公开(公告)号：WO2019043103A1

公开(公告)日：2019-03-07

申请号：PCT/EP2018/073357

申请日：2018-08-30

申请人： NETHERLANDS TRANSLATIONAL RESEARCH CENTER B.V.

发明人： DE MAN, Adrianus Petrus Antonius ,  UITDEHAAG, Joost Cornelis Marinus ,  STERRENBURG, Jan Gerard ,  DE WIT, Joeri Johannes Petrus ,  VAN CAUTER, Freek ,  SEEGERS, Nicole Wilhelmina Cornelia ,  VAN DOORNMALEN, Antonius Maria ,  BUIJSMAN, Rogier Christian ,  ZAMAN, Guido Jenny Rudolf

IPC分类号： C07D405/04 ,  C07D409/04 ,  C07D409/14 ,  C07D417/04 ,  A61K31/4178 ,  A61P35/00 ,  A61P25/00 ,  A61P31/00 ,  A61P37/00

CPC分类号： C07D409/04 ,  A61P25/00 ,  A61P31/00 ,  A61P35/00 ,  A61P37/00 ,  C07D405/04 ,  C07D409/14 ,  C07D417/04

摘要： The invention relates to a compound of Formula (I) : Formula (I), or pharmaceutically acceptable enantiomers, or salts thereof. The present invention also relates to the use of compounds of Formula (I) as selective inhibitors of indoleamine 2,3-dioxygenase. The invention also relates to the use of the compounds of Formula (I) for the treatment or prevention of diseases cancer, infections, central nervous system disease or disorder, and immune-related disorders, either as a single agent or in combination with other therapies.

公开(公告)号：WO2018011227A1

公开(公告)日：2018-01-18

申请号：PCT/EP2017/067447

申请日：2017-07-11

申请人： NETHERLANDS TRANSLATIONAL RESEARCH CENTER B.V.

发明人： DE MAN, Adrianus Petrus Antonius ,  UITDEHAAG, Joost Cornelis Marinus ,  STERRENBURG, Jan Gerard ,  DE WIT, Joeri Johannes Petrus ,  SEEGERS, Nicole Wilhelmina Cornelia ,  VAN DOORNMALEN, Antonius Maria ,  BUIJSMAN, Rogier Christian ,  ZAMAN, Guido Jenny Rudolf

IPC分类号： C07D401/12 ,  C07D405/12 ,  C07D453/02 ,  C07D471/04 ,  C07D209/18 ,  A61K31/404 ,  A61P35/00

摘要： The invention relates to a compound of Formula I : Formula I, or pharmaceutically acceptable enantiomers, or salts thereof. The present invention also relates to the use of compounds of Formula (I) as selective inhibitors of tryptophan 2,3-dioxygenase. The invention also relates to the use of the compounds of Formula (I) for the treatment or prevention of cancer and central nervous system disease or disorder, either as a single agent or in combination with other therapies.

摘要翻译： 本发明涉及式I的化合物或其药学上可接受的对映体或其盐。 本发明还涉及式（I）化合物作为色氨酸2,3-双加氧酶的选择性抑制剂的用途。 本发明还涉及式（I）化合物用于治疗或预防癌症和中枢神经系统疾病或病症的用途，作为单一药物或与其他疗法组合。

公开(公告)号：WO2017153459A1

公开(公告)日：2017-09-14

申请号：PCT/EP2017/055419

申请日：2017-03-08

申请人： NETHERLANDS TRANSLATIONAL RESEARCH CENTER B.V.

发明人： DE MAN, Adrianus Petrus Antonius ,  UITDEHAAG, Joost Cornelis Marinus ,  STERRENBURG, Jan Gerard ,  DE WIT, Joeri Johannes Petrus ,  SEEGERS, Nicole Wilhelmina Cornelia ,  VAN DOORNMALEN, Antonius Maria ,  BUIJSMAN, Rogier Christian ,  ZAMAN, Guido Jenny Rudolf

IPC分类号： C07D233/32 ,  C07D403/06 ,  C07D405/06 ,  A61K31/4166 ,  A61K31/4178 ,  A61K31/4995 ,  A61P37/00 ,  A61P35/00 ,  A61P25/00 ,  A61P31/00

摘要： The invention relates to a compound of Formula (I), or pharmaceutically acceptable enantiomers, or salts thereof. The present invention also relates to the use of compounds of Formula (I) as selective inhibitors of indoleamine 2,3-dioxygenase. The invention also relates to the use of the compounds of Formula (I) for the treatment or prevention of diseases cancer, infections, central nervous system disease or disorder, and immune-related disorders, either as a single agent or in combination with other therapies.

摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的对映体或其盐。 本发明还涉及式（I）化合物作为吲哚胺2,3-双加氧酶的选择性抑制剂的用途。 本发明还涉及式（I）化合物用作治疗或预防疾病癌症，感染，中枢神经系统疾病或病症以及免疫相关病症的用途，作为单一药物或与其他疗法组合