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    APPARATUS FOR SUPPORTING AN ARRAY OF LAYERS OF AMPHIPHILIC MOLECULES AND METHOD OF FORMING AN ARRAY OF LAYERS OF AMPHIPHILIC MOLECULES
    2.
    发明申请
    APPARATUS FOR SUPPORTING AN ARRAY OF LAYERS OF AMPHIPHILIC MOLECULES AND METHOD OF FORMING AN ARRAY OF LAYERS OF AMPHIPHILIC MOLECULES 审中-公开
    用于支持大分子分子层阵列的装置和形成大分子层的阵列的方法

    公开(公告)号：WO2013121193A2

    公开(公告)日：2013-08-22

    申请号：PCT/GB2013/050333

    申请日：2013-02-13

    Applicant: OXFORD NANOPORE TECHNOLOGIES LIMITED

    Inventor： HYDE, Jason Robert ,  CLARKE, James Anthony ,  ANDREATTA, Gaëlle Anne-Leonie

    IPC: G01N33/487

    CPC classification number: G01N33/48721

    Abstract: An apparatus for supporting an array of layers of amphiphilic molecules, the apparatus comprising: a body,formed in a surface of the body, an array of sensor wells capable of supporting a layer of amphiphilic molecules across the sensor wells, the sensor wells each containing an electrode for connection to an electrical circuit, and formed in the surface of the body between the sensor wells, flow control wells capable of smoothing the flow of a fluid across the surface.

    Abstract translation: 一种用于支撑两亲性分子层阵列的装置，所述装置包括：形成在身体表面的主体，能够跨越传感器孔支撑一层两亲分子的传感器孔阵列，每个传感器孔包含 用于连接到电路的电极，并且形成在传感器井之间的主体表面中，能够平滑流过表面的流体的流量控制孔。

    FORMATION OF ARRAY OF MEMBRANES AND APPARATUS THEREFOR
    3.
    发明申请
    FORMATION OF ARRAY OF MEMBRANES AND APPARATUS THEREFOR 审中-公开
    膜的阵列的形成及其装置

    公开(公告)号：WO2014064443A2

    公开(公告)日：2014-05-01

    申请号：PCT/GB2013/052766

    申请日：2013-10-23

    Applicant: OXFORD NANOPORE TECHNOLOGIES LIMITED

    Inventor： HYDE, Jason Robert ,  BAHAMON, Pedro Miguel Ortiz ,  BROWN, Clive Gavin ,  HERON, Andrew John ,  MACKETT, Paul Raymond

    IPC: B01J19/00

    CPC classification number: B01J19/0046 ,  B01J2219/00313 ,  B01J2219/00317 ,  B01J2219/00351 ,  B01J2219/00585 ,  B01J2219/00659 ,  B01J2219/00734 ,  B01J2219/00736 ,  B01L3/5088 ,  B01L2200/0642 ,  B01L2400/086 ,  C12Q1/6869 ,  G01N33/48721 ,  G01N33/573 ,  G01N2333/974

    Abstract: An array of membranes comprising amphipathic moleculesis formed using an apparatus comprising a support defining an array of compartments. Volumes comprising polar medium are provided within respective compartments and a layer comprising apolar medium is provided extending across the openings with the volumes. Polar medium is flowed across the support to displace apolar medium and form a layer in contact with the volumes, forming membranes comprising amphipathic molecules at the interfaces. In one construction of the apparatus, the support that comprises partitions which comprise inner portions and outer portions. The inner portions define inner recesses without gaps therebetween that are capable of constraining the volumes comprising polar medium contained in neighbouring inner recesses from contacting each other. The outer portions extend outwardly from the inner portions and have gaps allowing the flow of an apolar medium across the substrate.

    Abstract translation: 包含两性分子的膜阵列使用包含限定隔室阵列的支持物的设备形成。 包含极性介质的体积设置在相应的隔室内，并且提供包括非极性介质的层延伸穿过具有体积的开口。 极性介质流过载体以置换非极性介质并形成与体积接触的层，从而在界面处形成包含两亲分子的膜。 在该设备的一种构造中，支撑件包括包括内部部分和外部部分的分隔部。 内部限定内部凹部，所述内部凹部之间没有间隙，所述内部凹部能够限制容纳在相邻内部凹部中的包含极性介质的体积彼此接触。 外部从内部向外延伸并具有允许非极性介质流过衬底的间隙。

    DROPLET INTERFACES
    4.
    发明申请
    DROPLET INTERFACES 审中-公开
    DROPLET接口

    公开(公告)号：WO2014064444A1

    公开(公告)日：2014-05-01

    申请号：PCT/GB2013/052767

    申请日：2013-10-23

    Applicant: OXFORD NANOPORE TECHNOLOGIES LIMITED

    Inventor： HERON, Andrew John ,  HYDE, Jason Robert ,  BROWN, Clive Gavin

    IPC: B01D69/00 ,  C12Q1/68 ,  G01N33/50

    CPC classification number: G01N33/48721 ,  B01D67/0023 ,  B01D69/122 ,  B01D71/26 ,  B01D71/32 ,  B01D71/58 ,  B01D71/70 ,  B01D71/80 ,  B01D2323/35 ,  B01D2325/36 ,  B01D2325/38 ,  C12Q1/6869 ,  G01N33/50 ,  Y10T436/145555 ,  C12Q2565/631

    Abstract: The invention provides a method of forming a membrane between a first volume of polar medium and a second volume of polar medium, which method comprises: (a) providing a first volume comprising polar medium and a second volume comprising polar medium which are separated from one another by an apolar medium, wherein at least one of said first and second volumes comprises a layer comprising amphipathic molecules, at the interface between the polar medium and the apolar medium, wherein each of the amphipathic molecules comprises a first outer hydrophilic group, a hydrophobic core group, and a second outer hydrophilic group, wherein each of the first and second outer hydrophilic groups is linked to the hydrophobic core group; and (b) causing the first and second volumes to come into contact with one another to form a membrane comprising said amphipathic molecules between the first and second volumes. The invention also provides a system comprising a membrane between a first volume of a polar medium; and a second volume of a polar medium, which membrane comprises the amphipathic molecules, and wherein the first volume of polar medium is within an apolar medium.

    Abstract translation: 本发明提供了一种在第一体积的极性介质和第二体积的极性介质之间形成膜的方法，该方法包括：（a）提供包含极性介质的第一体积和包含极性介质的第二体积，所述极性介质与第一体积的极性介质分离 另一个通过非极性介质，其中所述第一和第二体积中的至少一个包含在极性介质和非极性介质之间的界面处的包含两亲性分子的层，其中每个两亲性分子包含第一外部亲水基团，疏水性 核心基团和第二外部亲水基团，其中第一和第二外部亲水基团中的每一个连接到疏水性核心基团; 和（b）使第一和第二体积彼此接触以形成包含第一和第二体积之间的所述两亲分子的膜。 本发明还提供一种系统，其包括在第一体积的极性介质之间的膜; 和第二体积的极性介质，所述膜包含两亲性分子，并且其中所述第一体积的极性介质在非极性介质内。

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