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公开(公告)号：WO2023091750A1
公开(公告)日：2023-05-25
申请号：PCT/US2022/050567
申请日：2022-11-21
申请人： CORNELL UNIVERSITY
发明人： CIRA, Nathaniel James , TAN, Shenghao , SHIRI, Samira , QAZI, Mohsin Jahan , ALBO, Jon , CHEN, Arnold
摘要： This technology provides a liquid dispensing system with a liquid loading device that can be used to load small volumes of liquid by sliding over or under a surface-patterned substrate, or, alternately, moving the surface-patterned substrate over or under the liquid loading device. The surface-patterned substrate may be a substrate with patterned geometry or wettability. The liquid loading device spatially confines liquid against the surface-patterned substrate and delivers it to intended areas on the surface-patterned substrate. The liquid loading device accomplishes this by maintaining liquid in spatially confined sections, and moving relative to the substrate, by, for example, sliding over it to deposit liquid on the surface-patterned substrate. The liquid loading device utilizes geometry and/or wettability to achieve liquid confinement and delivery to intended areas on the surface-patterned substrate.
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3.发明申请
公开(公告)号：WO2023287924A1
公开(公告)日：2023-01-19
申请号：PCT/US2022/037021
申请日：2022-07-13
申请人： PROTIFI, LLC
发明人： WILSON, John, Paul
摘要： A method of quantifying target molecules comprising the steps of: binding target molecules to a surface, wherein the target molecules are presented for a quantification assay; cleaning the target molecules of contaminating reagents, wherein the target molecules remain bound to the surface; directly quantifying the target molecules, wherein the target molecules remain bound to the surface, wherein direct quantification of the target molecules is performed by measurement of intrinsic fluorescence of the target molecules.
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公开(公告)号：WO2022261936A1
公开(公告)日：2022-12-22
申请号：PCT/CN2021/100894
申请日：2021-06-18
发明人： WU, Changhong , LI, Zhongqiu , YU, Xufeng , CHEN, Jue
摘要： A cassette (1000), including: a frame (100) defining an accommodating chamber (101); an intermediate member (210) coupled to the frame (100) and movably arranged in the accommodating chamber (101), the intermediate member (210) having a through hole (218) in the middle; a cover (220) rotatably connected to the intermediate member (210) and configured to be closed to cover the through hole (218); a base (300) connected to the intermediate member (210) and configured to receive the tissue sample (400); and a retaining member (230) connected to the cover (220) and configured to pass through the through hole (218) to retain the tissue sample (400) in the base (300), the retaining member (230) having a three-dimensional structure made of a two-dimensional porous material.
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公开(公告)号：WO2022256736A1
公开(公告)日：2022-12-08
申请号：PCT/US2022/032355
申请日：2022-06-06
摘要： The disclosure provides example devices and methods for virus and bacterium detection and identification. The example device includes (a) a housing having an air inlet and an air outlet, (b) a substrate disposed within the housing, where the at least one substrate has a through-slot, where the substrate has a plurality of wells, (c) an air-handling and precipitation chamber, a reagent and reaction chamber, and a detection chamber arranged in series and each coupled to the top surface of the substrate, (d) a first actuator coupled to the substrate and configured to rotate the substrate, (e) a second actuator coupled to and configured to rotate the air-handling and precipitation chamber, the reagent and reaction chamber, and the detection chamber, and (f) at least one processor electrically coupled to the air-handling and precipitation chamber, the reagent and reaction chamber, the detection chamber, the first actuator, and the second actuator.
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公开(公告)号：WO2022215817A1
公开(公告)日：2022-10-13
申请号：PCT/KR2021/013847
申请日：2021-10-08
申请人： 인제대학교 산학협력단
摘要： 본 발명은 액적 크기 제어가 가능한 능동형 액적 생성장치, 이를 이용한 액적 크기 제어방법 및 액적 생성 자가진단 장치에 관한 것으로서, 더욱 상세하게는 정전용량 임피던스 기법으로 액적 크기를 빠르고 정확하게 측정하여 피드백 제어방식으로 액적을 원하는 크기로 조절할 수 있어 액적 개수를 가변할 수 있으면서도 액적 생성에 대한 자가진단이 가능한 효과를 갖는다.
