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    SYSTEMS AND METHODS FOR HIGH THROUGHPUT SELECTION
    4.
    发明申请
    SYSTEMS AND METHODS FOR HIGH THROUGHPUT SELECTION 审中-公开

    公开(公告)号：WO2020176449A1

    公开(公告)日：2020-09-03

    申请号：PCT/US2020/019607

    申请日：2020-02-25

    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE

    Inventor： WEITZ, David, A. ,  ROSENTHAL, Raoul, Gedalja ,  QU, Liangliang

    IPC: B01J13/02 ,  A01N1/02 ,  A61K9/16 ,  B01F13/00 ,  B01J19/00 ,  C12M1/12 ,  C12N5/00 ,  C40B30/00

    Abstract: The present invention generally relates to systems and methods for high throughput selection. In one aspect, cells are contained within gel droplets, and the cells may interact with the gel droplet in some manner, e.g., to form the gel and/or to degrade the gel. The interaction of cells with the gel droplet may result in some cells being contained within gel droplets and other cells not being contained within gel droplets, which may form the basis by which the cells are sorted. Such cells can be relatively rapidly sorted, e.g., on the basis of size, for example, using filtration, centrifugation, or other similar techniques. In some cases, unlike sorting techniques which can only sort one entity, such as droplets, at a time, such techniques can allow for more than one entity (and in some cases, relatively large numbers of entities) to be simultaneously sorted, dramatically increasing throughput.

    LIBRARIES OF DIVERSE MACROCYCLIC COMPOUNDS AND METHODS OF MAKING AND USING THE SAME
    7.
    发明申请
    LIBRARIES OF DIVERSE MACROCYCLIC COMPOUNDS AND METHODS OF MAKING AND USING THE SAME 审中-公开
    多种大环化合物的库及其制备和使用方法

    公开(公告)号：WO2017197488A1

    公开(公告)日：2017-11-23

    申请号：PCT/CA2017/000128

    申请日：2017-05-16

    Applicant: CYCLENIUM PHARMA INC.

    Inventor： MACDONALD, Dwight ,  DUBÉ, Daniel ,  WAHHAB, Amal ,  THOMAS, Helmut ,  RICHARD, Luc ,  PETERSON, Mark L.

    IPC: C40B40/04 ,  C40B30/00 ,  C40B30/04 ,  C40B30/06 ,  C40B30/08 ,  C40B50/00 ,  G01N33/48 ,  C12Q1/00

    Abstract: The present disclosure relates to novel macrocyclic compounds and libraries thereof that are useful as research tools for drug discovery efforts. This disclosure also relates to methods of preparing these compounds and libraries and methods of using these libraries, such as in high throughput screening. In particular, these libraries are useful for evaluation of bioactivity at existing and newly identified pharmacologically relevant targets, including G protein-coupled receptors, nuclear receptors, enzymes, ion channels, transporters, transcription factors, protein-protein interactions and nucleic acid-protein interactions. As such, these libraries can be applied to the search for new pharmaceutical agents for the treatment and prevention of a range of medical conditions.

    Abstract translation: 本公开涉及新的大环化合物及其文库，其可用作用于药物发现工作的研究工具。 本公开还涉及制备这些化合物和文库的方法以及使用这些文库的方法，例如高通量筛选。 特别是，这些文库可用于评估现有和新鉴定的药理学相关靶点的生物活性，包括G蛋白偶联受体，核受体，酶，离子通道，转运蛋白，转录因子，蛋白质 - 蛋白质相互作用和核酸 - 蛋白质相互作用 。 因此，这些文库可以用于寻找治疗和预防一系列医疗状况的新药物。

    GPR113 GENE ENCODING A G-PROTEIN COUPLED RECEPTOR (GPCR) INVOLVED IN FAT, FATTY ACID AND/OR LIPID ASSOCIATED TASTE AND ASSAYS USING GPR113 FOR IDENTIFYING TASTE MODULATORY COMPOUNDS
    10.
    发明申请
    GPR113 GENE ENCODING A G-PROTEIN COUPLED RECEPTOR (GPCR) INVOLVED IN FAT, FATTY ACID AND/OR LIPID ASSOCIATED TASTE AND ASSAYS USING GPR113 FOR IDENTIFYING TASTE MODULATORY COMPOUNDS 审中-公开
    GPR113基因编码使用GPR113鉴定脂肪酸，脂肪酸和/或脂质相关物质的G蛋白偶联受体（GPCR）和鉴定化合物的测定

    公开(公告)号：WO2016210162A1

    公开(公告)日：2016-12-29

    申请号：PCT/US2016/039065

    申请日：2016-06-23

    Applicant: ROTH, Stacy Markison ,  TOSCHIADDI, Ginger

    Inventor： ROTH, Stacy Markison ,  TOSCHIADDI, Ginger

    IPC: C12Q1/00 ,  C40B30/00 ,  C40B30/06 ,  C40B40/10

    CPC classification number: G01N33/566 ,  G01N33/502 ,  G01N2333/726 ,  G01N2500/00

    Abstract: This invention relates to a gene encoding a GPR113, wherein GPR113 is a taste receptor polypeptide which detects fat tastants. In one embodiment the invention relates to the use of the GPR113 receptor in screening assays for identifying fat, lipid and fatty acid taste modulators or compounds that mimic fat taste. In another embodiment the invention relates a method for reducing dietary preferences for fat containing foods, comprising administering to a subject a compounds which modulates GPR113. In another embodiment the invention relates to comestibles containing an amount of a compound that specifically binds or modulates GPR113 activity, e.g. a GPR113 enhancer or GPR113 blocker, in an amount sufficient to modulate or mimic fat or lipid taste or to affect fat or lipid metabolism.

    Abstract translation: 本发明涉及编码GPR113的基因，其中GPR113是检测脂肪滋味剂的味觉受体多肽。 在一个实施方案中，本发明涉及GPR113受体在用于鉴定模拟脂肪味道的脂肪，脂质和脂肪酸味觉调节剂或化合物的筛选测定中的用途。 在另一个实施方案中，本发明涉及一种用于降低含脂肪食物的饮食偏好的方法，包括向受试者施用调节GPR113的化合物。 在另一个实施方案中，本发明涉及含有一定量的特异性结合或调节GPR113活性的化合物的食物，例如， GPR113增强子或GPR113阻断剂，其量足以调节或模拟脂肪或脂质味道或影响脂肪或脂质代谢。

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