公开(公告)号：WO2023060051A1

公开(公告)日：2023-04-13

申请号：PCT/US2022/077493

申请日：2022-10-04

Applicant: PLANTVAX, INC.

Inventor： ROSENBERG, Yvonne

IPC: A61P31/14 ,  A61K39/00 ,  C07K16/10 ,  A61K2039/505 ,  C07K16/1063 ,  C07K2317/13 ,  C07K2317/21 ,  C07K2317/41 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/72 ,  C07K2317/90

Abstract: Disclosed herein are methods of producing a therapeutic plant antibody or fragment thereof, which is produced in a plant or plant cell to provide a plant antibody or fragment thereof that is unable to substantially cross the placenta if administered to a pregnant mother, but that if produced in a mammal or mammalian cell may cross the placenta and potentially result in damage to a foetus or newborn if administered to a pregnant mother, and so is suitable for use in pregnant subjects. The therapeutic plant antibody can also be used in compositions and medicaments for treating various conditions.

公开(公告)号：WO2016123569A2

公开(公告)日：2016-08-04

申请号：PCT/US2016/015813

申请日：2016-01-29

Applicant: PLANTVAX, INC.

Inventor： ROSENBERG, Yvonne

IPC: A61K39/42 ,  C12N15/82

CPC classification number: A61K39/42 ,  C12N15/8258

Abstract: Monoclonal antibodies produced in plants at high levels wherein elimination of L chain glycans improves plasma stability of certain plant derived bnAbs are provided. Monoclonal antibodies produced in plants which exhibit no or reduced immunogenicity after multiple injections are provided. Methods of production of the foregoing are provided. Methods of determining immunogenicity assessing the immunogenicity and neutralizing ability of the same are provided. Methods of treating HIV using monoclonal antibodies produced in plants are also provided.

Abstract translation: 提供了在高水平植物中产生的单克隆抗体，其中消除L链聚糖改善某些植物衍生的bnAb的血浆稳定性。 提供了在多次注射后不显示或降低的免疫原性的植物中产生的单克隆抗体。 提供了前述的生产方法。 提供了评估其免疫原性和中和能力的免疫原性的方法。 还提供了使用在植物中产生的单克隆抗体来治疗HIV的方法。