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公开(公告)号：WO2022213077A1
公开(公告)日：2022-10-06
申请号：PCT/US2022/071426
申请日：2022-03-29
发明人： ELMS, Phillip J. M. , NG, Preston Lock , CHENG, Jonathan , VER HEUL, Nathan J. , YEE, Jason King Mckenzie , CHIRRA DINAKAR, Hariharasudhan , TOBIAS, Renee Lynn , SACKMANN, Eric K. , ZINK, Wesley Arthur , NEIRA-QUINTERO, Hector D.
摘要： Methods for identifying a cell population secreting a biomolecule with desirable attributes are disclosed. The desirable attributes can include, for example, quantity and quality (e.g., minimal aggregation and/or desired configuration). Cell populations identified by the disclosed methods are more likely to successfully scale during production. The methods can include assessing multiple domains/binding sites of a complex biomolecule and/or the formation of aggregates by the biomolecules. Methods of assessing a secretion level for biomolecules having a wide range of molecular weights and method for enhancing loading of cells into chambers of a microfluidic device. The labelling of viable cells and/or cells actively expressing a biomolecule of interest, for example, can permit selection and subsequent analysis of the cells most likely to successfully expand and express the biomolecule of interest, thereby reducing effort, risk, and cost associated with the screening of cells and increase the probability of identifying cell lines that are optimal producers of biomolecules of interest.
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公开(公告)号：WO2022212643A2
公开(公告)日：2022-10-06
申请号：PCT/US2022/022742
申请日：2022-03-31
申请人： QCDX LLC
IPC分类号： G01N1/00 , G01N21/00 , G01N33/48 , G01N33/483 , G01N1/30 , C12Q1/68 , G01N33/533
摘要： The present invention provides methods and systems for analyzing a biological sample. The methods of the present invention can utilize a labeling moiety and a cleavage moiety. The labeling moiety can comprise a binding moiety that is coupled to a detectable tag via a polynucleotide linker. The cleavage moiety can form a complex with the polynucleotide linker. In some cases, after formation of the complex, the cleavage moiety can effect cleavage of the polynucleotide linker, to release the detectable tag from the binding moiety. The release of the detectable tag can allow one or more additional imaging of the biological sample with a different labeling moiety that comprises a different binding moiety but the same labeling moiety.
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公开(公告)号：WO2022204598A1
公开(公告)日：2022-09-29
申请号：PCT/US2022/022200
申请日：2022-03-28
发明人： JÄGER, Ralf , PURPURA, Martin , WELLS, Shawn , LIAO, Kylin
摘要： Disclosed herein are compositions and methods for attenuating stress-induced mental fatigue in subject in need thereof by administering to the subject a composition comprising from about 2 mg to about 800 mg of paraxanthine. In certain embodiments, paraxanthine is present in the composition in amount from about 20 mg to about 600 mg. In further embodiments, paraxanthine is present in the composition in amount from about 50 mg to about 400 mg. According to certain embodiments, fatigue attenuated by the instantly disclosed method is a result of physical stress on the subject. Physical stresses that may result in mental fatigue include, but are not limited to, periods of intense exercise.
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公开(公告)号：WO2022196781A1
公开(公告)日：2022-09-22
申请号：PCT/JP2022/012450
申请日：2022-03-17
申请人： キヤノン株式会社
摘要： 無駄な液体の消費を抑制することができる液体注入方法、液体注入装置および液体カートリッジを提供する。そのために、液体を吐出する液体吐出ヘッドと、前記液体吐出ヘッドと接続され前記液体吐出ヘッドに液体を供給可能な流路と、前記流路と接続され前記流路より広く設けられた開口部と、を備えた液体カートリッジに液体注入器から液体を注入する液体注入方法であって、液体を前記流路内に直接注入する。
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