公开(公告)号：WO2023006565A1

公开(公告)日：2023-02-02

申请号：PCT/EP2022/070466

申请日：2022-07-21

Applicant: MEDICHEM, S.A.

Inventor： LOZANO VELILLA, José Andrés ,  GARCÍA ROVIRA, Montserrat ,  DURAN LÓPEZ, Ernesto

IPC: A61K9/00 ,  A61K47/02 ,  A61K47/18 ,  A61K31/4152

Abstract: This invention relates to a process for preparing a formulation of edaravone or a pharmaceutically acceptable salt thereof, concretely an aqueous injectable formulation, which contains low amounts of a certain impurity. This process comprises heat-sterilization of an aqueous formulation of edaravone or pharmaceutically acceptable salt thereof, which comprises bisulfite anions (HSO3-) and contains less than 1 ppm of oxygen.

公开(公告)号：WO2023275413A2

公开(公告)日：2023-01-05

申请号：PCT/EP2022/080147

申请日：2022-10-27

Applicant: MEDICHEM, S.A.

Inventor： FERNÁNDEZ GARROSA, Isabel ,  SUÑÉ POU, Marc ,  DURÁN LÓPEZ, Ernesto ,  LOZANO VELILLA, José Andrés ,  PUIG SERRANO, Jordi

IPC: A61K9/20 ,  A61K31/55 ,  A61P25/34 ,  A61K9/2009 ,  A61K9/2013

Abstract: The present invention relates to solid pharmaceutical formulations comprising varenicline or a pharmaceutical salt thereof, and at least a scavenger agent of nitrite anion.