公开(公告)号：WO2018223122A1

公开(公告)日：2018-12-06

申请号：PCT/US2018/035837

申请日：2018-06-04

申请人： OHIO STATE INNOVATION FOUNDATION ,  ACADEMIA SINICA

发明人： CHEN, Ching-Shih ,  HSIEH, Hao-Yu ,  CHUANG, Hsiao-Ching

IPC分类号： A61K31/404 ,  A61P35/00 ,  C07D209/12

CPC分类号： A61P35/00 ,  C07C237/40 ,  C07C2601/02 ,  C07D213/81 ,  C07D213/82

摘要： Disclosed herein are selective HDAC inhibitors. In some embodiments, the compounds are selective HDAC3 inhibitors. The compounds are useful to treat a variety of conditions, including cancers, i.e., breast cancer, cachexia, and liver steatosis.