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公开(公告)号：WO2019241751A1
公开(公告)日：2019-12-19
申请号：PCT/US2019/037380
申请日：2019-06-14
申请人： METACRINE, INC.
IPC分类号： A61K31/137 , A61K31/381 , C07C217/62
摘要： Described herein are compounds that are semicarbazide-sensitive amine oxidase (SSAO) inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in treating or preventing a liver disease or condition.
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公开(公告)号：WO2022072512A1
公开(公告)日：2022-04-07
申请号：PCT/US2021/052674
申请日：2021-09-29
申请人： METACRINE, INC.
发明人： HUDSON, Andrew R. , GOVEK, Steven P. , NAGASAWA, Johnny Y. , BOTROUS, Iriny , SMITH, Nicholas D. , FASANYA, Karensa L.
IPC分类号： A61K31/34 , A61K31/39 , A61K31/40 , A61K31/537 , A61P29/00
摘要： Described herein are compounds that are HSD17B13 inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with HSD17B13 activity.
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公开(公告)号：WO2023043836A1
公开(公告)日：2023-03-23
申请号：PCT/US2022/043527
申请日：2022-09-14
申请人： METACRINE, INC.
发明人： NAGASAWA, Johnny Y. , BOTROUS, Iriny , LAI, Andiliy G. , HUDSON, Andrew R. , SMITH, Nicholas D. , GOVEK, Steven P.
IPC分类号： C07D401/10 , C07D403/04 , C07D403/10 , C07D413/04 , C07D413/10 , C07D471/04 , C07D487/04 , C07D401/14 , A61K31/4192 , A61K31/444 , A61K31/496 , A61K31/519 , A61K31/5377 , A61P1/16
摘要： Described herein are compounds that are HSD17B13 inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with HSD17B13 activity.
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公开(公告)号：WO2018170167A1
公开(公告)日：2018-09-20
申请号：PCT/US2018/022490
申请日：2018-03-14
申请人： METACRINE, INC.
IPC分类号： C07D217/22 , C07D471/04 , C07D401/04 , C07D403/04 , A61K31/47 , A61K31/4375 , A61K31/4545 , A61P1/16
摘要： Described herein are compounds that are farnesoid X receptor agonists, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with farnesoid X receptor activity.
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公开(公告)号：WO2022072517A1
公开(公告)日：2022-04-07
申请号：PCT/US2021/052679
申请日：2021-09-29
申请人： METACRINE, INC.
发明人： HUDSON, Andrew R. , GOVEK, Steven P. , NAGASAWA, Johnny Y. , BOTROUS, Iriny , SMITH, Nicholas D. , FASANYA, Karensa L.
IPC分类号： A61K31/34 , A61K31/39 , A61K31/40 , A61K31/537 , A61P29/00
摘要： Described herein are compounds that are HSD17B13 inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with HSD17B13 activity.
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公开(公告)号：WO2018170182A1
公开(公告)日：2018-09-20
申请号：PCT/US2018/022513
申请日：2018-03-14
申请人： METACRINE, INC.
发明人： SMITH, Nicholas D. , GOVEK, Steven P. , NAGASAWA, Johnny Y. , DOUGLAS, Karensa L. , LAI, Andiliy G.
IPC分类号： C07D417/12 , C07D403/12 , C07D401/12 , A61K31/4439 , A61K31/426 , A61K31/416 , A61P1/16
摘要： Described herein are compounds that are farnesoid X receptor agonists, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with farnesoid X receptor activity.
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公开(公告)号：WO2018170173A1
公开(公告)日：2018-09-20
申请号：PCT/US2018/022497
申请日：2018-03-14
申请人： METACRINE, INC.
IPC分类号： C07D213/36 , C07D241/20 , C07D261/08 , A61K31/44 , A61K31/496 , A61K31/42
摘要： Described herein are compounds that are farnesoid X receptor agonists, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with farnesoid X receptor activity.
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公开(公告)号：WO2018170166A1
公开(公告)日：2018-09-20
申请号：PCT/US2018/022489
申请日：2018-03-14
申请人： METACRINE, INC.
IPC分类号： C07D231/12 , C07D401/04 , C07D403/12 , A61K31/415 , A61K31/4439 , A61P1/16
摘要： Described herein are compounds that are farnesoid X receptor agonists, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with farnesoid X receptor activity.
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公开(公告)号：WO2018170165A1
公开(公告)日：2018-09-20
申请号：PCT/US2018/022488
申请日：2018-03-14
申请人： METACRINE, INC.
IPC分类号： C07D277/34 , C07D417/04 , C07D417/12 , A61K31/426 , A61K31/427 , A61K31/4439 , A61P1/16
摘要： Described herein are compounds that are farnesoid X receptor agonists, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with farnesoid X receptor activity.
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公开(公告)号：WO2017049173A1
公开(公告)日：2017-03-23
申请号：PCT/US2016/052270
申请日：2016-09-16
申请人： METACRINE, INC.
IPC分类号： C07D213/63 , C07D207/12 , A61K31/4418 , A61K31/4412 , A61K31/16
CPC分类号： A61K31/16 , A61K31/4412 , A61K31/4418 , C07C233/59 , C07C233/62 , C07C233/63 , C07C237/22 , C07C237/42 , C07C271/20 , C07C2601/04 , C07C2601/14 , C07D205/04 , C07D207/08 , C07D207/12 , C07D207/27 , C07D211/42 , C07D211/46 , C07D213/40 , C07D213/64 , C07D213/65 , C07D213/68 , C07D213/75 , C07D213/80 , C07D239/34 , C07D241/18 , C07D263/32 , C07D275/03 , C07D277/34 , C07D333/32
摘要： Described herein are compounds that are farnesoid X receptor agonists, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with farnesoid X receptor activity.
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