公开(公告)号：WO2019152745A1

公开(公告)日：2019-08-08

申请号：PCT/US2019/016192

申请日：2019-01-31

Applicant: NX PRENATAL INC.

Inventor： BROHMAN, Brian D. ,  ZHANG, Zhen ,  DOSS, Robert C. ,  ROSENBLATT, Kevin Paul

IPC: A61K9/02 ,  A61K31/57 ,  A61K38/18 ,  A61K38/22 ,  A61K45/00 ,  A61P15/06

Abstract: The present disclosure relates to proteomic biomarkers of spontaneous preterm birth, proteomic biomarkers of term birth, and methods of use thereof. In particular, the present disclosure provides tools for determining whether a pregnant subject is at an increased risk for premature delivery, as well as tools for decreasing a pregnant subjects risk for premature delivery. In particular embodiments, highly predictive tests are provided for the detection of spontaneous preterm birth during the first trimester of gestation, in nulliparous pregnant subjects; and other highly predictive tests are provided for detection of spontaneous preterm birth during the first trimester of gestation in pregnant subjects, regardless of parity.

公开(公告)号：WO2017096405A1

公开(公告)日：2017-06-08

申请号：PCT/US2016/065024

申请日：2016-12-05

Applicant: NX PRENATAL INC.

Inventor： BROHMAN, Brian, D. ,  ZHANG, Zhen ,  GOUDY, Kevin, S. ,  DOSS, Robert, C. ,  EZRIN, Alan, M. ,  ROSENBLATT, Kevin, Paul

IPC: C40B30/00 ,  C40B40/10 ,  G01N33/68

CPC classification number: G01N33/689 ,  G01N2800/368 ,  G01N2800/50

Abstract: The present disclosure relates to proteomic biomarkers of spontaneous preterm birth, proteomic biomarkers of term birth, and methods of use thereof. In particular, the present disclosure provides tools for determining whether a pregnant subject is at an increased risk for premature delivery, as well as tools for decreasing a pregnant subject's risk for premature delivery.

Abstract translation: 本公开涉及自发性早产的蛋白质组生物标志物，足月生的蛋白质组生物标志物及其使用方法。 具体而言，本公开提供了用于确定怀孕受试者的早产风险增加的工具，以及用于降低怀孕受试者的早产风险的工具。