公开(公告)号：WO2016078944A1

公开(公告)日：2016-05-26

申请号：PCT/EP2015/076010

申请日：2015-11-09

Applicant: NESTEC S.A.

Inventor： VALSESIA, Armand ,  HAGER, Jorg

IPC: C12Q1/68

CPC classification number: C12Q1/6883 ,  C12Q2600/118 ,  C12Q2600/156 ,  C12Q2600/172

Abstract: A method for assessing the predisposition of a subject to weight loss attainable by applyingone or more dietary interventions to a subject and/or the predisposition of a subject to maintenance of weight loss following one or more dietary interventions which method comprises determining the nucleotide of the subject at one or more polymorphic positions selected from: (i) position 101 of SEQ ID NO:1 (rs953211) (ii) position 101 of SEQ ID NO:2 (rs1509290) (iii) position 101 of SEQ ID NO:3 (rs1509289) and/or detecting one or more biomarkers genetically linked to said polymorphic positions.

Abstract translation: 一种评估受试者易感性的方法，所述方法包括测定受试者的核苷酸，通过在受试者身上施用一种或多种膳食干预措施，和/或受试者倾向于维持一种或多种饮食干预后的体重减轻， （i）SEQ ID NO：1的位置101（rs953211）（ii）SEQ ID NO：2的位置101（rs1509290）（iii）SEQ ID NO：3的位置101（rs1509289）的一个或多个多态性位置 ）和/或检测与所述多态性位置遗传连锁的一种或多种生物标志物。

公开(公告)号：WO2019101490A1

公开(公告)日：2019-05-31

申请号：PCT/EP2018/079923

申请日：2018-11-01

Applicant: NESTEC S.A.

Inventor： GHELDOF, Nele ,  VALSESIA, Armand ,  HAGER, Jorg

IPC: A61K31/573 ,  C12N15/113 ,  A61P3/04

CPC classification number: A61K31/573 ,  A61P3/04 ,  C12N15/1135

Abstract: An agent capable of decreasing the activity of ALK for use in supporting weight maintenance and/or treating or preventing obesity.

公开(公告)号：WO2016020119A1

公开(公告)日：2016-02-11

申请号：PCT/EP2015/064670

申请日：2015-06-29

Applicant: NESTEC S.A.

Inventor： HAGER, Jorg ,  IRINCHEEVA, Irina ,  VALSESIA, Armand ,  SARIS, Wim ,  ASTRUP, Arne

IPC: G01N33/86 ,  G01N33/66 ,  G01N33/573

CPC classification number: G01N33/66 ,  G01N33/6893 ,  G01N2333/52 ,  G01N2333/62 ,  G01N2333/765 ,  G01N2333/96447 ,  G01N2800/044 ,  G06F19/00 ,  G06F19/3475

Abstract: A method for predicting the degree of weight loss attainable by applying one or more dietary interventions to a subject, said method comprising determining the level of one or more biomarkers in one or more samples obtained from the subject, wherein the biomarkers are selected from fructosamine and factor VII.

Abstract translation: 一种用于预测通过对受试者施用一种或多种膳食干预可获得的体重减轻程度的方法，所述方法包括确定从受试者获得的一种或多种样品中的一种或多种生物标志物的水平，其中所述生物标志物选自果糖胺和 因子VII。

公开(公告)号：WO2018099933A1

公开(公告)日：2018-06-07

申请号：PCT/EP2017/080737

申请日：2017-11-29

Applicant: NESTEC S.A.

Inventor： CARAYOL, Jérôme ,  VALSESIA, Armand ,  HAGER, Jorg

IPC: C12N15/113 ,  A61K31/00 ,  A61K31/7088

Abstract: An agent capable of decreasing the activity of FAM46A for use in supporting weight maintenance and/or treating or preventing obesity.

公开(公告)号：WO2018178247A1

公开(公告)日：2018-10-04

申请号：PCT/EP2018/058101

申请日：2018-03-29

Applicant: NESTEC S.A.

Inventor： VALSESIA, Armand ,  GHELDOF, Nele ,  HAGER, Jorg

IPC: C12N15/113 ,  A61K31/7088

Abstract: An agent capable of decreasing the activity of ANK1 for use in (i) reducing fat accumulation and/or (ii) preserving or increasing fat free mass.

公开(公告)号：WO2017207513A1

公开(公告)日：2017-12-07

申请号：PCT/EP2017/062942

申请日：2017-05-30

Applicant: NESTEC S.A.

Inventor： VALSESIA, Armand ,  HAGER, Jorg ,  CARAYOL, Jérôme

IPC: C12Q1/68

Abstract: The present invention relates to a method for predicting the degree of weight loss attainable by applying one or more dietary interventions to a subject and/or the degree of maintenance of weight loss following one or more dietary interventions; which method comprises determining the level of microRNA-486 (miR-486) in one or more samples obtained from the subject; and/or determining the nucleotide of the subject at one or more polymorphic positions genetically linked to miR-486.

Abstract translation: 本发明涉及预测通过对受试者施用一种或多种饮食干预和/或在一次或多次饮食干预后维持体重减轻的程度可达到的体重减轻程度的方法; 该方法包括确定从受试者获得的一个或多个样品中的微小RNA-486（miR-486）的水平; 和/或测定受试者在与miR-486遗传连锁的一个或多个多态性位置处的核苷酸。

公开(公告)号：WO2017174716A1

公开(公告)日：2017-10-12

申请号：PCT/EP2017/058245

申请日：2017-04-06

Applicant: NESTEC S.A.

Inventor： CARAYOL, Jérôme ,  HAGER, Jorg ,  VALSESIA, Armand

IPC: C12Q1/68 ,  A61K31/015 ,  A61K31/05 ,  A61K31/19

Abstract: An agent capable of increasing the activity of branched-chain alpha-keto acid dehydrogenase (BCKDH) for use in increasing leptin levels. The invention also relates to the use of such agents for supporting satiety and for supporting weight maintenance and/or treating or preventing obesity.

Abstract translation: 能够增加用于增加瘦素水平的支链α-酮酸脱氢酶（BCKDH）活性的试剂。 本发明还涉及这些药物用于支持饱腹感和支持体重维持和/或治疗或预防肥胖症的用途。