公开(公告)号：WO2022072491A1

公开(公告)日：2022-04-07

申请号：PCT/US2021/052645

申请日：2021-09-29

申请人： METACRINE, INC.

发明人： GOVEK, Steven P. ,  LAI, Andiliy G. ,  HUDSON, Andrew R. ,  SMITH, Nicholas D. ,  FASANYA, Karensa L.

IPC分类号： A61K31/34 ,  A61K31/39 ,  A61K31/40 ,  A61K31/537 ,  A61P29/00

摘要： Described herein are compounds that are HSD17B13 inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with HSD17B13 activity.

公开(公告)号：WO2022072512A1

公开(公告)日：2022-04-07

申请号：PCT/US2021/052674

申请日：2021-09-29

申请人： METACRINE, INC.

发明人： HUDSON, Andrew R. ,  GOVEK, Steven P. ,  NAGASAWA, Johnny Y. ,  BOTROUS, Iriny ,  SMITH, Nicholas D. ,  FASANYA, Karensa L.

IPC分类号： A61K31/34 ,  A61K31/39 ,  A61K31/40 ,  A61K31/537 ,  A61P29/00

摘要： Described herein are compounds that are HSD17B13 inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with HSD17B13 activity.

公开(公告)号：WO2022072517A1

公开(公告)日：2022-04-07

申请号：PCT/US2021/052679

申请日：2021-09-29

申请人： METACRINE, INC.

发明人： HUDSON, Andrew R. ,  GOVEK, Steven P. ,  NAGASAWA, Johnny Y. ,  BOTROUS, Iriny ,  SMITH, Nicholas D. ,  FASANYA, Karensa L.

IPC分类号： A61K31/34 ,  A61K31/39 ,  A61K31/40 ,  A61K31/537 ,  A61P29/00

摘要： Described herein are compounds that are HSD17B13 inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with HSD17B13 activity.