公开(公告)号：WO2017175238A1

公开(公告)日：2017-10-12

申请号：PCT/IN2017/050074

申请日：2017-02-22

Applicant: NEON LABORATORIES LIMITED

Inventor： DALVI, Mahesh Bhagoji ,  KENNY, Rajesh Shashikant ,  PATIL, Ajit Aappa ,  PALKAR, Tushar Tanaji

IPC: C07C269/00 ,  C07C271/00

Abstract: : The invention discloses a novel process for highly chemoselective reactions of substituted anilines without any detectable reaction at aromatic amino group. The invention also relates to a novel process for preparation of neostigmine methylsulphate via chemoselective reaction of 3-amionphenol and aryl dimethylcarbamates.

Abstract translation: 本发明公开了一种在芳香族氨基上没有任何可检测反应的取代苯胺的高度化学选择性反应的新方法。 本发明还涉及通过3-氨基苯酚和芳基二甲基氨基甲酸酯的化学选择性反应制备新斯的明甲基硫酸酯的新方法。

公开(公告)号：WO2020148777A1

公开(公告)日：2020-07-23

申请号：PCT/IN2020/050036

申请日：2020-01-11

Applicant: NEON LABORATORIES LIMITED

Inventor： DALVI, Mahesh Bhagoji ,  KENNY, Rajesh Shashikant ,  PALKAR, Tushar Tanaji

IPC: A61K31/40

Abstract: The present invention discloses an improved process for preparation of highly pure cyclopentyl mandelic acid derivative of formula (I), an intermediate of glycopyrrolate, without using hazardous chemicals.

公开(公告)号：WO2018193463A1

公开(公告)日：2018-10-25

申请号：PCT/IN2018/050153

申请日：2018-03-16

Applicant: NEON LABORATORIES LIMITED

Inventor： DALVI, Mahesh Bhagoji ,  KENNY, Rajesh Shashikant ,  PATIL, Ajit Aappa ,  PALKAR, Tushar Tanaji

IPC: C07D453/02

CPC classification number: C07D215/20

Abstract: The present invention discloses an improved process for preparation of substantially pure pentamethylene bis(1-(3,4-dimethoxybenzyl)-3,4-dihydro-6,7- dimethoxy-1H-isoquinoline-2-propionate), a compound of formula I and its acid addition salts in good yields. Pentamethylene bis(1-(3,4-dimethoxybenzyl)-3,4- dihydro-6,7-dimethoxy-1H-isoquinoline-2-propionate) or its acid addition salts is the key intermediate for the synthesis of a non-depolarizing neuromuscular-blocking drugs. The process can also be used for the synthesis of various tetrahydroisoquinoline derivatives.