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公开(公告)号：WO2020117184A1
公开(公告)日：2020-06-11
申请号：PCT/US2018/063529
申请日：2018-12-02
申请人： BINHAI INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE OF ZHEJIANG UNIVERSITY , TIANJIN YUNFU MEDICAL TECHNOLOGY CO., LTD. , MPROBE INC.
发明人： LING, Bruce Xuefeng , CHEN, Linmin , HAO, Shiying
IPC分类号： G01N33/68
摘要： Preeclampsia markers, preeclampsia (PE) marker panels, and methods for obtaining a preeclampsia marker level representation for a sample are provided. These composition and methods find use in a number of applications, including, for example, diagnosing preeclampsia, prognosing preeclampsia, monitoring a subject with preeclampsia, and determining a treatment for preeclampsia. In addition, systems, devices, and kits thereof that find use in practicing the subject methods are provided.
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公开(公告)号：WO2018174876A1
公开(公告)日：2018-09-27
申请号：PCT/US2017/023680
申请日：2017-03-22
申请人： MPROBE INC.
发明人： LING, Bruce, Xuefeng , CHEN, Limin , HAO, Shiying
CPC分类号： G01N33/6848 , A61B5/00 , G01N33/48 , G01N33/6893 , G01N2570/00 , G01N2800/368
摘要： Preeclampsia markers, preeclampsia marker panels, and methods for obtaining a preeclampsia marker level representation for a sample are provided, based upon small molecule metabolic profiling. These composition and methods find use in a number of applications, including, for example, diagnosing preeclampsia, prognosing preeclampsia, monitoring a subject with preeclampsia, and determining a treatment for preeclampsia, in addition, systems, devices, and kits thereof that find use in practicing the subject methods are provided.
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3.发明申请
公开(公告)号：WO2018174891A1
公开(公告)日：2018-09-27
申请号：PCT/US2017/023863
申请日：2017-03-23
申请人： MPROBE INC.
发明人： LING, Bruce Xuefeng , CHEN, Limin , HAO, Shiying
CPC分类号： G01N33/6848 , G01N33/48 , G01N2458/15 , G01N2570/00 , G16H50/20
摘要： A mixture of internal standards for the quantitative analysis of targeted metabolites using flow injection chromatography interfaced with electrospray tandem mass spectrometry has been developed and validated. This mixture contains both non-isotope- and isotope-labeled chemicals to be used as internal standards for the correction of extraction recovery, normalization of ionization efficiency, and quantification of endogenous metabolites of interest. Compared to the conventional internal standard mixture where only isotope-labeled chemicals are included, this mixture allows the quantitative targeted metabolomics to be implemented in a more cost-effective and economically favorable manner without compromising the quality of the analysis in terms of accuracy and precision.
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4.发明申请
公开(公告)号：WO2018174860A1
公开(公告)日：2018-09-27
申请号：PCT/US2017/023474
申请日：2017-03-21
申请人： MPROBE INC.
发明人： LING, Xuefeng, Bruce , CHEN, Limin , HAO, Shiying
CPC分类号： G01N33/57423 , C12Q1/6886 , C12Q2600/158 , G01N2800/60
摘要： Lung adenocarcinoma markers, lung adenocarcinoma marker panels, and methods for obtaining a lung adenocarcinoma marker level representation for a sample are provided, based upon RNAseq expression profiling. These composition and methods find use in a number of applications, including, for example, diagnosing lung adenocarcinoma, prognosing lung adenocarcinoma, monitoring a subject with lung adenocarcinoma, and determining a treatment for lung adenocarcinoma. In addition, systems, devices, and kits thereof that find use in practicing the subject methods are provided.
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5.发明申请
公开(公告)号：WO2018174863A1
公开(公告)日：2018-09-27
申请号：PCT/US2017/023478
申请日：2017-03-21
申请人： MPROBE INC.
发明人： LING, Bruce, Xuefeng , CHEN, Limin , HAO, Shiying
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , G01N33/57419
摘要： Colon cancer markers, colon cancer marker panels, and methods for obtaining a colon cancer marker level representation for a sample are provided, based upon RNAseq expression profiling. These composition and methods find use in a number of applications, including, for example, diagnosing colon cancer, prognosing colon cancer, monitoring a subject with colon cancer, and determining a treatment for colon cancer. In addition, systems, devices, and kits thereof that find use in practicing the subject methods are provided.
