公开(公告)号：WO2022186782A1

公开(公告)日：2022-09-09

申请号：PCT/SG2022/050117

申请日：2022-03-07

Applicant: NANYANG TECHNOLOGICAL UNIVERSITY

Inventor： LIU, Chuan Fa ,  XIA, Yiyin ,  TAM, James P.

IPC: C12P21/04 ,  C07K7/64 ,  C07K14/00 ,  A61K38/12 ,  A61K38/16

Abstract: The present invention relates to methods that employ enzymes having Asn-specific cyclase activity as a means for generating cyclic (poly)peptides from (poly)peptides that comprise a ligation motif comprising a Nγ-hydroxy-L-asparagine or Nγ-amino-L-asparagine residue. Further encompassed are the resulting cyclic (poly)peptides and the corresponding uses.