公开(公告)号：WO2014149067A1

公开(公告)日：2014-09-25

申请号：PCT/US2013/043786

申请日：2013-05-31

Applicant: MOMENTA PHARMACEUTICALS, INC.

Inventor： ROBBLEE, John ,  HE, Xiaomei ,  YIN, Yan ,  LIN, Yin, Yin ,  COLLINS, Brian ,  MURPHY, Jennifer ,  KAUNDINYA, Ganesh, V.

IPC: C07K19/00

CPC classification number: C07K14/70521 ,  C07K2319/30

Abstract: The present disclosure provides, in part, methods for evaluating, identifying, and/or producing (e.g., manufacturing) a CTLA4-Fc fusion protein, e.g., abatacept. In some instances, methods herein allow highly resolved evaluation of abatacept useful for, inter alia, manufacturing abatacept, characterizing abatacept, identifying and/or confirming abatacept, monitoring the structure of abatacept, comparing abatacept preparations made over time or made under different conditions, and/or controlling the structure of abatacept.

Abstract translation: 本公开部分地提供用于评估，鉴定和/或产生（例如制造）CTLA4-Fc融合蛋白（例如abatacept）的方法。 在某些情况下，这里的方法允许高度分辨的对abatacept的评估，特别是制造abatacept，表征abatacept，鉴定和/或确认abatacept，监测abatacept的结构，比较随时间推移或在不同条件下制备的abatacept制剂， /或控制abatacept的结构。