公开(公告)号：WO2012115771A2

公开(公告)日：2012-08-30

申请号：PCT/US2012/024203

申请日：2012-02-07

Applicant: MEDTRONIC, INC. ,  VAN ANTWERP, William ,  MANDA, Venkatesh, R. ,  WALSH, Andrew, J.L. ,  BURNES, John ,  EVANS, Daron ,  LIEU, Hsiao

Inventor： VAN ANTWERP, William ,  MANDA, Venkatesh, R. ,  WALSH, Andrew, J.L. ,  BURNES, John ,  EVANS, Daron ,  LIEU, Hsiao

IPC: A61K38/22 ,  A61K9/00

CPC classification number: A61K38/2242 ,  A61K9/0019

Abstract: Medical systems and methods for treating kidney disease alone, heart failure alone, kidney disease with concomitant heart failure, or cardiorenal syndrome are described. The systems and methods are based on delivery of a chimeric natriuretic peptide to a patient. Methods for increasing peptide levels include direct peptide delivery via either an external or implantable programmable pump.

Abstract translation: 描述单独治疗肾脏疾病，单独心力衰竭，伴有心力衰竭的肾脏疾病或心脏肾综合征的医疗系统和方法。 系统和方法基于将嵌合利钠肽递送给患者。 增加肽水平的方法包括通过外部或可植入的可编程泵的直接肽递送。

公开(公告)号：WO2017079712A1

公开(公告)日：2017-05-11

申请号：PCT/US2016/060757

申请日：2016-11-06

Applicant: MEDTRONIC, INC.

Inventor： ROETTGER, Amy ,  MANDA, Venkatesh, R. ,  BURNES, John ,  POINDEXTER, Rebecca ,  GERBER, Martin, T.

IPC: G06F19/00 ,  A61M1/34 ,  A61M1/36

CPC classification number: A61M1/3609 ,  A61B5/14546 ,  A61B5/4839 ,  A61B5/6866 ,  A61B5/7275 ,  A61M1/1696 ,  A61M1/341 ,  A61M1/3601 ,  A61M2205/3334 ,  A61M2230/005 ,  A61M2230/04 ,  A61M2230/20 ,  G06F19/00 ,  G06F19/3481 ,  G16H50/30

Abstract: Systems and methods are provided for determining an estimated risk of arrhythmia during or after dialysis based on changes in serum potassium concentration of a patient and an amount of fluid removed from the patient during dialysis. The systems and methods allow for a determination of a risk that arrhythmia will occur due to the changes in potassium and fluid volume of a patient during dialysis, and for optimizing a dialysis prescription in order to minimize the risk of arrhythmia.

公开(公告)号：WO2015066731A3

公开(公告)日：2015-05-07

申请号：PCT/US2014/065201

申请日：2014-11-12

Applicant: MEDTRONIC, INC. ,  SOYKAN, Orhan ,  HOBOT, Christopher, M. ,  GERBER, Martin, T. ,  MANDA, Venkatesh, R.

Inventor： SOYKAN, Orhan ,  HOBOT, Christopher, M. ,  GERBER, Martin, T. ,  MANDA, Venkatesh, R.

IPC: A61B5/20 ,  A61B5/02 ,  A61B5/0205 ,  A61M1/14

Abstract: A system and method for determining the amount of fluid to be removed from a dialysis patient is disclosed. The system utilizes sensors and a computer. The computer obtains the input parameters from the sensors, along with information added directly by the user, and performs a forward algorithm to determine a recommended change in patient fluid level. As fluid is removed, the effect of the removal on the parameters is detected by the sensors and re-transmitted back to the computer. The computer then performs a backward algorithm to refine the variables used in the forward algorithm and obtain more accurate results. The system and method provide for changing the amount of fluid removed from the patient based on the results of the algorithm and the data received from the sensors.

Abstract translation: 公开了一种用于确定从透析患者移除的流体量的系统和方法。 该系统使用传感器和计算机。 计算机从传感器获得输入参数以及用户直接添加的信息，并执行前向算法以确定患者液体水平的建议变化。 当流体被去除时，去除参数的效果被传感器检测到并重新传输回计算机。 计算机然后执行反向算法来改进前向算法中使用的变量并获得更准确的结果。 该系统和方法基于算法的结果和从传感器接收的数据提供改变从患者移除的流体量。

公开(公告)号：WO2012115772A2

公开(公告)日：2012-08-30

申请号：PCT/US2012/024207

申请日：2012-02-07

Applicant: MEDTRONIC, INC. ,  VAN ANTWERP, William ,  WALSH, Andrew, J. L. ,  MANDA, Venkatesh, R. ,  BURNES, John

Inventor： VAN ANTWERP, William ,  WALSH, Andrew, J. L. ,  MANDA, Venkatesh, R. ,  BURNES, John

IPC: A61K9/08 ,  A61K38/22

CPC classification number: A61K38/2242 ,  A61K9/0019 ,  A61K47/18 ,  A61M5/14228 ,  A61M5/14276

Abstract: Medical systems and methods for treating kidney disease alone, heart failure alone, chronic kidney disease with concomitant heart failure, or cardiorenal syndrome are described. The systems and methods are based on delivery of a natriuretic peptide such as Vessel Dilator to a subject. Methods for increasing and maintaining peptide levels at a certain concentration include direct peptide delivery via either an external or implantable programmable pump.

Abstract translation: 描述了单独治疗肾脏疾病，单独心力衰竭，伴有心力衰竭的慢性肾脏疾病或心脏肾综合征的医疗系统和方法。 系统和方法基于将利钠肽如血管释放器递送至受试者。 在一定浓度下增加和维持肽水平的方法包括通过外部或可植入的可编程泵的直接肽递送。