专利检索 ap:("NEUROCYCLE THERAPEUTICS, INC.") AND inv:"LI, Zheng Jane" 第 1 页

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发明申请
GABAA POSITIVE ALLOSTERIC MODULATOR COMPOUNDS, METHODS OF MAKING, AND USES THEREOF 审中-公开

公开(公告)号：WO2021081147A1

公开(公告)日：2021-04-29

申请号：PCT/US2020/056750

申请日：2020-10-22

申请人： NEUROCYCLE THERAPEUTICS, INC.

发明人： TOCZKO, Matthew , HUBBS, Jed , NING, YuXi , LI, Zheng Jane , HE, Yunliang , LIU, Xianglei

IPC分类号： C07D471/04 , C07D487/04 , C07D519/00

摘要： Described herein are polymorphs comprising 2',6-difluoro-5'-[3-(1-hydroxy-1-methylethyl)-imidazo[1,2-b][1,2,4]triazin-7-yl]biphenyl-2-carbonitrile (TPA023B) or salts thereof. In one aspect, disclosed herein is a crystalline polymorphic salt or co-crystal of TPA023B with phosphoric acid. In another aspect, disclosed herein is a crystalline polymorphic salt or co-crystal of TPA023B with sulfuric acid. Also described herein are methods of making and using the same.