公开(公告)号：WO2014153661A1

公开(公告)日：2014-10-02

申请号：PCT/CA2014/050312

申请日：2014-03-26

Applicant: LONDON HEALTH SCIENCES CENTRE RESEARCH INC.

Inventor： LEONG, Hon Sing ,  LUYT, Leonard ,  BIGGS, Colleen Nicole ,  ST. AMANT, Andre ,  LEWIS, John D. ,  MINUK, Leonard

IPC: C09K11/07 ,  G01N33/48 ,  G01N33/483 ,  G01N33/49 ,  G01N33/50 ,  G01N33/52

CPC classification number: G01N33/84 ,  C09B11/08 ,  C09B23/083 ,  G01N33/582 ,  G01N2800/108 ,  G01N2800/52 ,  G01N2800/56

Abstract: Methods for identifying subjects having bone loss by detecting bone microparticles in a sample of their bodily fluid are disclosed. Methods for monitoring bone loss and assessing efficacy of bone loss therapies by detecting bone microparticles in bodily fluid samples are also disclosed. Compounds for use as a negative control in the disclosed methods are provided as well as kits comprising such compounds.

Abstract translation: 公开了通过检测其体液样品中的骨微粒来识别具有骨丢失的受试者的方法。 还公开了通过检测体液样品中的骨微粒来监测骨丢失和评估骨损失疗法的功效的方法。 提供了在所公开的方法中用作阴性对照的化合物以及包含这些化合物的试剂盒。