumor overexpressing N-CoR has suffered a recurrence of a tumor overexpressing N-CoR. Finally, this invention provides analogous methods for use on glioblastoma multiforme.
摘要翻译： 本发明提供一种治疗患有过度表达N-CoR的肿瘤患者的方法，包括向患者施用磷酸酶配体，其单独或与“类视黄醇受体配体，组蛋白脱乙酰酶配体”或两者联合使用，其量有效治疗 本发明还提供了一种抑制患有过表达N-CoR的肿瘤患者的肿瘤生长的方法，本发明还提供了鉴定能够诱导过度表达的肿瘤的细胞分化的化合物或化合物的混合物的方法 本发明还提供了确定成功治疗患有肿瘤过表达N-CoR的受试者的可能性的方法，本发明还提供了评估患者患有过表达N型肿瘤的可能性的方法 -CoR。本发明还提供了一种评估先前患有和患有这种疾病的患者的可能性的方法 选择过度表达N-CoR的肿瘤已经复发了过度表达N-CoR的肿瘤。 最后，本发明提供了用于多形性成胶质细胞瘤的类似方法。
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