公开(公告)号：WO2022043547A1

公开(公告)日：2022-03-03

申请号：PCT/EP2021/073869

申请日：2021-08-30

Applicant: NOVOZYMES A/S

Inventor： LENHARD, Rolf, Thomas ,  FRIIS, Esben, Peter ,  PEDERSEN, Poul, Erik ,  ANDERSEN, Rasmus, Lund

IPC: C12N9/16

Abstract: The present invention relates to protease variants, polynucleotides encoding said variants, nucleic acid constructs and expression vectors comprising said polynucleotides, host cells expressing said variants, methods of obtaining the variants, detergent compositions comprising said variants, and use of said variants or said detergent compositions.

公开(公告)号：WO2018134386A1

公开(公告)日：2018-07-26

申请号：PCT/EP2018/051382

申请日：2018-01-22

Applicant: NOVOZYMES A/S

Inventor： NIELSEN, Allan, Kent ,  KOEBMANN, Brian ,  BREÜNER, Anne ,  ANDERSEN, Rasmus, Lund ,  RASMUSSEN, Michael, Dolberg ,  MICHAELSEN, Soeren

IPC: C12P19/34 ,  C12N9/22 ,  C12N1/20 ,  C12N1/21

CPC classification number: C12P19/34 ,  C12N9/22

Abstract: The present invention relates to RNAse-inactivated Gram positive host cells producing double-stranded RNA (dsRNA) molecules suitable for various applications, including, RNA-interference or gene silencing in one or more target microorganism or organism, such as, plants, insects, nematodes and/or higher animals. The invention also relates to methods of producing dsRNA in the RNAse-inactivated Gram positive host cells and the resulting compositions.