公开(公告)号：WO2015161841A2

公开(公告)日：2015-10-29

申请号：PCT/DE2015000204

申请日：2015-04-22

Applicant: MARTIN LUTHER UNIVERSITÄT HALLE WITTENBERG

Inventor： MÄDER KARSTEN ,  WEISS VERENA ,  KRESSLER JÖRG ,  NAOLOU TOUFIK

CPC classification number: A61K47/34 ,  A61K9/0019 ,  A61K9/0024 ,  A61K9/146 ,  A61K31/4422 ,  A61K31/573 ,  A61K47/10 ,  C08G63/00 ,  C08G63/914

Abstract: The problem addressed by the invention was to show an alternative to the previously clinically used biodegradable polymers based on monomers having a hydroxycarboxylic acid structure. This problem was solved according to the invention by means of linear polyesters that are produced by esterifying dicarboxylic acids and multivalent alcohols (diols, trioles, or higher-valency alcohols) (figure 1). It was found that modified poly(dicarboxylic acid multi-oil esters) without further additives are suitable as injectable implants. The polymers can be directly injected without using an organic solvent. Furthermore, it was found that modified poly(dicarboxylic acid multi-oil esters) can be mixed with and injected with suitable biocompatible organic solvents or preformed as an implant. The carrier systems are used for the controlled release of active ingredient in human and veterinary medicine.

Abstract translation: 本发明的目的是展示一种替代基于与Hydroxykarbonsäurestruktur单体先前临床使用的可生物降解的聚合物。 该问题按本发明通过线性聚酯由二羧酸和多元醇（二醇，三醇或高级醇）产生（图1）的酯化来解决。 已经发现，改性的聚（二羧酸酯multiol）适合不经进一步增补注射植入物。 在此，聚合物可以直接在不使用有机溶剂注入。 此外，人们发现，改性的聚（二羧酸multiol酯）可与合适的生物相容的有机溶剂进行混合并注入预先形成或作为植入物。 为活性成分的人用和兽用药物控释利用运载系统。