公开(公告)号：WO2016077079A1

公开(公告)日：2016-05-19

申请号：PCT/US2015/058120

申请日：2015-10-29

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Inventor： LU, Timothy, Kuan-Ta ,  CARR, Peter, A. ,  ZAKERI, Bijan

IPC: G06F21/00

CPC classification number: H04L9/06 ,  C12Q1/68 ,  C12Q1/6869 ,  G09C1/00 ,  H04L9/00 ,  H04L9/0656 ,  H04L9/0866 ,  C12Q2563/185

Abstract: In some aspects, the instant disclosure relates to the multiplexed encryption of information on nucleic acid molecules. In some aspects, the instant disclosure relates to a method of secure communication of information disseminated across at least one nucleic acid molecule, the method comprising (a) obtaining a modified keyboard comprising a personalized platform for translating text into a nucleic acid sequence; (b) translating a quantum of information into a nucleic acid message sequence using the modified keyboard of (a); and, (c) obtaining an at least one nucleic acid molecule, each molecule comprising: (i) the complete or a portion of the nucleic acid message sequence, and (ii) at least one contiguous stretch of randomized variable nucleic acid sequence flanking and/or inserted into the message sequence, thereby producing a nucleic acid molecule or a set of nucleic acid molecules containing the entire quantum of information.

Abstract translation: 在一些方面，本公开涉及关于核酸分子的信息的多路复用加密。 在一些方面，本公开涉及一种在至少一个核酸分子上传播的信息的安全通信的方法，所述方法包括（a）获得修改的键盘，其包括用于将文本翻译成核酸序列的个性化平台; （b）使用（a）的修改键盘将信息量翻译成核酸消息序列; 每个分子包含：（i）核酸消息序列的全部或部分，和（ii）至少一个连续的随机化可变核酸序列片段，其侧翼和/ /或插入到消息序列中，从而产生含有整个信息量的核酸分子或一组核酸分子。

公开(公告)号：WO2016069913A1

公开(公告)日：2016-05-06

申请号：PCT/US2015/058099

申请日：2015-10-29

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Inventor： LU, Timothy, Kuan-ta ,  CARR, Peter, A. ,  ZAKERI, Bijan

IPC: C12N15/87 ,  C12N15/74 ,  C12N15/00 ,  C12Q1/68

CPC classification number: C12N15/74 ,  C12N15/87 ,  C12Q1/68 ,  G06F19/24 ,  C12Q2521/507 ,  C12Q2563/185

Abstract: The disclosure relates to the use of steganographic methods to camouflage information encoded on nucleic acids. Specifically, the method comprising preparing a pool of recombinant nucleic acid constructs, wherein at least one of the constnjcts comprises the nucleic acid sequence to be camouflaged and wherein the pool is heterogeneous with respect to the orientation of the nucleic acid sequence to be camouflaged, and the information is camouflaged using genetic recombination.

Abstract translation: 本公开涉及使用隐写术方法伪装编码在核酸上的信息。 具体而言，所述方法包括制备重组核酸构建体的一个池，其中，所述constnjcts中的至少一个包括所述核酸序列被伪装，并且其中所述池是异构的相对于所述核酸序列的取向被伪装，和 这些信息是通过基因重组伪装的。