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    DIAGNOSTIC AND THERAPY OF TRAUMATIC BRAIN INJURY
    1.
    发明申请
    DIAGNOSTIC AND THERAPY OF TRAUMATIC BRAIN INJURY 审中-公开

    公开(公告)号：WO2022082318A1

    公开(公告)日：2022-04-28

    申请号：PCT/CA2021/051493

    申请日：2021-10-22

    申请人： LONDON HEALTH SCIENCES CENTRE RESEARCH INC.

    发明人： FRASER, Douglas

    IPC分类号： G01N33/48 ,  C12Q1/6804 ,  G01N33/53 ,  G01N33/543 ,  G01N33/558 ,  G01B40/00

    摘要： A method of diagnosing and prognosticating an acquired central nervous system injury (ACNSI) in a subject that includes: (a) obtaining a test sample from the subject (b) comparing levels a biomarker in the test sample with known normal or abnormal reference levels of the biomarker. A change (increase or decrease) in the levels of the biomarker in the test sample relative to the known reference levels of the biomarker is indicative of ACNSI diagnosis in the subject, the biomarker being one or a combination of two or more of the proteins listed in Table 2. ACNSI includes concussion and primary blast in blast-induced traumatic brain injury.

    DETERMINING CENTRAL NERVOUS SYSTEM INJURY AND RECOVERY
    2.
    发明申请
    DETERMINING CENTRAL NERVOUS SYSTEM INJURY AND RECOVERY 审中-公开

    公开(公告)号：WO2021179086A1

    公开(公告)日：2021-09-16

    申请号：PCT/CA2021/050331

    申请日：2021-03-11

    申请人： LONDON HEALTH SCIENCES CENTRE RESEARCH INC.

    发明人： FRASER, Douglas

    IPC分类号： G01N33/48 ,  G16B99/00

    摘要： A method of diagnosing acquired CNS injury (ACNSI) in a subject comprising: (a) obtaining a test sample from the subject (b) comparing levels of a lipid species or a cohort of multiple lipid species in the test sample with the levels of the single lipid species or the cohort of multiple lipid species in a control sample, or comparing to a normal reference range, (i.e. non- ACNSI (referred to as "normal") subjects) using quantitative measurements, wherein a change (i.e. a drop or an increase) in the level of the lipid species or the cohort of multiple lipid species in the test sample relative to the control sample is indicative of ACNSI in the subject.

    METABOLOMICS PROFILING OF CENTRAL NERVOUS SYSTEM INJURY
    3.
    发明申请
    METABOLOMICS PROFILING OF CENTRAL NERVOUS SYSTEM INJURY 审中-公开
    中枢神经系统损伤的代谢物分析

    公开(公告)号：WO2016149808A1

    公开(公告)日：2016-09-29

    申请号：PCT/CA2016/050310

    申请日：2016-03-18

    申请人： LONDON HEALTH SCIENCES CENTRE RESEARCH INC.

    发明人： FRASER, Douglas Dale ,  BARTHA, Robert ,  BROWN, Arthur ,  STEWART, Tanya Charyk ,  DALEY, Mark ,  DEKABAN, Greg A. ,  DOHERTY, Timothy ,  FISCHER, Lisa ,  HOLMES, Jeff ,  MENON, Ravi ,  RUPAR, Tony

    IPC分类号： G01N33/48 ,  A61B5/00 ,  G01N33/483 ,  G06F15/18 ,  G06F19/00

    CPC分类号： G01N33/487 ,  G01N24/08 ,  G01N33/483 ,  G01N33/6896 ,  G01N2570/00 ,  G01N2800/28 ,  G01N2800/2871 ,  G06F19/24

    摘要： A method of diagnosing central nervous system injuries such as acquired brain injury (ABI) and/or acquired spinal cord injury (ASI), including mild TBI (concussion or blast wave), mild ASI (contusion, stretch or partial cord transection), non-TBI brain injury and/or non-TSI spinal cord injury in a subject (animal or human). The method includes (a) obtaining a biological test sample from the subject, identifying metabolites in the subject's sample using metabolomics thereby obtaining a subject's metabolite matrix and generating a subject's profile using the patient's metabolite matrix; and (b) using multivariate statistical analysis and machine learning to compare the subject's profile with predetermined set of profiles of CNS injuries and a predetermined set of profiles of controls to determine if the subject has a CNS injury.

