公开(公告)号：WO2020089433A2

公开(公告)日：2020-05-07

申请号：PCT/EP2019/079916

申请日：2019-10-31

申请人： OSPEDALE SAN RAFFAELE S.R.L

发明人： BONINI, Maria Chiara ,  RUGGIERO, Eliana ,  MAGNANI, Zulma Irene ,  CICERI, Fabio ,  CARNEVALE, Erica

IPC分类号： C07K14/725 ,  A61K35/17

摘要： A T-cell receptor (TCR), which binds to a Wilms tumour 1 protein (WT1) peptide when presented by a major histocompatibility complex (MHC).

公开(公告)号：WO2021219758A1

公开(公告)日：2021-11-04

申请号：PCT/EP2021/061198

申请日：2021-04-28

申请人： OSPEDALE SAN RAFFAELE S.R.L.

发明人： CAMISA, Barbara ,  CASUCCI, Monica ,  ARCANGELI, Silvia ,  MEZZANOTTE, Claudia ,  FALCONE, Laura ,  BONINI, Maria Chiara

IPC分类号： C12N5/0783 ,  A61K39/00 ,  A61K2039/5156 ,  A61K2039/5158 ,  A61K39/001112 ,  A61P35/00 ,  A61P35/02 ,  C07K14/7051 ,  C07K16/2803 ,  C07K2317/622 ,  C07K2319/03 ,  C07K2319/33 ,  C12N2501/2307 ,  C12N2501/515 ,  C12N2510/00 ,  C12N5/0636

摘要： The present invention refers to a method to produce a T cell with advantageous properties. The invention also refers to a T cell or an engineered T cell produced by the method and its use in therapy.

公开(公告)号：WO2020089433A3

公开(公告)日：2020-05-07

申请号：PCT/EP2019/079916

申请日：2019-10-31

申请人： OSPEDALE SAN RAFFAELE S.R.L

发明人： BONINI, Maria Chiara ,  RUGGIERO, Eliana ,  MAGNANI, Zulma Irene ,  CICERI, Fabio ,  CARNEVALE, Erica

IPC分类号： C07K14/725 ,  A61K35/17

摘要： A T-cell receptor (TCR), which binds to a Wilms tumour 1 protein (WT1) peptide when presented by a major histocompatibility complex (MHC).

公开(公告)号：WO2022167694A1

公开(公告)日：2022-08-11

申请号：PCT/EP2022/053040

申请日：2022-02-08

申请人： OSPEDALE SAN RAFFAELE S.R.L. ,  FONDAZIONE CENTRO SAN RAFFAELE

发明人： BONINI, Maria Chiara ,  CIANCIOTTI, Beatrice Claudia ,  RUGGIERI, Eliana ,  POTENZA, Alessia

IPC分类号： C12N15/113 ,  A61K39/00 ,  A61P35/00

摘要： The present invention is related to an isolated guide ribonucleic acid (gRNA) comprising a guide sequence targeting an inhibitory receptor (IR), a TCR α (TRAC) constant region or a β chain (TRBC1/2) constant region target sequence, wherein said guide sequence is selected from the group consisting of SEQ ID NOs:1-27, 122-126 and combinations thereof.

公开(公告)号：WO2018197492A1

公开(公告)日：2018-11-01

申请号：PCT/EP2018/060477

申请日：2018-04-24

申请人： OSPEDALE SAN RAFFAELE S.R.L. ,  FONDAZIONE CENTRO SAN RAFFAELE

发明人： BONINI, Maria Chiara ,  RUGGIERO, Eliana ,  MAGNANI, Zulma Irene ,  VAGO, Luca Aldo Edoardo ,  BONDANZA, Attilio ,  CICERI, Fabio

IPC分类号： C07K14/725 ,  C07K14/47

摘要： TCR AND PEPTIDES A T-cell receptor (TCR), which binds to a Wilms tumour 1 protein (WT1) peptide when presented by a major histocompatibility complex (MHC).