公开(公告)号：WO2014074470A1

公开(公告)日：2014-05-15

申请号：PCT/US2013/068385

申请日：2013-11-05

Applicant: MEDIMMUNE, LLC

Inventor： SELLMAN, Bret ,  TKACZYK, Christine ,  HAMILTON, Melissa ,  HUA, Lei

IPC: A61K39/085

CPC classification number: C07K16/1271 ,  A61K39/085 ,  A61K2039/505 ,  C07K2317/52 ,  C07K2317/565 ,  C07K2317/76

Abstract: The present invention provides for methods of preventing and/or treating S. aureusassociated bacteremia and sepsis, and methods for preventing and/or treating S. aureus associated pneumonia in immunocompromised patients using anti-S. aureus alpha-toxin (antiAT) antibodies. Also provided are methods of reducing S. aureus bacterial load in the bloodstream or heart of a mammalian subject comprising administering to the subject an effective amount of an isolated anti-S. aureus alpha toxin (anti-AT) antibody or antigen-binding fragment thereof. Methods of reducing S. aureus bacterial agglutination and/or thromboembolic lesion formation in a mammalian subject comprising administering to the subject an effective amount of an isolated anti-S. aureus alpha toxin (anti-AT) antibody or antigen-binding fragment thereof, are also provided. Also provided are methods of preventing or reducing the severity of S. aureus -associated pneumonia in an immunocompromised mammalian subject.

Abstract translation: 本发明提供了预防和/或治疗金黄色葡萄球菌相关菌血症和败血症的方法，以及在使用抗-S的免疫受损患者中预防和/或治疗金黄色葡萄球菌相关性肺炎的方法。 金黄色葡萄球菌α毒素（antiAT）抗体。 还提供了降低哺乳动物受试者的血液或心脏中的金黄色葡萄球菌细菌负荷的方法，包括向受试者施用有效量的分离的抗S。 金黄色葡萄球菌α毒素（抗AT）抗体或其抗原结合片段。 在哺乳动物受试者中降低金黄色葡萄球菌细菌凝集和/或血栓栓塞损伤形成的方法，包括向受试者施用有效量的分离的抗S。 还提供了金黄色葡萄球菌α毒素（抗AT）抗体或其抗原结合片段。 还提供了在免疫受损的哺乳动物受试者中预防或降低金黄色葡萄球菌相关性肺炎的严重性的方法。

公开(公告)号：WO2014074540A2

公开(公告)日：2014-05-15

申请号：PCT/US2013/068624

申请日：2013-11-06

Applicant: MEDIMMUNE, LLC

Inventor： SELLMAN, Bret ,  TKACZYK, Christine ,  CHOWDHURY, Partha, S. ,  HUA, Lei ,  PAVLIK, Peter ,  BUONPANE, Rebecca ,  CHANG, Chew-Shun

IPC: A61K39/40

CPC classification number: C07K16/1271 ,  A61K39/40 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/507 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/56938

Abstract: Antibodies and antigen binding fragments thereof directed against Staphylococcus aureus (S. aureus) surface determinant antigens and secreted toxins are disclosed. Methods of detecting, diagnosing and treating S. aureus using the antibodies and antigen binding fragments thereof are also provided.

Abstract translation: 公开了针对金黄色葡萄球菌（金黄色葡萄球菌）表面决定簇抗原和分泌毒素的抗体及其抗原结合片段。 还提供了使用抗体及其抗原结合片段检测，诊断和处理金黄色葡萄球菌的方法。

公开(公告)号：WO2012109285A3

公开(公告)日：2012-08-16

申请号：PCT/US2012/024201

申请日：2012-02-07

Applicant: MEDIMMUNE, LLC ,  SELLMAN, Bret ,  TKACZYK, Christine ,  HUA, Lei ,  CHOWDHURY, Partha ,  VARKEY, Reena ,  DAMSCHRODER, Melissa ,  PENG, Li ,  OGANESYAN, Vaheh ,  HILLIARD, Jamese, Johnson

Inventor： SELLMAN, Bret ,  TKACZYK, Christine ,  HUA, Lei ,  CHOWDHURY, Partha ,  VARKEY, Reena ,  DAMSCHRODER, Melissa ,  PENG, Li ,  OGANESYAN, Vaheh ,  HILLIARD, Jamese, Johnson

IPC: C12P21/08 ,  C07K16/00 ,  A61K39/40 ,  A61K39/085

Abstract: The disclosure provides compositions, methods of manufacture and methods of use of antibodies and fragments that bind Staphylococcus aureus alpha toxin. More specifically, the disclosure provides VH CDR and VL CDR region sequences of antibodies or antigen-binding fragments. Method of preventing, treating or managing a condition associated with Staphylococcus aureus infection using the antibodies are also disclosed.