公开(公告)号：WO2018094253A9

公开(公告)日：2018-05-24

申请号：PCT/US2017/062375

申请日：2017-11-17

Applicant: PACIRA PHARMACEUTICALS, INC.

Inventor： LOS, Kathleen Dunne Albright ,  GARCIA, Louie Daniel ,  KURZ, Stephanie ,  STONE, Katherine ,  SCHUTT, Ernest George ,  KHARITONOV, Vladimir

IPC: C07D417/12 ,  B02C23/06

Abstract: Embodiments of the present disclosure are related to multivesicular liposome formulations encapsulating zinc meloxicam complex microparticles. Methods of making the zinc meloxicam complex microparticles and administering the zinc meloxicam complex microparticles encapsulated in multivesicular liposome formulations and their use as medicaments are also provided.

公开(公告)号：WO2021141956A

公开(公告)日：2021-07-15

申请号：PCT/US2021/012266

申请日：2021-01-06

Applicant: PACIRA PHARMACEUTICALS, INC, [US]/[US] ,  WINSTON, Roy [US]/[US] ,  SCRANTON, Richard [US]/[US] ,  LOS, Kathy [US]/[US] ,  KHARITONOV, Vladimir [US]/[US]

Inventor： WINSTON, Roy ,  SCRANTON, Richard ,  LOS, Kathy ,  KHARITONOV, Vladimir

IPC: A61K9/00

Abstract: In some embodiments provided herein is a method of treating pain associated with cesarean section surgery in a subject, the method comprising administering into the subject a pharmaceutical composition comprising: a) a multivesicular liposome comprising: at least one amphipathic lipid, and at least one neutral lipid; and b) an aqueous phase comprising bupivacaine phosphate, wherein the aqueous phase is encapsulated within the multivesicular liposome.

公开(公告)号：WO2021141959A1

公开(公告)日：2021-07-15

申请号：PCT/US2021/012269

申请日：2021-01-06

Applicant: PACIRA PHARMACEUTICALS, INC. ,  LOS, Kathy ,  KHARITONOV, Vladimir

Inventor： LOS, Kathy ,  KHARITONOV, Vladimir

IPC: A61K31/445 ,  A61K47/22 ,  A61K47/24

Abstract: In some embodiments provided herein is a method of treating pain, the method comprising administering into the subject a pharmaceutical composition comprising multivesicular liposomes encapsulating bupivacaine phosphate, said multivesicular liposomes comprising bupivacaine or a salt thereof; phosphoric acid; a lipid component comprising at least one amphipathic lipid and at least one neutral lipid lacking a hydrophilic head group.

公开(公告)号：WO2016118652A1

公开(公告)日：2016-07-28

申请号：PCT/US2016/014169

申请日：2016-01-20

Applicant: PACIRA PHARMACEUTICALS, INC.

Inventor： LOS, Kathleen D.A. ,  GARCIA, Louie Daniel ,  KURZ, Stephanie ,  KHARITONOV, Vladimir

IPC: A61K31/195 ,  A61K9/127

CPC classification number: A61K31/195 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/127 ,  A61K9/1277 ,  A61K47/02 ,  A61K47/12 ,  A61K47/18 ,  A61K47/183 ,  A61P7/04

Abstract: Some embodiments of the present application are related to multivesicular liposome formulations comprising tranexamic acid (TXA) for the purpose of minimizing the side effects of unencapsulated tranexamic while maintaining or improving efficacy and lengthening the duration of the effect. Methods of making and administering the tranexamic acid encapsulated multivesicular liposome formulations and their use as medicaments are also provided.

Abstract translation: 本申请的一些实施方案涉及包含凝血酸（TXA）的多泡脂质体制剂，其目的是使未包封的氨甲环酸的副作用最小化，同时保持或改善功效并延长效果的持续时间。 还提供了制备和施用凝血酸封装的多泡脂质体制剂的方法及其作为药物的用途。

公开(公告)号：WO2021141963A1

公开(公告)日：2021-07-15

申请号：PCT/US2021/012275

申请日：2021-01-06

Applicant: PACIRA PHARMACEUTICALS, INC. ,  WINSTON, Roy ,  LOS, Kathy ,  KHARITONOV, Vladimir

Inventor： WINSTON, Roy ,  LOS, Kathy ,  KHARITONOV, Vladimir

IPC: A61K31/167 ,  A61K31/445 ,  A61K9/127 ,  A61P23/02

Abstract: In some embodiments provided herein is a method of treating pain, the method comprising injecting into the subarachnoid space of the subject a pharmaceutical composition comprising: a) a multivesicular liposome comprising: at least one amphipathic lipid, and at least one neutral lipid; and b) an aqueous phase comprising bupivacaine phosphate, wherein the aqueous phase is encapsulated within the multivesicular liposome.

公开(公告)号：WO2018094253A1

公开(公告)日：2018-05-24

申请号：PCT/US2017/062375

申请日：2017-11-17

Applicant: PACIRA PHARMACEUTICALS, INC.

Inventor： GARCIA, Louie, Daniel ,  SCHUTT, Ernest, George ,  KHARITONOV, Vladimir ,  KURZ, Stephanie ,  LOS, Kathleen Dunne, Albright ,  STONE, Katherine

IPC: C07D417/12 ,  B02C23/06

Abstract: Embodiments of the present disclosure are related to multivesicular liposome formulations encapsulating zinc meloxicam complex microparticles. Methods of making the zinc meloxicam complex microparticles and administering the zinc meloxicam complex microparticles encapsulated in multivesicular liposome formulations and their use as medicaments are also provided.