公开(公告)号：WO2011039554A3

公开(公告)日：2011-04-07

申请号：PCT/HU2010/000103

申请日：2010-09-29

Applicant: EGIS GYÓGYSZERGYÁR NYILVÁNOSAN MŰKÖDŐ RÉSZVÉNYTÁRSAGÁG ,  FETTER, József ,  BERTHA, Ferenc ,  MOLNAR, Balázs ,  SIMIG, Gyula ,  BARKÓCZY, József ,  VOLK, Balázs ,  LÉVAY, György ,  GACSÁLYI, István ,  GIGLER, Gábor ,  KOMPAGNE, Hajnalka ,  MARKÓ, Bernadett ,  NAGY, Katalin ,  KIRICSI, Péter ,  HÁRSING, László, Gábor ,  SZÉNÁSI, Gábor

Inventor： FETTER, József ,  BERTHA, Ferenc ,  MOLNAR, Balázs ,  SIMIG, Gyula ,  BARKÓCZY, József ,  VOLK, Balázs ,  LÉVAY, György ,  GACSÁLYI, István ,  GIGLER, Gábor ,  KOMPAGNE, Hajnalka ,  MARKÓ, Bernadett ,  NAGY, Katalin ,  KIRICSI, Péter ,  HÁRSING, László, Gábor ,  SZÉNÁSI, Gábor

IPC: C07D285/06 ,  C07D285/36 ,  C07D309/24 ,  A61K31/554 ,  A61P25/00

Abstract: The present invention relates to compounds 2,3,4-benzothiadiazepine-2,2-dioxide derivatives and enantiomers of the general Formula (I) wherein 'a' represents single or double bond, R 1 and R 2 represent, independently, hydrogen, halogen, cyano, alkyl, alkoxy, trifluoromethyl, or if 'a' represents single bond, R 1 and R 2 together form =N-S-N= group, R 3 and R 4 represent, independently, hydrogen, alkyl, alkenyl, cycloalkyl, aryl or aralkyl, R 5 and R 6 represent, independently, hydrogen, halogen, cyano, alkyl, alkoxy, trifluoromethyl and/or enantiomers and/or pharmaceutically suitable acid addition salts thereof. The invention further relates to a process for their preparation, medicaments containing said compounds and the use thereof for the treatment of disorders of the central nervous system.

公开(公告)号：WO2016012965A3

公开(公告)日：2016-01-28

申请号：PCT/IB2015/055572

申请日：2015-07-23

Applicant: PIRAMAL ENTERPRISES LIMITED

Inventor： KUMAR, Sanjay ,  SHARMA, Rajiv ,  DEORE, Vijaykumar, Bhagwan ,  YEWALKAR, Nilambari Nilkanth

IPC: C07C59/72 ,  C07C255/46 ,  C07D215/14 ,  C07D277/60 ,  C07C255/50 ,  C07D213/73 ,  C07D307/80 ,  C07D333/16 ,  C07D309/24 ,  C07D405/14 ,  C07D405/04 ,  C07D413/10 ,  A61K31/4433 ,  A61K31/444 ,  A61K31/5377 ,  A61K31/351 ,  A61K31/192 ,  A61K31/4418 ,  A61K31/343 ,  A61K31/381 ,  A61K31/277 ,  A61K31/428 ,  A61P3/10 ,  A61P3/04 ,  A61P3/06

Abstract: The present invention relates to substituted phenyl alkanoic acid compounds designated as the compound of Formula (I) (as described herein) or a tautomer, a stereoisomer, a geometrical isomer, a pharmaceutically acceptable salt, a pharmaceutically acceptable solvate, a prodrug, a polymorph, an N-oxide, a S-oxide or a carboxylic acid isostere thereof; which are GPR120 agonists. The present invention also relates to a pharmaceutical composition of compound of Formula (I) for the treatment of diseases or discorder mediated by GPR120.

公开(公告)号：WO99019318A1

公开(公告)日：1999-04-22

申请号：PCT/JP1998/004524

申请日：1998-10-07

IPC: A01N43/653 ,  A01N47/34 ,  C07D309/22 ,  C07D309/24 ,  C07D309/30 ,  C07D311/24 ,  C07D311/44 ,  C07D311/56 ,  C07D335/06 ,  C07D405/04 ,  C07D311/22 ,  C07D311/54 ,  C07D409/04

CPC classification number: C07D335/06 ,  A01N43/653 ,  C07D309/22 ,  C07D309/24 ,  C07D309/30 ,  C07D405/04

Abstract: Novel substituted chromone compounds which are intermediates for chromone compounds useful as bactericides and herbicides. Specifically, substituted chromone compounds represented by general formula (1) wherein R represents hydrogen, C1-6 alkyl, etc.; R represents hydrogen or C1-6 alkyl; R represents halogeno, etc.; R represents hydrogen, halogeno, etc.; R represents hydrogen, C1-6 alkyl, etc.; X represents oxygen or sulfur; and A represents nitro, etc.

