公开(公告)号：WO2016012965A3

公开(公告)日：2016-01-28

申请号：PCT/IB2015/055572

申请日：2015-07-23

Applicant: PIRAMAL ENTERPRISES LIMITED

Inventor： KUMAR, Sanjay ,  SHARMA, Rajiv ,  DEORE, Vijaykumar, Bhagwan ,  YEWALKAR, Nilambari Nilkanth

IPC: C07C59/72 ,  C07C255/46 ,  C07D215/14 ,  C07D277/60 ,  C07C255/50 ,  C07D213/73 ,  C07D307/80 ,  C07D333/16 ,  C07D309/24 ,  C07D405/14 ,  C07D405/04 ,  C07D413/10 ,  A61K31/4433 ,  A61K31/444 ,  A61K31/5377 ,  A61K31/351 ,  A61K31/192 ,  A61K31/4418 ,  A61K31/343 ,  A61K31/381 ,  A61K31/277 ,  A61K31/428 ,  A61P3/10 ,  A61P3/04 ,  A61P3/06

Abstract: The present invention relates to substituted phenyl alkanoic acid compounds designated as the compound of Formula (I) (as described herein) or a tautomer, a stereoisomer, a geometrical isomer, a pharmaceutically acceptable salt, a pharmaceutically acceptable solvate, a prodrug, a polymorph, an N-oxide, a S-oxide or a carboxylic acid isostere thereof; which are GPR120 agonists. The present invention also relates to a pharmaceutical composition of compound of Formula (I) for the treatment of diseases or discorder mediated by GPR120.

公开(公告)号：WO2014141118A1

公开(公告)日：2014-09-18

申请号：PCT/IB2014/059719

申请日：2014-03-13

Applicant: PIRAMAL ENTERPRISES LIMITED

Inventor： KUMAR, Sanjay ,  SHARMA, Rajiv ,  DEORE, Vijaykumar, Bhagwan ,  YEWALKAR, Nilambari, Nilkanth

IPC: C07D471/04 ,  A61K31/437 ,  A61P35/00

CPC classification number: C07D471/04

Abstract: The present invention relates to substituted imidazo[4,5-c]quinoline derivatives represented by the compounds formula (I), processes for their preparation, pharmaceutical compositions comprising said compounds and their use in the treatment of diseases or disorders mediated by one or more kinases (such as PI3 kinase, mTOR and ALK-1), particularly proliferative diseases or disorders such as cancer. The compounds of formula (I) can also be used in the treatment of inflammation, angiogenesis related disorders and bacterial infections.

Abstract translation: 本发明涉及由式（I）化合物代表的取代的咪唑并[4,5-c]喹啉衍生物，其制备方法，包含所述化合物的药物组合物及其在治疗由一种或多种 激酶（如PI3激酶，mTOR和ALK-1），特别是增殖性疾病或疾病如癌症。 式（I）化合物也可用于治疗炎症，血管生成相关病症和细菌感染。