公开(公告)号：WO2019222741A1

公开(公告)日：2019-11-21

申请号：PCT/US2019/033123

申请日：2019-05-20

Applicant: PNEUMRX, INC.

Inventor： RODRIGUEZ, Verna ,  HONG, Kinman

IPC: A61B17/12 ,  A61B1/00 ,  A61B17/00 ,  A61B17/10 ,  A61F2/04

Abstract: The invention provides improved medical devices, therapeutic treatment systems, and treatment methods for treatment of the lung. The invention includes methods, systems, and devices for applying a first lung volume reduction action to the functionally impaired lung tissue so as to reduce its volume to less than a pre-treatment volume; and applying a pro-inflammatory stimulus to the functionally impaired lung tissue having reduced volume, that stimulus being sufficient to induce fibrosis in the functionally impaired lung tissue. The pro-inflammatory stimulus may be separate and additional to that of the lung volume reduction action.

公开(公告)号：WO2020081698A3

公开(公告)日：2020-04-23

申请号：PCT/US2019/056558

申请日：2019-10-16

Applicant: PNEUMRX, INC.

Inventor： RODRIGUEZ, Verna

IPC: A61B5/08 ,  A61B6/03 ,  G16H30/40

Abstract: Systems and methods for developing a lung volume reduction treatment plan for a patient include developing a first personalized three-dimensional pulmonary model for the patient based on a computerized tomography (CT) scan of the lung of the patient and a validated computational pulmonary system model, selecting a first lung coil design and a first lung coil placement location, developing a second personalized three-dimensional pulmonary model for the patient based on the first personalized three-dimensional pulmonary model for the patient, the first lung coil design, and the first lung coil placement location, and selecting a second lung coil design and a second lung coil placement location, where the selection of the second lung coil placement location is based on the second personalized three-dimensional pulmonary model for the patient.

公开(公告)号：WO2020081698A2

公开(公告)日：2020-04-23

申请号：PCT/US2019/056558

申请日：2019-10-16

Applicant: PNEUMRX, INC.

Inventor： RODRIGUEZ, Verna

IPC: G16H50/20

Abstract: Systems and methods for developing a lung volume reduction treatment plan for a patient include developing a first personalized three-dimensional pulmonary model for the patient based on a computerized tomography (CT) scan of the lung of the patient and a validated computational pulmonary system model, selecting a first lung coil design and a first lung coil placement location, developing a second personalized three-dimensional pulmonary model for the patient based on the first personalized three-dimensional pulmonary model for the patient, the first lung coil design, and the first lung coil placement location, and selecting a second lung coil design and a second lung coil placement location, where the selection of the second lung coil placement location is based on the second personalized three-dimensional pulmonary model for the patient.

公开(公告)号：WO2018060848A1

公开(公告)日：2018-04-05

申请号：PCT/IB2017/055847

申请日：2017-09-26

Applicant: PNEUMRX INC.

Inventor： MATHIS, Mark ,  RODRIGUEZ, Verna ,  MACHOLD, Timothy ,  KAARTO, Scott

IPC: A61M25/09

Abstract: A guidewire suitable for use in a system for implanting a lung volume reduction device comprises: an outer sheath having a proximal end and a distal end, and comprising a proximal section, a transition section, and a distal section, wherein the proximal section extends from the proximal end of the outer sheath to the transition section, and the distal section extends from the transition section to the distal end of the outer sheath, and wherein the distal section defines a bore extending from the transition section to the distal end of the outer sheath; and an inner core having a proximal end and a distal end, wherein the inner core extends through the bore of the distal section of the outer sheath, wherein the inner core is fixed to the outer sheath at the transition section, and wherein the distal end of the inner core is fixed to the distal end of the outer sheath at the distal end of the sheath.

Abstract translation: 适用于植入肺减容装置的系统中的导丝包括：具有近端和远端的外护套，并且包括近端部分，过渡部分和远端 其中近端部分从外护套的近端延伸到过渡部分，并且远端部分从过渡部分延伸到外护套的远端，并且其中远端部分限定从过渡部分延伸的孔 截面到外鞘的远端; 以及具有近端和远端的内芯，其中内芯延伸穿过外护套的远端部分的孔，其中内芯在过渡部分处固定到外护套，并且其中远端 的内芯固定在护套远端的外护套的远端。

公开(公告)号：WO2018060795A1

公开(公告)日：2018-04-05

申请号：PCT/IB2017/055431

申请日：2017-09-08

Applicant: PNEUMRX INC.

Inventor： LEHRBERG, David ,  MATHIS, Mark ,  ETTER, Jeffrey ,  RODRIGUEZ, Verna

IPC: A61B17/12 ,  A61C15/04 ,  A61B50/30

Abstract: A container for a medical device having a housing defining a cavity for receiving the device, a coupling zone external to the cavity, and an exit aperture between the cavity and the coupling zone; and a bearing surface located within the cavity, the bearing surface, exit aperture and coupling zone defining an exit path along which the device can be moved for deployment from the container. The bearing surface is spaced from the exit aperture and arranged, together with the coupling zone, such that the exit path is substantially straight. The cavity is approximately cylindrical, and the bearing surface, the exit aperture, and the coupling zone are aligned such that the exit path extends in a direction that is substantially tangential to the cavity. The housing comprises a two part structure joined together in a plane substantially orthogonal to the exit path. The housing defines a substantially unobstructed cavity for receiving the device. The housing in the coupling zone defines a slot through which the exit path extends, the slot defining a restricted space for deployment of a capture device.

Abstract translation: 一种用于医疗设备的容器，所述医疗设备具有限定用于接收所述设备的空腔的外壳，所述空腔外部的联接区以及所述空腔和所述联接区之间的出口孔; 以及位于所述空腔内的支承表面，所述支承表面，出口孔和联接区限定出口路径，所述装置可沿着所述出口路径移动以从所述容器展开。 支承表面与出口孔间隔开并且与连接区域一起布置成使得出口路径基本上是直的。 该腔大致为圆柱形，并且支承表面，出口孔和联接区对齐，使得出口路径沿基本上与腔相切的方向延伸。 该壳体包括在基本垂直于出口路径的平面中连接在一起的两部分结构。 壳体限定用于接收装置的基本上无阻碍的空腔。 在联接区域中的外壳限定出口路径延伸穿过的狭槽，该狭槽限定用于展开捕捉设备的受限空间。