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公开(公告)号：WO2022144136A1
公开(公告)日：2022-07-07
申请号：PCT/EP2021/083379
申请日：2021-11-29
摘要： The disclosure relates to core-shell nanoparticle, the nanoparticle comprising a core being one or more selected from vaterite, proto-vaterite, and amorphous calcium carbonate as determined by X-Ray diffraction, remarkable in that the nanoparticle further comprises a shell of polyphenol, wherein said polyphenol is selected to be insoluble in water, to show a pH ranging from 5 to 9 when measured in a solution of one or more polar solvents and water at a concentration of 10 wt.% based on the total weight of said solution and wherein said polyphenol is at least partially soluble in said one or more polar solvents. A method for forming such nanoparticle as well as their use and the use of polyphenol as shell of shell-core nanoparticle is also described.
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2.发明申请
公开(公告)号：WO2019057786A1
公开(公告)日：2019-03-28
申请号：PCT/EP2018/075370
申请日：2018-09-19
摘要： The invention is directed to a method for producing a gas sensor (2) comprising a step of providing a substrate (4) with two coplanar electrodes (6) and a step of forming a ZnO nanowires network (8) on said two electrodes (6). The step of forming a ZnO nanowires network (8) on said two electrodes (6) is performed as follows: synthesizing ZnO nanowires with a liquid phase sequential growth method; dispersing said synthetized nanowires in a solvent; drop casting the solution containing the solvent and the ZnO nanowires on the electrodes; drying the solution at a temperature inferior to 85°C. The invention is also directed to a gas sensor working at low temperature such as room temperature.
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3.发明申请NEGATIVELY CHARGED SELF-ASSEMBLING SUPPORTED LIPID BILAYER ON MESOPOROUS SILICA NANOPARTICLES, METHOD OF SYNTHESIS AND USE AS A NANOVECTOR 审中-公开在多孔二氧化硅纳米粒子上自负荷自组装支持的双面胶体，合成方法和用作纳米线
公开(公告)号：WO2017013250A1
公开(公告)日：2017-01-26
申请号：PCT/EP2016/067546
申请日：2016-07-22
CPC分类号： A61K9/127 , A61K9/1271 , A61K9/1277 , A61K9/5115
摘要： The invention is directed to a method for manufacturing a negatively charged supported lipid bilayer. Said method comprises the steps of preparing a formulation comprising at least three lipids (1,2-dioleoyl-sn-glycero-3-phospho-L- serine (DOPS), cholesterol and at least one lipid different from DOPS and cholesterol) dissolved in a first solvent, of evaporating said first solvent, of adding an aqueous formulation of mesoporous silica nanoparticles, of performing an ultra- sonication and of performing a centrifugation. Said method is remarkable in that the number of equivalents of cholesterol relative to one equivalent of DOPS is comprised between 2.30 and 2.70. The invention is further directed to negatively charged supported lipid bilayer on a mesoporous silica nanoparticle comprising cholesterol, 1,2-dioleoyl-sn-glycero-3-phospho-L-serine (DOPS) and at least one lipid different from DOPS and cholesterol.
摘要翻译： 本发明涉及制造带负电荷的脂质双层的方法。 所述方法包括以下步骤：制备包含至少三种脂质（1,2-二油酰-sn-甘油-3-磷酸-L-丝氨酸（DOPS）），胆固醇和至少一种不同于DOPS和胆固醇的脂质） 蒸发所述第一溶剂的第一溶剂，加入介孔二氧化硅纳米颗粒的水性制剂，进行超声处理和进行离心。 所述方法是显着的，因为胆固醇相对于1当量的DOPS的当量数在2.30和2.70之间。 本发明进一步涉及包含胆固醇，1,2-二油酰-sn-甘油-3-磷酸-L-丝氨酸（DOPS）和至少一种不同于DOPS和胆固醇的脂质的介孔二氧化硅纳米颗粒上带负电荷的支持脂质双层。
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公开(公告)号：WO2022144135A1
公开(公告)日：2022-07-07
申请号：PCT/EP2021/083361
申请日：2021-11-29
IPC分类号： C09C1/02
摘要： The disclosure relates to lipid-coated calcium carbonate nanoparticles, said nanoparticles comprising an outer layer and a core being calcium carbonate nanoparticle, wherein said core is vaterite, proto-vaterite, or amorphous calcium carbonate as determined by X-Ray diffraction, wherein said core is at least partially coated with one or more amphiphilic compounds eachhaving one hydrophilic head and at least one hydrophobic tail, remarkable in that the hydrophilic heads are negatively charged and form the outer layer of the nanoparticles, in that the nanoparticles have a surface charge having a zeta-potential below 0 mV as determined bymicro-electrophoretic light scattering technology and in that said one or more amphiphilic compounds are PEG-free. The disclosure also relates to methods for forming suchnanoparticles, for modulating the electrical charge of such nanoparticles as well as to the uses of such nanoparticles.