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6.发明申请
公开(公告)号：WO2018174862A1
公开(公告)日：2018-09-27
申请号：PCT/US2017/023476
申请日：2017-03-21
申请人： MPROBE INC.
发明人： LING, Bruce, Xuefeng , CHEN, Limin , HAO, Shiying
CPC分类号： C12Q1/6886 , C07H21/00 , C12Q1/68 , C12Q2600/112 , C12Q2600/158
摘要： Bladder cancer markers, bladder cancer marker panels, and methods for obtaining a bladder cancer marker level representation for a sample are provided, based upon RNAseq expression profiling. These composition and methods find use in a number of applications, including, for example, diagnosing bladder cancer, prognosing bladder cancer, monitoring a subject with bladder cancer, and determining a treatment for bladder cancer. In addition, systems, devices, and kits thereof that find use in practicing the subject methods are provided.
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7.发明申请
公开(公告)号：WO2018174861A1
公开(公告)日：2018-09-27
申请号：PCT/US2017/023475
申请日：2017-03-21
申请人： MPROBE INC.
发明人： LING, Bruce, Xuefeng , CHEN, Limin , HAO, Shiying
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/158
摘要： Breast cancer markers, breast cancer marker panels, and methods for obtaining a breast cancer marker level representation for a sample are provided, based upon RNAseq expression profiling. These composition and methods find use in a number of applications, including, for example, diagnosing breast cancer, prognosing breast cancer, monitoring a subject with breast cancer, and determining a treatment for breast cancer. In addition, systems, devices, and kits thereof that find use in practicing the subject methods are provided.
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8.发明申请
公开(公告)号：WO2018140049A1
公开(公告)日：2018-08-02
申请号：PCT/US2017/015554
申请日：2017-01-30
申请人： MPROBE INC.
发明人： LING, Bruce, Xuefeng , CHEN, Limin , HAO, Shiying
CPC分类号： G01N33/57449 , C12Q1/6886 , C12Q2600/158
摘要： Ovarian cancer markers, ovarian cancer marker panels, and methods for obtaining an ovarian cancer marker level representation for a sample are provided, based upon RNAseq expression profiling. These composition and methods find use in a number of applications, including, for example, diagnosing ovarian cancer, prognosing ovarian cancer, monitoring a subject with ovarian cancer, and determining a treatment for ovarian cancer, in addition, systems, devices, and kits thereof that find use in practicing the subject methods are provided.
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9.发明申请
公开(公告)号：WO2022186821A1
公开(公告)日：2022-09-09
申请号：PCT/US2021/020417
申请日：2021-03-02
申请人： MPROBE INC., , THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR , LING, Bruce, Xuefeng , CHEN, Limin , COHEN, Harvey, J. , HAO, Shiying , MCELHINNEY, Doff, B. , SYLVESTER, Karl, G. , TIAN, Lu , WONG, Ronald, J. , SHAW, Gary, M. , STEVENSON, David, K.
发明人： LING, Bruce, Xuefeng , CHEN, Limin , COHEN, Harvey, J. , HAO, Shiying , MCELHINNEY, Doff, B. , SYLVESTER, Karl, G. , TIAN, Lu , WONG, Ronald, J. , SHAW, Gary, M. , STEVENSON, David, K.
摘要： Preeclampsia markers, preeclampsia marker panels, and methods for obtaining a preeclampsia marker level representation for a sample are provided. These composition and methods find use in a number of applications, including, for example, diagnosing preeclampsia, prognosing preeclampsia, monitoring a subject with preeclampsia, and determining a treatment for preeclampsia. In addition, systems, devices, and kits thereof that find use in practicing the subject methods are provided.
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公开(公告)号：WO2020112149A1
公开(公告)日：2020-06-04
申请号：PCT/US2018/063517
申请日：2018-12-01
申请人： BINHAI INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE OF ZHEJIANG UNIVERSITY , TIANJIN YUNJIAN MEDICAL TECHNOLOGY CO., LTD. , MPROBE INC.
发明人： LING, Bruce Xuefeng , CHEN, Linmin , HAO, Shiying
摘要： Acute myocardial infarction (AMI) biomarkers, AMI biomarker panels, and methods obtaining AMI biomarker level representation for a sample are provided. These composition and methods find use in a number of applications, including, for example, stratifying AMI, diagnosing AMI, prognosing AMI, monitoring a subject with AMI, and determining a treatment for AMI. In addition, systems, devices, and kits thereof that find use in practicing the subject methods are provided.
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