公开(公告)号：WO2013078312A1

公开(公告)日：2013-05-30

申请号：PCT/US2012/066258

申请日：2012-11-21

Applicant: MEZADATA MEDICAL IP HOLDING LLP

Inventor： FESKOV, Alexander ,  FESKOVA, Irina ,  ZHYLKOVA, Ievgeniia ,  ZHILKOV, Stanislav

IPC: C12N5/00

CPC classification number: A61B17/435 ,  A61D19/00 ,  A61D19/04 ,  A61K35/14 ,  A61K2035/124 ,  C12N5/0634 ,  C12N2501/31

Abstract: A method of in vitro fertilization wherein the embryo is implanted into the uterus of a female patient at least two, and preferably three to twelve months after the eggs are retrieved from the patient in order to reduce the effect of autoimmune rejection of the embryo by the patient's autoimmune system and increase the probability and success of pregnancy and wherein prior to embryo implantation, the endometrium in the uterus is prepared for embryo implantation by introducing peripheral blood mononuclear cells (PBMCs) into the uterus. The procedure is combined with cryopreservation techniques to preserve the oocytes or the IVF-produced embryos of the patient.

Abstract translation: 一种体外受精的方法，其中将胚胎植入女性患者的子宫中，在从患者中取出卵后至少两个，优选三至十二个月，以便通过所述方法减少胚胎的自身免疫排斥的影响 患者的自身免疫系统，并增加妊娠的概率和成功率，并且在胚胎植入之前，通过将外周血单核细胞（PBMC）引入子宫来准备子宫内膜的胚胎植入。 该方法与冷冻保存技术结合，以保存患者的卵母细胞或IVF产生的胚胎。