    摘要翻译： 诊断中枢神经系统损伤的方法，例如获得性脑损伤（ABI）和/或获得性脊髓损伤（ASI），包括轻度TBI（脑震荡或冲击波），轻度ASI（挫伤，拉伸或部分线切断），非 -TBI脑损伤和/或受试者（动物或人）中的非TSI脊髓损伤。 该方法包括（a）从受试者获得生物测试样品，使用代谢组学鉴定受试者样品中的代谢物，从而获得受试者的代谢物基质并使用患者的代谢物基质产生受试者的分布; 和（b）使用多变量统计分析和机器学习来比较受试者的轮廓与CNS损伤的预定组合和预定的对照组，以确定受试者是否具有CNS损伤。

    EXPANDABLE CELL POPULATIONS FROM BRAIN BIOPSIES OF LIVING SUBJECTS
    4.
    发明申请
    EXPANDABLE CELL POPULATIONS FROM BRAIN BIOPSIES OF LIVING SUBJECTS 审中-公开
    可生殖细胞群体来自生殖器官生物

    公开(公告)号：WO2014183220A1

    公开(公告)日：2014-11-20

    申请号：PCT/CA2014/050461

    申请日：2014-05-16

    申请人： LONDON HEALTH SCIENCES CENTRE RESEARCH INC.

    发明人： HEBB, Matthew Olding

    IPC分类号： C12N5/079 ,  A61K35/30 ,  A61P25/00 ,  C12N5/07 ,  C12N5/077 ,  C12N5/10 ,  C12Q1/04

    CPC分类号： C12N5/0618 ,  A61K35/30 ,  C12N2510/00 ,  C12N2533/32 ,  G01N33/5005

    摘要： The present invention relates to a method of producing expandable cultured brain cells. The brain cells are neurotrophic factor (NTF) positive. The expandable cultured brain cells are obtained by culturing a biopsy obtained from the cortical and/or subcortical brain region of a living subject. The biopsies can be obtained during neurosurgical procedures such as deep brain stimulation. The expandable cultured brain cells of the present invention are useful for the treatment of neurological diseases and other medical conditions.

    摘要翻译： 本发明涉及一种生产可扩张培养的脑细胞的方法。 脑细胞是神经营养因子（NTF）阳性。 通过培养从活体受试者的皮层和/或皮质下脑区域获得的活检获得可扩张培养的脑细胞。 活检可以在神经外科手术中获得，如深部脑刺激。 本发明的可扩张培养的脑细胞可用于治疗神经疾病和其他医学病症。

    HANDS-FREE POINTER SYSTEM
    6.
    发明申请
    HANDS-FREE POINTER SYSTEM 审中-公开
    无手指系统

    公开(公告)号：WO2010057304A1

    公开(公告)日：2010-05-27

    申请号：PCT/CA2009/001667

    申请日：2009-11-20

    申请人： LONDON HEALTH SCIENCES CENTRE RESEARCH INC. ,  SCHLACHTA, Christopher, M. ,  PATEL, Rajnikant, V. ,  TREJOS, Ana, Luisa ,  NAISH, Michael, David

    发明人： SCHLACHTA, Christopher, M. ,  PATEL, Rajnikant, V. ,  TREJOS, Ana, Luisa ,  NAISH, Michael, David

    IPC分类号： G06F3/03 ,  G06F3/042 ,  G09B5/02 ,  G10L15/00

    CPC分类号： G06F3/012 ,  A61B1/00039 ,  G06F3/011 ,  G06F3/0346

    摘要： The present invention describes a hands-free system for controlling the movement of a cursor on one or more display devices. A tracking device including a traceable marker and one or more accelerometers and gyroscopes are used to track position and acceleration of the marker relative to a target of interest. A processing means processes the motion signals from the tracking device to determine the location of the cursor on the operator's monitor, which may also be displayed on more monitors. The tracking device is worn by the operator, optimally on the operator's head. The operator's head movements determine movement of the cursor.

    摘要翻译： 本发明描述了一种用于控制光标在一个或多个显示设备上的移动的免提系统。 使用包括可跟踪标记和一个或多个加速度计和陀螺仪的跟踪装置跟踪相对于感兴趣的目标的标记的位置和加速度。 处理装置处理来自跟踪装置的运动信号以确定光标在操作员监视器上的位置，其也可以显示在更多的监视器上。 跟踪装置由操作者佩戴，最佳地在操作人员的头上。 操作者的头部移动确定光标的移动。

    DNA METHYLATION ASSAYS AND METHODS
    8.
    发明申请
    DNA METHYLATION ASSAYS AND METHODS 审中-公开

    公开(公告)号：WO2019195941A1

    公开(公告)日：2019-10-17

    申请号：PCT/CA2019/050444

    申请日：2019-04-12

    申请人： LONDON HEALTH SCIENCES CENTRE RESEARCH INC.

    发明人： SADIKOVIC, Bekim ,  AREF ESHGHI, Erfan

    IPC分类号： C12Q1/6809 ,  C12Q1/68 ,  C12Q1/6886

    摘要： A method for diagnosing prostate cancer in a subject, the method comprises measuring the methylation level of at least one CpG locus in a sample from the subject, wherein the at least one CpG locus is selected from the loci listed in Table 1 and/or is within about 1000, 900, 800, 700, 600, 500, 400, 300, 200, or 100 nucleotides of at least one of the loci listed in Table 1; and determining the level of similarity between the measured methylation level and a predefined level indicative of prostate cancer, wherein a high degree of similarity between the measured methylation level and the predefined level indicates the presence or increased likelihood of prostate cancer.