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1.A NOVEL IL33 FORM, MUTATED FORMS OF IL33, ANTIBODIES, ASSAYS AND METHODS OF USING THE SAME 审中-公开
标题翻译: 新型IL33形式,IL33的突变形式,抗体,测定方法及其使用方法公开(公告)号:WO2016156440A1
公开(公告)日:2016-10-06
申请号:PCT/EP2016/056973
申请日:2016-03-30
申请人: MEDIMMUNE LIMITED
发明人: COHEN, Emma, S , LOWE, David, C , BUTLER, Robin , SCOTT, Ian, C , VOUSDEN, Katherine, A , STRAIN, Martin, D , CARMEN, Sara , ENGLAND, Elizabeth, H , KEMP, Benjamin, P , REES, David, G , OVERED-SAYER, Catherine, L , MUSTELIN, Tomas, M , SLEEMAN, Matthew , HOUSLAY, Kirsty
IPC分类号: C07K16/24 , A61K39/395 , A61K39/00 , A01K67/027 , C07K14/54 , C07K14/715
CPC分类号: C07K16/244 , A01K67/0278 , A01K2217/072 , A01K2227/105 , A01K2267/03 , A61K2039/505 , C07K14/54 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要: The present invention provides isolated IL-33 proteins, active fragments thereof and antibodies, antigen binding fragments thereof, against IL-33 proteins. Also provided are methods of modulating cytokine activity, e.g., for the purpose of treating immune and inflammatory disorders.
摘要翻译: 本发明提供了针对IL-33蛋白的分离的IL-33蛋白,其活性片段和抗体,其抗原结合片段。 还提供了调节细胞因子活性的方法,例如用于治疗免疫和炎性疾病的目的。