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公开(公告)号：WO2022073858A1
公开(公告)日：2022-04-14
申请号：PCT/EP2021/077055
申请日：2021-10-01
摘要： The disclosure relates to a method for manufacturing a colloidal dispersion of Kraft lignin (KL) nanoparticles, said method comprising the steps of (a) providing KL; (b) dissolving said KL into a solvent, to obtain a solution having a concentration of Kraft lignin of at least 15 mg/ml; and (c) mixing said solution with an antisolvent under mixing conditions, to provide a colloidal dispersion of nanoparticles. Said method is remarkable in that the solvent used in step (b) of dissolving said KL is one or more organic solvents, and in that step (c) of mixing is performed by the addition of the solution of step (b) into an antisolvent being or comprising water. The disclosure also relates to spherical KL nanoparticles with an average diameter size ranging from 9 nm up to 70 nm. The disclosure further relates to various uses of said spherical KL nanoparticle.
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6.发明申请HIGHLY AMINATED SELF-ASSEMBLING FUNCTIONALIZED MESOPOROUS SILICA NANOPARTICLES AND METHOD OF SYNTHESIS 审中-公开高分子自组装功能化的多孔二氧化硅纳米粒子及其合成方法
公开(公告)号：WO2017013182A1
公开(公告)日：2017-01-26
申请号：PCT/EP2016/067327
申请日：2016-07-20
IPC分类号： C01B37/02
CPC分类号： C01B37/02
摘要： The invention is directed to a method for self-assembling a mesoporous silica nanoparticle. Said method comprises the step of condensing a silica precursor, a surfactant and a condensation agent in a solvent. Then, the addition of an organotriethoxysilane is performed. Finally, there is the step of removing said surfactant. Said method is remarkable in that the portion of said organotriethoxysilane to said silica precursor is comprised between 5% and 15%. The invention is further directed to a self-assembled mesoporous silica nanoparticle comprising at least one silica precursor and an organotriethoxysilane.
摘要翻译： 本发明涉及一种自组装介孔二氧化硅纳米颗粒的方法。 所述方法包括将二氧化硅前体，表面活性剂和缩合剂在溶剂中缩合的步骤。 然后，加入有机三乙氧基硅烷。 最后，有去除所述表面活性剂的步骤。 所述方法是显着的，因为所述有机三乙氧基硅烷对所述二氧化硅前体的部分为5％至15％。 本发明还涉及包含至少一种二氧化硅前体和有机三乙氧基硅烷的自组装介孔二氧化硅纳米颗粒。
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公开(公告)号：WO2016038161A1
公开(公告)日：2016-03-17
申请号：PCT/EP2015/070759
申请日：2015-09-10
CPC分类号： A61N1/05 , A61L27/306 , A61L2430/32 , A61N1/37
摘要： According to the present invention, an implantable device comprising an electrode for carrying an electric signal to or from a biological cell or tissue provided. The electrode material is chosen to exhibit desirable properties in terms of electrical conductivity, biocompatibility and bio-fouling. The invention further provides implantable devices comprising such implantable electrodes.
摘要翻译： 根据本发明，一种可植入装置，其包括用于向生物细胞或组织提供电信号的电极。 选择电极材料在电导率，生物相容性和生物污损方面表现出期望的性质。 本发明还提供了包括这种可植入电极的可植入装置。
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8.发明申请
公开(公告)号：WO2019122124A1
公开(公告)日：2019-06-27
申请号：PCT/EP2018/086189
申请日：2018-12-20
IPC分类号： A61K41/00
摘要： The invention is directed to a method for manufacturing mesoporous silica nanoparticles with encapsulated superparamagnetic clusters, said method comprising the nudeation of superparamagnetic particles and the condensation of silica in order to wrap those superparamagnetic particles. The control of the number of superparamagnetic clusters is regulated by the addition of the cationic surfactant. Methods for encapsulating said nanoparticles with a negatively charged supported lipid bilayer and with an additional outer layer are also described.
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公开(公告)号：WO2018134222A1
公开(公告)日：2018-07-26
申请号：PCT/EP2018/051060
申请日：2018-01-17
摘要： The invention is directed to a method for manufacturing supported lipid bilayer on a porous silica nanoparticle with a ζ-potential comprised between -10 mV and +10 mV, said method comprising the steps of (a) providing a negatively charged supported lipid bilayer on a porous silica nanoparticle, wherein said negatively charged supported lipid bilayer has a ζ-potential inferior to -15 mV and wherein said negatively charged supported lipid bilayer comprised at least one phospholipid and; (b) adding a formulation of lipids, said lipids being 1,2-dioleoyl-3-trimethylammonium-propane alias DOTAP, cholesterol and at least one lipid different from DOTAP and cholesterol. Said method is remarkable in that it further comprises the step of (c) performing an ultra-sonication for promoting DOTAP incorporation. Said method can be supplemented by the step of addition of alginate and the step of cross-linking said alginate. The invention is also directed to nanocapsule and composition comprising said nanocapsule.
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10.发明申请
公开(公告)号：WO2016038158A1
公开(公告)日：2016-03-17
申请号：PCT/EP2015/070754
申请日：2015-09-10
CPC分类号： A61L27/306 , A61B5/04001 , A61B5/686 , A61L2400/18 , A61L2430/32 , A61N1/3605 , A61N1/375 , H01L21/3065 , H01L29/2003
摘要： According to the present invention, an implantable device is provided, comprising a substrate on which at least one surface portion is provided. The chemical composition of the surface portion selectively enhances the cell-adhesion to the substrate.
摘要翻译： 根据本发明，提供了一种可植入装置，其包括其上设置有至少一个表面部分的基底。 表面部分的化学组成选择性地增强了与基材的电池粘附。
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