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公开(公告)号：WO2019043103A1
公开(公告)日：2019-03-07
申请号：PCT/EP2018/073357
申请日：2018-08-30
发明人： DE MAN, Adrianus Petrus Antonius , UITDEHAAG, Joost Cornelis Marinus , STERRENBURG, Jan Gerard , DE WIT, Joeri Johannes Petrus , VAN CAUTER, Freek , SEEGERS, Nicole Wilhelmina Cornelia , VAN DOORNMALEN, Antonius Maria , BUIJSMAN, Rogier Christian , ZAMAN, Guido Jenny Rudolf
IPC分类号： C07D405/04 , C07D409/04 , C07D409/14 , C07D417/04 , A61K31/4178 , A61P35/00 , A61P25/00 , A61P31/00 , A61P37/00
CPC分类号： C07D409/04 , A61P25/00 , A61P31/00 , A61P35/00 , A61P37/00 , C07D405/04 , C07D409/14 , C07D417/04
摘要： The invention relates to a compound of Formula (I) : Formula (I), or pharmaceutically acceptable enantiomers, or salts thereof. The present invention also relates to the use of compounds of Formula (I) as selective inhibitors of indoleamine 2,3-dioxygenase. The invention also relates to the use of the compounds of Formula (I) for the treatment or prevention of diseases cancer, infections, central nervous system disease or disorder, and immune-related disorders, either as a single agent or in combination with other therapies.
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公开(公告)号：WO2015155042A1
公开(公告)日：2015-10-15
申请号：PCT/EP2015/056839
申请日：2015-03-30
发明人： DE MAN, Adrianus Petrus Antonius , BUIJSMAN, Rogier Christian , STERRENBURG, Jan Gerard , UITDEHAAG, Joost Cornelis Marinus , DE WIT, Joeri Johannes Petrus , ZAMAN, Guido Jenny Rudolf
IPC分类号： C07D471/22 , A61K31/519 , A61P35/00
CPC分类号： C07D471/14 , C07D471/22
摘要： The invention relates to a compound of Formula (I) wherein, R 1 and R 2 independently are selected from the group consisting of optionally substituted (6-10C)aryl and (1-5C)heteroaryl groups. The compounds can be used in pharmaceutical compositions, in particular in the treatment of cancer.
摘要翻译： 本发明涉及式（I）化合物，其中R1和R2独立地选自任选取代的（6-10C）芳基和（1-5C）杂芳基。 该化合物可用于药物组合物，特别是用于治疗癌症。
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公开(公告)号：WO2018011227A1
公开(公告)日：2018-01-18
申请号：PCT/EP2017/067447
申请日：2017-07-11
发明人： DE MAN, Adrianus Petrus Antonius , UITDEHAAG, Joost Cornelis Marinus , STERRENBURG, Jan Gerard , DE WIT, Joeri Johannes Petrus , SEEGERS, Nicole Wilhelmina Cornelia , VAN DOORNMALEN, Antonius Maria , BUIJSMAN, Rogier Christian , ZAMAN, Guido Jenny Rudolf
IPC分类号： C07D401/12 , C07D405/12 , C07D453/02 , C07D471/04 , C07D209/18 , A61K31/404 , A61P35/00
摘要： The invention relates to a compound of Formula I : Formula I, or pharmaceutically acceptable enantiomers, or salts thereof. The present invention also relates to the use of compounds of Formula (I) as selective inhibitors of tryptophan 2,3-dioxygenase. The invention also relates to the use of the compounds of Formula (I) for the treatment or prevention of cancer and central nervous system disease or disorder, either as a single agent or in combination with other therapies.
摘要翻译： 本发明涉及式I的化合物或其药学上可接受的对映体或其盐。 本发明还涉及式（I）化合物作为色氨酸2,3-双加氧酶的选择性抑制剂的用途。 本发明还涉及式（I）化合物用于治疗或预防癌症和中枢神经系统疾病或病症的用途，作为单一药物或与其他疗法组合。
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公开(公告)号：WO2017153459A1
公开(公告)日：2017-09-14
申请号：PCT/EP2017/055419
申请日：2017-03-08
发明人： DE MAN, Adrianus Petrus Antonius , UITDEHAAG, Joost Cornelis Marinus , STERRENBURG, Jan Gerard , DE WIT, Joeri Johannes Petrus , SEEGERS, Nicole Wilhelmina Cornelia , VAN DOORNMALEN, Antonius Maria , BUIJSMAN, Rogier Christian , ZAMAN, Guido Jenny Rudolf
IPC分类号： C07D233/32 , C07D403/06 , C07D405/06 , A61K31/4166 , A61K31/4178 , A61K31/4995 , A61P37/00 , A61P35/00 , A61P25/00 , A61P31/00
摘要： The invention relates to a compound of Formula (I), or pharmaceutically acceptable enantiomers, or salts thereof. The present invention also relates to the use of compounds of Formula (I) as selective inhibitors of indoleamine 2,3-dioxygenase. The invention also relates to the use of the compounds of Formula (I) for the treatment or prevention of diseases cancer, infections, central nervous system disease or disorder, and immune-related disorders, either as a single agent or in combination with other therapies.
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的对映体或其盐。 本发明还涉及式（I）化合物作为吲哚胺2,3-双加氧酶的选择性抑制剂的用途。 本发明还涉及式（I）化合物用作治疗或预防疾病癌症，感染，中枢神经系统疾病或病症以及免疫相关病症的用途，作为单一药物或与其他疗法组合
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