公开(公告)号：WO2020257261A1

公开(公告)日：2020-12-24

申请号：PCT/US2020/038103

申请日：2020-06-17

Applicant: NORTHWESTERN UNIVERSITY

Inventor： SCHILTZ, Gary, E ,  JAIN, Atul ,  HAN, Huiying ,  ABDULKADIR, Sarki, A.

IPC: C07D231/14 ,  C07D231/18 ,  C07D233/58 ,  C07D401/04 ,  C07D401/10 ,  C07D403/04 ,  C07D403/12 ,  C07D405/04 ,  C07D405/10 ,  A61K31/415 ,  A61K31/4152 ,  A61K31/4164 ,  A61K31/4192 ,  A61P35/00

Abstract: Disclosed are substituted heterocycle compounds including substituted pyrazoles, substituted pyrimidines, and substitute tri azoles. The substituted heterocycles disclosed herein are shown to be useful in inhibiting c-MYC and may be utilized as therapeutics for treating cancer and cell proliferative disorders.

公开(公告)号：WO2020046382A1

公开(公告)日：2020-03-05

申请号：PCT/US2018/049175

申请日：2018-08-31

Applicant: NORTHWESTERN UNIVERSITY

Inventor： SCHILTZ, Gary, E. ,  MISHRA, Rama, K. ,  HAN, Huiying ,  ABDULKADIR, Sarki, A. ,  IZQUIERDO-FERRER, Javier ,  JAIN, Atul, D.

IPC: C07D231/10 ,  C07D239/24 ,  C07D249/06 ,  C07D403/04 ,  A61K31/415 ,  A61K31/4192 ,  A61K31/505 ,  A61P35/00

Abstract: Disclosed are substituted heterocycle compounds including substituted pyrazoles, substituted pyrimidines, and substitute triazoles. The substituted heterocycles disclosed herein are shown to be useful in inhibiting c-MYC and may be utilized as therapeutics for treating cancer and cell proliferative disorders.