公开(公告)号：WO2021081147A1

公开(公告)日：2021-04-29

申请号：PCT/US2020/056750

申请日：2020-10-22

申请人： NEUROCYCLE THERAPEUTICS, INC.

发明人： TOCZKO, Matthew ,  HUBBS, Jed ,  NING, YuXi ,  LI, Zheng Jane ,  HE, Yunliang ,  LIU, Xianglei

IPC分类号： C07D471/04 ,  C07D487/04 ,  C07D519/00

摘要： Described herein are polymorphs comprising 2',6-difluoro-5'-[3-(1-hydroxy-1-methylethyl)-imidazo[1,2-b][1,2,4]triazin-7-yl]biphenyl-2-carbonitrile (TPA023B) or salts thereof. In one aspect, disclosed herein is a crystalline polymorphic salt or co-crystal of TPA023B with phosphoric acid. In another aspect, disclosed herein is a crystalline polymorphic salt or co-crystal of TPA023B with sulfuric acid. Also described herein are methods of making and using the same.

公开(公告)号：WO2021081357A1

公开(公告)日：2021-04-29

申请号：PCT/US2020/057104

申请日：2020-10-23

申请人： NEUROCYCLE THERAPEUTICS, INC.

发明人： HUBBS, Jed ,  TOCZKO, Matthew

IPC分类号： A61K31/4196 ,  C07D249/08 ,  C07D249/16 ,  A61P25/08

摘要： Disclosed herein are GABAA receptor modulators and compositions comprising GABAA receptor modulators for treatment of epileptic conditions. Also disclosed herein are methods of treating epileptic conditions in a subject by administering a GABAA receptor modulators or composition as described herein.

公开(公告)号：WO2019204446A1

公开(公告)日：2019-10-24

申请号：PCT/US2019/027880

申请日：2019-04-17

申请人： NEUROCYCLE THERAPEUTICS, INC.

发明人： TOCZKO, Matthew ,  HUBBS, Jed

IPC分类号： C07D471/04 ,  C07D487/04 ,  C07D519/00

摘要： Described herein are polymorphs comprising 2',6-difluoro-5'-[3-(1-hydroxy-1-methylethyl)-imidazo[1,2-b][1,2,4]triazin-7-yl]biphenyl-2-carbonitrile (TPA023B) or salts thereof. In one aspect, disclosed herein is a crystalline polymorphic salt or co-crystal of TPA023B with phosphoric acid. Also described herein are methods of making and using the same.

公开(公告)号：WO2020191047A1

公开(公告)日：2020-09-24

申请号：PCT/US2020/023355

申请日：2020-03-18

申请人： NEUROCYCLE THERAPEUTICS, INC.

发明人： TOCZKO, Matthew ,  HUBBS, Jed

IPC分类号： A61K31/551 ,  C07D471/04 ,  C07D487/04

摘要： Disclosed herein are GABA A receptor modulators and compositions comprising GABA A receptor modulators for treatment of pain and associated conditions such as fibromyalgia. Also disclosed herein are methods of treating pain and associated conditions in a subject by administering a GABA A receptor modulators or composition as described herein.

公开(公告)号：WO2019226820A1

公开(公告)日：2019-11-28

申请号：PCT/US2019/033598

申请日：2019-05-22

申请人： NEUROCYCLE THERAPEUTICS, INC.

发明人： TOCZKO, Matthew ,  HUBBS, Jed

IPC分类号： A61K31/437 ,  A61K31/5025 ,  A61P17/04 ,  C07D237/28 ,  C07D471/04

摘要： Disclosed herein are GABAA positive allosteric modulators for the treatment of pruritic conditions and dermatitis. Also disclosed herein are formulations comprising the GABAA positive allosteric modulators.