Abstract translation: 新颖的取代色酮化合物，其是用作色酮化合物的中间体，可用作杀菌剂和除草剂。 具体来说，由通式（1）表示的取代的色酮化合物，其中R 1表示氢，C 1-6烷基等; R 2表示氢或C 1-6烷基; R 3表示卤素等。 R 4表示氢，卤素等; R 5表示氢，C 1-6烷基等; X表示氧或硫; A代表硝基等

公开(公告)号：WO2010097374A1

公开(公告)日：2010-09-02

申请号：PCT/EP2010/052236

申请日：2010-02-23

Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH ,  MACK, Jürgen ,  CECI, Angelo ,  DOODS, Henri ,  HAUEL, Norbert ,  KONETZKI, Ingo ,  PRIEPKE, Henning ,  SCHULER-METZ, Annette ,  WALTER, Rainer

Inventor： MACK, Jürgen ,  CECI, Angelo ,  DOODS, Henri ,  HAUEL, Norbert ,  KONETZKI, Ingo ,  PRIEPKE, Henning ,  SCHULER-METZ, Annette ,  WALTER, Rainer

IPC: C07D209/20 ,  C07D211/66 ,  C07D239/28 ,  C07D307/24 ,  C07D309/24 ,  C07D333/38 ,  C07D405/12 ,  C07D237/08 ,  C07D237/24 ,  A61K31/165 ,  A61K31/38 ,  A61K31/435 ,  A61K31/505 ,  A61K31/506

CPC classification number: C07D333/38 ,  C07C237/22 ,  C07C237/24 ,  C07C271/22 ,  C07C275/16 ,  C07C2601/08 ,  C07D209/20 ,  C07D211/66 ,  C07D239/28 ,  C07D307/24 ,  C07D309/14 ,  C07D405/12

Abstract: Gegenstand der vorliegenden Erfindung sind Verbindungen der allgemeinen Formel (I), in der n, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 und R 8 wie in der Beschreibung erwähnt definiert sind, deren Enantiomere, deren Diastereomere, deren Gemische und deren Salze, insbesondere deren physiologisch verträgliche Salze mit organischen oder anorganischen Säuren oder Basen, welche wertvolle Eigenschaften aufweisen, deren Herstellung, die die pharmakologisch wirksamen Verbindungen enthaltenden Arzneimittel, deren Herstellung und deren Verwendung.

Abstract translation: 本发明涉及通式（I）的化合物如上所定义，其中n，R1，R2，R3，R4，R5，R6，R7和R8中的描述中，对映体，非对映体，它们的混合物和 盐，尤其是其与有机或无机酸或碱，其具有有价值的性质生理学上相容的盐，它们的制备，所述药物组合物的药理学上有效的化合物，它们的制备和它们的用途。

公开(公告)号：WO00014033A1

公开(公告)日：2000-03-16

申请号：PCT/GB1999/002973

申请日：1999-09-08

IPC: C07B53/00 ,  C07C41/03 ,  C07D307/28 ,  C07D309/24 ,  C07D313/04 ,  C07D317/12 ,  C07D317/38

CPC classification number: C07D317/12 ,  C07B53/00 ,  C07C41/03 ,  C07D307/28 ,  C07D309/24 ,  C07D313/04 ,  C07D317/38 ,  C07C43/178 ,  C07C43/23 ,  C07C43/1787

Abstract: Nucleophilic oxygen species, such as primary alcohols, carboxylates, and water, are added to vinyl epoxides in a highly regioselective and enantioselective manner, providing a convenient route to enantiomerically enriched 2,2-diols and oxygen-containing heterocycles. The reaction employs a chireal Pd(0) complex and a borane or borate as co-catalysts. Also described are similar additions of nitrogen nucleophils, and the addition of carbonates to vinyl epoxides using a chiral Pd(0) catalyst.

Abstract translation: 将亲核氧，如伯醇，羧酸盐和水以高度区域选择性和对映选择性的方式添加到乙烯基环氧化物中，为对映体富集的2,2-二醇和含氧杂环提供了方便的途径。 该反应采用chireal Pd（0）络合物和硼烷或硼酸盐作为助催化剂。 还描述了类似的氮亲核物的添加，以及使用手性Pd（0）催化剂将碳酸酯加成到乙烯基环氧化物中。