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1.发明申请HEAT-INDUCED GRAFTING OF NONWOVENS FOR HIGH CAPACITY ION EXCHANGE SEPARATION 审中-公开用于高容量离子交换分离的非织物热诱导接枝
公开(公告)号：WO2018015871A1
公开(公告)日：2018-01-25
申请号：PCT/IB2017/054312
申请日：2017-07-17
摘要： The invention provides methods for preparing a polymer-grafted and functionalized nonwoven membrane adapted for use in separation processes. The invention further provides so-formed membranes as well as improved separation methods utilizing the membranes. The polymer-grafted and functionalized nonwoven membranes are particularly formed utilizing thermal grafting. In particular, an acrylate or methacrylate polymer can be grafted onto a nonwoven web comprising a plurality of polymeric fibers to form a plurality of polymer segments covalently attached to the polymeric fibers. Thermal grafting particularly can comprise using a thermal initiator and exposing the nonwoven web to heat to initiate polymerization of the acrylate or methacrylate monomer. The grafted polymeric fibers can be functionalized to attach at least one functional group adapted for binding to a target molecule to the polymer segments of the grafted polymeric fibers.
摘要翻译： 本发明提供了用于制备适用于分离过程的聚合物接枝和官能化非织造膜的方法。 本发明进一步提供了如此形成的膜以及使用该膜的改进的分离方法。 聚合物接枝和官能化非织造膜特别利用热接枝形成。 特别地，可以将丙烯酸酯或甲基丙烯酸酯聚合物接枝到包含多个聚合物纤维的非织造纤维网上以形成多个共价连接至聚合物纤维的聚合物链段。 热接枝尤其可以包括使用热引发剂并将非织造纤维网暴露于热以引发丙烯酸酯或甲基丙烯酸酯单体的聚合。 接枝的聚合物纤维可以被官能化以将至少一个适于与目标分子结合的官能团连接到接枝的聚合物纤维的聚合物链段上。
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2.发明申请GRAFTED ISLANDS-IN-THE-SEA NONWOVEN FOR HIGH CAPACITY ION EXCHANGE BIOSEPARATION 审中-公开海拔高的岛屿 - 海上无海外交流生物多样性
公开(公告)号：WO2017019874A1
公开(公告)日：2017-02-02
申请号：PCT/US2016/044505
申请日：2016-07-28
CPC分类号： B01D71/48 , B01D67/003 , B01D69/10 , D04H1/435 , D04H1/4382 , D04H3/011 , D04H3/016
摘要： The invention provides polymer-grafted and functionalized nonwoven membranes adapted for use in bioseparation processes, the membranes including a nonwoven web of polyester fibers having an average fiber diameter of less than about 1.5 microns, each of the plurality of polyester fibers having grafted thereon a plurality of polymer segments constructed of a methacrylate polymer, each polymer segment carrying a functional group adapted for binding to a target molecule. The invention also provides a method of bioseparation comprising passing a solution comprising the target molecule, such as a protein, through the nonwoven membrane of the invention such that at least a portion of the target molecule in the solution binds to the nonwoven membrane. A method for preparing a polymer-grafted and functionalized nonwoven membrane adapted for use in bioseparation processes is also provided.
摘要翻译： 本发明提供了适用于生物分离方法的聚合物接枝和官能化非织造膜，该膜包括平均纤维直径小于约1.5微米的聚酯纤维的非织造纤维网，多个聚酯纤维中的每一个在其上接枝多个 的由甲基丙烯酸酯聚合物构成的聚合物链段，每个聚合物链段带有适于与靶分子结合的官能团。 本发明还提供了一种生物分离方法，包括使包含靶分子例如蛋白质的溶液通过本发明的非织造膜，使得溶液中的目标分子的至少一部分与非织造膜结合。 还提供了一种制备适用于生物分离方法的聚合物接枝和官能化非织造膜的方法。
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公开(公告)号：WO2014093196A1
公开(公告)日：2014-06-19
申请号：PCT/US2013/073805
申请日：2013-12-09
CPC分类号： C07K1/047
摘要： A method of making a peptide of Formula (I) : is described, along with compounds and methods of sequencing. A method of making a peptide of Formula (I) is described, along with compounds and methods of sequencing. Further provided is a method for the synthesis of a solid-phase combinatorial library of compounds functionalized with natural and non natural groups displayed on a peptide scaffold, along with compounds useful for carrying out such methods.
摘要翻译： 描述制备式（I）的肽的方法，以及化合物和测序方法。 描述了制备式（I）的肽的方法以及化合物和测序方法。 还提供了一种用于合成在肽支架上显示的天然和非天然组合官能化的化合物的固相组合文库的方法，以及可用于实施这些方法的化合物。
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