公开(公告)号：WO2014055543A2

公开(公告)日：2014-04-10

申请号：PCT/US2013/062902

申请日：2013-10-01

Applicant: MILLENNIUM PHARMACEUTICALS, INC.

Inventor： BLAKEMORE, Stephen, J. ,  LI, Bin ,  SHIN, Hyunjin ,  TREPICCHIO, William, L.

IPC: C12Q1/68

CPC classification number: C12Q1/6886 ,  A61K31/519 ,  C12Q1/6834 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/16 ,  G06F17/18 ,  G06F19/12 ,  C12Q2521/301 ,  C12Q2525/131 ,  C12Q2565/518

Abstract: Disclosed herein are markers associated with sensitivity to treatment with therapeutic agents. Methods to identify markers for predicting outcome to treatment with a therapeutic agent are disclosed as well as methods to predict outcome of treatment using markers. Compositions and methods are provided to predict response to NAE inhibition or EGFR inhibition treatment.

Abstract translation: 本文公开了与治疗剂治疗敏感性有关的标志物。 公开了鉴定用于预测治疗剂治疗结果的标记物的方法以及预测使用标记物治疗结果的方法。 提供组合物和方法来预测对NAE抑制或EGFR抑制治疗的反应。

公开(公告)号：WO2013063481A1

公开(公告)日：2013-05-02

申请号：PCT/US2012/062240

申请日：2012-10-26

Applicant: MILLENNIUM PHARMACEUTICALS, INC.

Inventor： BLAKEMORE, Stephen, J. ,  LI, Bin ,  MULLIGAN, George, J. ,  SCHU, Matthew, C. ,  SMITH, Peter, G.

IPC: C12Q1/68 ,  G01N33/50

CPC classification number: A61K31/519 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/156 ,  G01N33/57484 ,  G01N2800/52 ,  G01N2800/60 ,  G06F19/00 ,  G06F19/328

Abstract: Disclosed herein are markers whose mutational status is associated with sensitivity to treatment with NAE inhibitors. Mutational status is determined by measurement of characteristics of markers associated with the marker genes. Compositions and methods are provided to assess markers of marker genes to predict response to NAE inhibition treatment.

Abstract translation: 本文公开了其突变状态与用NAE抑制剂治疗的敏感性相关的标志物。 通过测量与标记基因相关的标记的特征来确定突变状态。 提供组合物和方法来评估标记基因的标记以预测对NAE抑制治疗的反应。