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公开(公告)号:WO2019229455A1
公开(公告)日:2019-12-05
申请号:PCT/GB2019/051496
申请日:2019-05-31
Applicant: MICROMASS UK LIMITED
Inventor: WILDGOOSE, Jason Lee , CARNEY, Peter , WAMSLEY, Ruth , JOHNSON, William , MCIVER, Paul , WALLIS, David , HARRISON, James
Abstract: A mass spectrometer comprising: an ion guide (301) comprising a first portion (1811) configured to guide ions along a first axial path, a second portion (1812) configured to guide ions along a second different axial path, and a transition portion (1813) configured to urge ions from the first axial path onto the second axial path; a downstream electrode (1713) arranged downstream of the ion guide (301); and a voltage supply arranged and configured to apply a potential difference between the ion guide (301) and the downstream electrode (1713) so as to accelerate ions to collide with gas and fragment.
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公开(公告)号:WO2019229467A1
公开(公告)日:2019-12-05
申请号:PCT/GB2019/051508
申请日:2019-05-31
Applicant: MICROMASS UK LIMITED
Inventor: CARNEY, Peter , HARRISON, James , HOUGH, Paul , WORTHINGTON, Kenneth R , MCIVER, Paul , SCHOFIELD, Alistar
Abstract: A mass spectrometer is disclosed comprising an ion optics device housing having one or more external electrical connectors (1719) provided thereon. An ion optics device (301) is arranged inside the ion optics device housing, the ion optics device (301) comprising one or more electrodes for manipulating ions, the one or more electrodes being electrically connected to the one or more external electrical connectors (1719) provided on the ion optics device housing. A voltage supply housing (1717) is provided having one or more external electrical connectors provided thereon. One or more voltage supplies are arranged inside the voltage supply housing (1717), the one or more voltage supplies being in electrical communication with the one or more external electrical connectors provided on the voltage supply housing. The one or more external electrical connectors provided on the voltage supply housing are directly physically and electrically connected to the one or more external electrical connectors (1719) provided on the ion optics device housing.
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公开(公告)号:WO2019229459A1
公开(公告)日:2019-12-05
申请号:PCT/GB2019/051500
申请日:2019-05-31
Applicant: MICROMASS UK LIMITED
Inventor: CARNEY, Peter , CHUMMAR, Soji
Abstract: An assembly for a mass spectrometer, comprising a housing (106) and a Time of Flight analyser (110), wherein the housing (106) is configured to enclose at least the Time of Flight analyser (110), and the Time of Flight analyser comprises a pusher assembly (120) and a flight tube (160), wherein the Time of Flight mass analyser (110) is cantilevered from the housing.
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公开(公告)号:WO2019229460A1
公开(公告)日:2019-12-05
申请号:PCT/GB2019/051501
申请日:2019-05-31
Applicant: MICROMASS UK LIMITED
Inventor: CARNEY, Peter , MURRAY, Haydn , WILDGOOSE, Jason
Abstract: Disclosed herein is a bench-top time of flight mass spectrometer (100). In embodiments, there is provided a solvent bottle mounting assembly configured so that a user can press a solvent bottle (201) onto the solvent bottle mounting assembly in order to mount the solvent bottle to the mass spectrometer. Other embodiments relate to a vacuum arrangement comprising first and second vacuum chambers with respective first and second vacuum pumps wherein a backing line (1401) for the second vacuum pump is connected to the first vacuum chamber such that the second vacuum pump is backed to the first vacuum chamber. Also disclosed in a method of manufacturing a lens plate or electrode wherein a substrate is chemically etched to reduce a sharp cusp (1803) to provide a smoother edge profile (1804).
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公开(公告)号:WO2019229457A1
公开(公告)日:2019-12-05
申请号:PCT/GB2019/051498
申请日:2019-05-31
Applicant: MICROMASS UK LIMITED
Inventor: CARNEY, Peter , CHUMMAR, Soji , WILDGOOSE, Jason Lee , WAMSLEY, Ruth
Abstract: A Time of Flight analyser comprising a flight tube (160) and a reflectron (170), wherein the reflectron comprises a stack of electrodes (172) that are compressed against the flight tube such that they remain parallel to each other under compression.
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公开(公告)号:WO2019229453A1
公开(公告)日:2019-12-05
申请号:PCT/GB2019/051494
申请日:2019-05-31
Applicant: MICROMASS UK LIMITED
Inventor: WAMSLEY, Ruth , WILSON, Michael , CARNEY, Peter , THRELFALL, Richard , HENDERSON, Matthew , MCIVER, Paul
IPC: H01J49/00
Abstract: A mass spectrometer includes a control system arranged to assess an operational state of the mass spectrometer. When a fault is detected, the control system assigns the fault to one of a plurality of categories, including a first category of faults which may be attempted to be rectified automatically by the mass spectrometer, a second category of faults which may be attempted to be rectified by the user, and a third category of faults which may only be attempted to be rectified by a service engineer. When a fault is assigned to the first category of faults, the control system initiates an attempt to automatically rectify the fault. When a fault is assigned to the second category of faults, the control system causes information relating to the fault to be displayed to the user, including data indicative of the fault and data one or more steps to be taken by the user to attempt to rectify the fault (2000). When a fault is assigned to the third category of faults, the control system causes information relating to the fault to be displayed to the user including data indicative of the fault, and an indication that the user should call a service engineer.
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公开(公告)号:WO2019229465A1
公开(公告)日:2019-12-05
申请号:PCT/GB2019/051506
申请日:2019-05-31
Applicant: MICROMASS UK LIMITED
Inventor: MCIVER, Paul , WAMSLEY, Ruth , CARNEY, Peter , CHUMMAR, Soji , MURRAY, Haydn
Abstract: A mass spectrometer comprising: a vacuum chamber housing an electronic component therein; a voltage supply module for supplying a voltage to said electronic component; a pressure sensor for determining the pressure in the vacuum chamber; and a control module configured to cut power to the voltage supply module when the pressure sensor determines that the pressure in the vacuum chamber is at or above a predetermined threshold pressure, such that the voltage supply module is incapable of supplying a voltage to the electronic component.
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公开(公告)号:WO2019229462A1
公开(公告)日:2019-12-05
申请号:PCT/GB2019/051503
申请日:2019-05-31
Applicant: MICROMASS UK LIMITED
Inventor: MARSH, Cedric , CARNEY, Peter , WILDGOOSE, Jason Lee , WALLIS, David , MCIVER, Paul , CHUMMAR, Soji , ANTONIADES, George Andreas , MISTRY, Dipesh
Abstract: A mass spectrometer comprising: a vacuum housing comprising a first vacuum chamber having a first gas exhaust port; a gas pump (1700) having a first gas inlet port connected to the first gas exhaust port (H1) by a first gas conduit for evacuating the first vacuum chamber; and a first apertured cover (2010) arranged over the first gas exhaust port (H1) or first gas inlet port, or in the first gas conduit therebetween.
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公开(公告)号:WO2019229458A1
公开(公告)日:2019-12-05
申请号:PCT/GB2019/051499
申请日:2019-05-31
Applicant: MICROMASS UK LIMITED
Inventor: WAMSLEY, Ruth , WILSON, Michael , TRIVETT, Ian , CARNEY, Peter , MURRAY, Haydn , MCIVER, Paul
IPC: H01J49/06
Abstract: A mass spectrometer comprising: a vacuum chamber; and an ion inlet assembly for transmitting analyte ions into the vacuum chamber; wherein the spectrometer is configured to operate in a cooling mode in which it selectively controls one or more gas flow to the ion inlet assembly for actively cooling the ion inlet assembly.
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