公开(公告)号：WO2021078971A2

公开(公告)日：2021-04-29

申请号：PCT/EP2020/079954

申请日：2020-10-23

Applicant: OXFORD NANOPORE TECHNOLOGIES LIMITED

Inventor： ORTIZ BAHAMON, Pedro, Miguel ,  MACKETT, Paul, Raymond ,  GREASTY, Robert ,  MCKENDRY, Jonathan, Edward ,  HYDE, Jason, Robert ,  JACKSON, Mark, David ,  WILTSHIRE, Richard, Kenneth, John ,  DAVIES, Rhodri, Rhys ,  HYLAND, Mark ,  CLARKE, James, Anthony ,  SANGHERA, Gurdial, Singh

IPC: G01N33/487 ,  B01L3/00 ,  B01L2200/025 ,  B01L2200/12 ,  B01L2300/0645 ,  B01L2300/0663 ,  B01L3/5085 ,  G01N33/48721

Abstract: The invention relates to a method of forming a sensing device (100) for supporting a plurality of nanopores upon an array of wells (10). The method involves providing a substrate, said substrate (102) having a surface (104) having an array of electrodes (6) located thereon for connecting to or for configuring upon an electronic circuit. Separately, a well array structure (108) is provided, which has an array of walls (110) defining through-holes (112) for defining wells (10). The substrate (102) and the well array structure (108) are aligning said array of electrodes (6) to define, at least in part, a portion of the bases of respective wells (10) at the bottom of the through holes (112).

公开(公告)号：WO2021255414A1

公开(公告)日：2021-12-23

申请号：PCT/GB2021/051029

申请日：2021-04-29

Applicant: OXFORD NANOPORE TECHNOLOGIES LIMITED

Inventor： XIE, Ping ,  MILLIS, Justin ,  HEALY, Ken ,  CLARKE, James Anthony ,  HYDE, Jason Robert ,  WILTSHIRE, Richard Kenneth John ,  MCKENDRY, Jonathan Edward ,  GREASTY, Robert ,  BROWN, Clive Gavin ,  PERA, Ioana ,  SANGHERA, Gurdial Singh ,  HYLAND, Mark ,  ORTIZ BAHAMON, Pedro Miguel ,  JACKSON, Mark David ,  MACKETT, Paul Raymond ,  DAVIES, Rhodri Rhys

IPC: G01N33/487 ,  G01N33/48721

Abstract: There is disclosed a nanopore support structure comprising a wall layer comprising walls defining a plurality of wells, and overhangs extending from the walls across each of the wells, the overhang defining an aperture configured to support a membrane suitable for insertion of a nanopore. There is further disclosed a nanopore sensing device comprising a nanopore support structure, and methods of manufacturing the nanopore support structure and the nanopore sensing device.