公开(公告)号：WO2016011558A1

公开(公告)日：2016-01-28

申请号：PCT/CA2015/050692

申请日：2015-07-23

Applicant: ONTARIO INSTITUTE FOR CANCER RESEARCH

Inventor： BARTLETT, John ,  BOUTROS, Paul ,  SABINE, Victoria ,  HAIDER, Syed ,  STARMANS, Maud H.W. ,  YAO, Cindy Qianli ,  WANG, Jianxin

IPC: C40B40/06 ,  C12M1/34 ,  C12Q1/68 ,  C40B30/04 ,  C40B60/00 ,  G01N33/48 ,  G06F19/12 ,  G06F19/20

CPC classification number: C12Q1/6886 ,  A61K31/138 ,  A61K31/5685 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/158 ,  C12Q2600/166 ,  G06F19/00 ,  G06F19/12 ,  G06F19/20 ,  G16H50/30 ,  Y02A90/26

Abstract: Methods, systems, devices and computer impemented methods of prognosing or classifying patients using a biomarker comprising a plurality of subnetwork modules are disclosed. In some embodiments, the method comprises determining an activity of a plurality of genes in a test sample of a patient, wherein the plurality of genes are associated with the plurality of subnetwork modules. An expression profile is constructed using the activity of the plurality of genes. The dysregulation of each of the plurality of subnetwork modules is determined by calculating a score proportional to a degree of dysregulation in each of the plurality of subnetwork modules from the expression profile. The patient is prognosed or classified by inputting each dysregulation score into a model for predicting patient outcomes for patients having a disease, and inputting a clinical indicator of the patient into the model, to obtain a risk associated with the disease.

Abstract translation: 公开了使用包括多个子网模块的生物标志物预测或分类患者的方法，系统，装置和计算机引入的方法。 在一些实施方案中，所述方法包括确定患者的测试样品中的多个基因的活性，其中所述多个基因与所述多个子网模块相关联。 使用多个基因的活性构建表达谱。 多个子网模块中的每个子网模块的失调通过从表情简档中计算与多个子网模块中的每一个中的不正常程度成比例的分数来确定。 通过将每个失调分数输入到用于预测患有疾病的患者的患者结果的模型中，并将患者的临床指标输入到模型中以获得与该疾病相关的风险来预测或分类该患者。