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    MEANS AND METHODS FOR THE ENRICHMENT OF NUCLEIC ACIDS
    1.
    发明申请
    MEANS AND METHODS FOR THE ENRICHMENT OF NUCLEIC ACIDS 审中-公开
    用于增殖核酸的方法和方法

    公开(公告)号：WO2016184987A1

    公开(公告)日：2016-11-24

    申请号：PCT/EP2016/061333

    申请日：2016-05-19

    Applicant: YAYA DIAGNOSTICS GMBH

    Inventor： DYCK, Joachim ,  LENK, Jens ,  SAUERMANN, Stefan ,  PÖHLMANN, Tobias

    IPC: A61B10/00 ,  C12Q1/68

    CPC classification number: C12Q1/6806 ,  A61B10/0045 ,  C12Q2527/146 ,  C12Q2565/518 ,  C12Q2565/519 ,  C12Q2565/531

    Abstract: The present invention relates to means for and methods of collecting, enriching, and analyzing nucleic acids of interest of interest, e.g. those that are associated with the development of sepsis. These means may be used in vivo or in vitro using obtained nucleic acids of interest, e.g. for liquid biopsies. The invention can, inter alia, be used in the detection and enrichment as well as analysis of nucleic acids of interests such as those derived from pathogens or from individuals that may contain such pathogens.

    Abstract translation: 本发明涉及收集，丰富和分析感兴趣的核酸的方法和方法，例如， 那些与败血症发展有关的那些。 这些方法可以在体内或体外使用获得的感兴趣的核酸，例如， 用于液体活检。 本发明尤其可以用于检测和富集以及分析感兴趣的核酸，例如衍生自病原体或可能含有这种病原体的个体的核酸。

    METHODS FOR AMPLIFYING NUCLEIC ACIDS ON SUBSTRATES
    4.
    发明申请
    METHODS FOR AMPLIFYING NUCLEIC ACIDS ON SUBSTRATES 审中-公开
    在底物上放大核酸的方法

    公开(公告)号：WO2016003809A1

    公开(公告)日：2016-01-07

    申请号：PCT/US2015/038028

    申请日：2015-06-26

    Applicant: GENERAL ELECTRIC COMPANY

    Inventor： NELSON, John Richard ,  DUTHIE, Robert Scott ,  PULEO, Christopher Michael ,  SPOONER, Patrick McCoy

    IPC: C12Q1/70

    CPC classification number: C12Q1/6848 ,  C12Q2531/119 ,  C12Q2531/125 ,  C12Q2565/518

    Abstract: A method is provided herein, the method includes: applying a sample comprising target nucleic acids to a sample application zone of a substrate; applying an aqueous buffer to the sample application zone of the substrate to washes away one or more inhibitors present on the sample application zone; and applying an isothermal nucleic acid amplification reaction mixture to the sample application zone to amplify the target nucleic acid to form a nucleic acid amplification product. The target nucleic acid having a first molecular weight is substantially immobilized at the sample application zone and wherein the amplification product having a second molecular weight.

    Abstract translation: 本文提供了一种方法，所述方法包括：将包含靶核酸的样品施加到底物的样品施用区域; 将水性缓冲液施加到基材的样品施加区域以洗涤存在于样品施加区上的一种或多种抑制剂; 以及将等温核酸扩增反应混合物应用于样品施用区域以扩增靶核酸以形成核酸扩增产物。 具有第一分子量的靶核酸基本上固定在样品施用区，其中扩增产物具有第二分子量。

    METHODS OF ELONGATING DNA
    6.
    发明申请
    METHODS OF ELONGATING DNA 审中-公开
    开发DNA的方法

    公开(公告)号：WO2014164716A1

    公开(公告)日：2014-10-09

    申请号：PCT/US2014/023295

    申请日：2014-03-11

    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE

    Inventor： WU, Chao-ting

    IPC: C12Q1/68

    CPC classification number: C12Q1/6834 ,  C12P19/34 ,  C12Q1/6841 ,  C12Q2521/537 ,  C12Q2523/307 ,  C12Q2543/10 ,  C12Q2565/518

    Abstract: The present invention relates to methods of elongating chromosomes. Embodiments of the present disclosure are directed to methods of elongating DNA by immobilizing or attaching the DNA to a substrate. According to one aspect, naturally occurring DNA includes a nucleic acid and one or more factors bound thereto, and may be referred to herein as "starting DNA

    Abstract translation: 本发明涉及延长染色体的方法。 本公开的实施方案涉及通过将DNA固定或附着到底物来延长DNA的方法。 根据一个方面，天然存在的DNA包括核酸和与其结合的一个或多个因子，并且在本文中可以称为“起始DNA

    SEQUENCING METHODS
    10.
    发明申请
    SEQUENCING METHODS 审中-公开
    序列方法

    公开(公告)号：WO2013019361A1

    公开(公告)日：2013-02-07

    申请号：PCT/US2012/045783

    申请日：2012-07-06

    Applicant: LIFE TECHNOLOGIES CORPORATION ,  MYERS, Jason ,  CHEN, Zhoutao ,  DRESSMAN, Devin ,  NIKIFOROV, Theo

    Inventor： MYERS, Jason ,  CHEN, Zhoutao ,  DRESSMAN, Devin ,  NIKIFOROV, Theo

    IPC: C12Q1/68

    CPC classification number: C12Q1/6874 ,  C12Q1/6806 ,  C12Q1/6869 ,  C12Q2521/307 ,  C12Q2521/325 ,  C12Q2525/125 ,  C12Q2535/119 ,  C12Q2565/518

    Abstract: Provided herein are compositions, systems, methods and kits useful for obtaining sequence information from a nucleic acid molecule. In some embodiments, the compositions, systems, methods and kits are useful for sequencing of natural or modified nucleic acids. In some embodiments, the compositions, systems, methods and kits relate to bi-directional sequencing of nucleic acids. In some embodiments, the compositions, systems, methods and kits relate to sequencing of nucleic acids linked to a solid support. In some embodiments, the methods useful for obtaining sequence information from a nucleic acid molecule include label-free or ion-based sequencing methods.

    Abstract translation: 本文提供了可用于从核酸分子获得序列信息的组合物，系统，方法和试剂盒。 在一些实施方案中，组合物，系统，方法和试剂盒可用于测序天然或修饰的核酸。 在一些实施方案中，组合物，系统，方法和试剂盒涉及核酸的双向测序。 在一些实施方案中，组合物，系统，方法和试剂盒涉及与固体支持物连接的核酸的测序。 在一些实施方案中，可用于从核酸分子获得序列信息的方法包括无标记或基于离子的测序方法。

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