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公开(公告)号：WO2023006565A1
公开(公告)日：2023-02-02
申请号：PCT/EP2022/070466
申请日：2022-07-21
Applicant: MEDICHEM, S.A.
IPC: A61K9/00 , A61K47/02 , A61K47/18 , A61K31/4152
Abstract: This invention relates to a process for preparing a formulation of edaravone or a pharmaceutically acceptable salt thereof, concretely an aqueous injectable formulation, which contains low amounts of a certain impurity. This process comprises heat-sterilization of an aqueous formulation of edaravone or pharmaceutically acceptable salt thereof, which comprises bisulfite anions (HSO3-) and contains less than 1 ppm of oxygen.
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Patent Agency Ranking
公开(公告)号：WO2019025521A1
公开(公告)日：2019-02-07
申请号：PCT/EP2018/070957
申请日：2018-08-02
Applicant: MEDICHEM, S.A.
Inventor： DURAN LÓPEZ, Ernesto , CARRERAS I VILAGRAN, Marçal
IPC: C07D471/08 , A61K31/4985 , A61P25/34
Abstract: The present invention relates to a novel polymorphic form of varenicline fumarate, to processes for their preparation,to pharmaceutical compositions comprising the same and to their therapeutic uses.
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3.发明申请PROCESS FOR THE ENANTIOSELECTIVE SYNTHESIS OF A TETRAHYDROBENZAZEPINE COMPOUND 审中-公开对四氢苯并吖庚因化合物进行有效选择性合成的方法
公开(公告)号：WO2014060575A2
公开(公告)日：2014-04-24
申请号：PCT/EP2013/071832
申请日：2013-10-18
Applicant: MEDICHEM S.A.
Inventor： DURAN LÓPEZ, Ernesto
IPC: C07D223/16
CPC classification number: C07D223/16
Abstract: This invention relates to an improved process for the enantioselective synthesis of ( R )-8-chloro-1-methyl-2,3,4,5-tetrahydro-1 H -3-benzazepine
Abstract translation: 本发明涉及用于对映体选择性合成（R）-8-氯-1-甲基-2,3,4,5-四氢-1 的 H ^ 的3-苯并氮杂
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公开(公告)号：WO2005108394A1
公开(公告)日：2005-11-17
申请号：PCT/EP2004/005098
申请日：2004-05-12
Applicant: MEDICHEM S.A. , DURAN LÓPEZ, Ernesto , TOJO SUÁREZ, Gabriel
Inventor： DURAN LÓPEZ, Ernesto , TOJO SUÁREZ, Gabriel
IPC: C07D417/12
CPC classification number: C07D417/12
Abstract: The present invention relates to a process for the preparation of 5-{4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl-2,4-thiazolidinedione of formula (I) (Rosiglitazone), which comprises the reaction of 5-{4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxyl]benzylidene-2,4-thiazolidinedione of formula (II), with a 1,4-dihydropyridine of general formula (III).
Abstract translation: 本发明涉及式（I）的5- {4- [2-（N-甲基-N-（2-吡啶基）氨基）乙氧基]苄基-2,4-噻唑烷二酮的制备方法（罗格列酮） 其包括式（II）的5- {4- [2-（N-甲基-N-（2-吡啶基）氨基）乙氧基]亚苄基-2,4-噻唑烷二酮与1,4-二氢吡啶 的通式（III）。
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公开(公告)号：WO2021170304A1
公开(公告)日：2021-09-02
申请号：PCT/EP2021/050520
申请日：2021-01-13
Applicant: MEDICHEM, S.A.
Inventor： PUIG SERRANO, Jordi , DURAN LÓPEZ, Ernesto , MARKALAIN BARTA, Jordi , FERREIRA DA COSTA, Joana Raquel
IPC: C08B37/16 , A61K31/724 , C08L5/16
Abstract: This invention relates to a process for preparing Sugammadex or its salts, preferably Sugammadex sodium, with a low content of organic solvents, preferably water-miscible organic solvents, more preferably ethanol, 2-propanol and/or acetone. The process comprises exposing Sugammadex or its salts, preferably Sugammadex sodium, to a medium with a high relative humidity.
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公开(公告)号：WO2019102009A1
公开(公告)日：2019-05-31
申请号：PCT/EP2018/082598
申请日：2018-11-26
Applicant: MEDICHEM, S.A.
Inventor： PUIG SERRANO, Jordi , BOSCH I LLADO, Jordi , NG CHOI, Iteng , DURAN LÓPEZ, Ernesto
IPC: C08B37/16
CPC classification number: C08B37/0012
Abstract: This invention relates to an improved process for the synthesis of Sugammadex or a salt thereof, to Sugammadex or a salt thereof having high purity as obtained by said process and to pharmaceutical compositions comprising said high purity Sugammadex or a salt thereof.
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