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    LUNG DEVICE WITH SEALING FEATURES
    2.
    发明申请
    LUNG DEVICE WITH SEALING FEATURES 审中-公开
    具有密封特征的肺部装置

    公开(公告)号：WO2006014568A2

    公开(公告)日：2006-02-09

    申请号：PCT/US2005/024173

    申请日：2005-07-08

    Applicant: PNEUMRX, INC. ,  MCGURK, Erin ,  MATHIS, Mark ,  DIECK, Ronald ,  WARTCHOW, Charles

    Inventor： MCGURK, Erin ,  MATHIS, Mark ,  DIECK, Ronald ,  WARTCHOW, Charles

    IPC: A61B17/08

    CPC classification number: A61B17/0057 ,  A61B17/00491 ,  A61B2017/0065 ,  A61B2017/00654

    Abstract: This invention relates generally to a design of lung devices for safely performing a transthoracic procedure. In particular, the invention provides devices and methods of using these devices to access the thoracic cavity with minimal risk of causing pneumothorax or hemothorax. More specifically, the invention enables diagnostic and therapeutic access to a thoracic cavity using large bore instruments. This invention also provides a method for diagnostic and therapeutic procedures using a device capable of sealing the wound upon withdrawal of the device. The invention includes a device comprising an elongated body adapted to make contact with a tissue of a subject through an access hole, and a sealant delivery element. The invention also includes a method of performing tissue treatment or diagnosis in a subject.

    Abstract translation: 本发明一般涉及用于安全地进行经胸手术的肺部装置的设计。 特别地，本发明提供了使用这些装置以最小的导致气胸或血胸风险的方式来接近胸腔的装置和方法。 更具体地，本发明使得能够使用大孔器械诊断和治疗进入胸腔。 本发明还提供了一种诊断和治疗方法，该方法使用能够在装置取出时密封伤口的装置。 本发明包括一种装置，包括适于通过进入孔与受试者的组织接触的细长主体和密封剂递送元件。 本发明还包括在受试者中进行组织治疗或诊断的方法。

    PLEURAL EFFUSION TREATMENT DEVICE, METHOD AND MATERIAL
    3.
    发明申请
    PLEURAL EFFUSION TREATMENT DEVICE, METHOD AND MATERIAL 审中-公开
    PLEURAL EFFUSION处理装置，方法和材料

    公开(公告)号：WO2006014567A2

    公开(公告)日：2006-02-09

    申请号：PCT/US2005024172

    申请日：2005-07-08

    Applicant: PNEUMRX INC ,  MCGURK ERIN ,  DIECK RONALD ,  WARTCHOW CHARLES ,  GONG GLEN ,  BALCETA JOBERT

    Inventor： MCGURK ERIN ,  DIECK RONALD ,  WARTCHOW CHARLES ,  GONG GLEN ,  BALCETA JOBERT

    IPC: A61B17/08

    CPC classification number: A61B17/00491 ,  A61B2017/00495 ,  A61M25/0041 ,  A61M25/0068 ,  A61M25/007 ,  A61M25/0074 ,  A61M31/00 ,  A61M2025/0073

    Abstract: The invention discloses a method of treating a patient for pleural effusion comprising percutaneously delivering an adhesive material to a pleural space of the patient. Suitable adhesive materials for performing any of the embodiments of the methods of the invention can be selected from the group consisting of hydrogels, collagen, poly(lactic acid), poly(glycolide), cyanoacrylates, glutaraldehyde, PEG, protein, and polysaccharide and derivatives thereof. The invention also discloses a pleural effusion treatment apparatus comprising an adhesive material adapted to adhere pleural membranes defining a pleural space and a pleural space access member adapted to deliver the adhesive material to the pleural space.

    Abstract translation: 本发明公开了一种治疗患者胸腔积液的方法，包括将粘合剂材料经皮递送至患者的胸膜腔。 用于实施本发明方法的任何实施方案的合适的粘合剂材料可以选自水凝胶，胶原，聚（乳酸），聚（乙交酯），氰基丙烯酸酯，戊二醛，PEG，蛋白质和多糖及衍生物 它们。 本发明还公开了一种胸腔积液治疗装置，其包括适于粘附限定胸膜腔的胸膜的粘合剂材料和适于将粘合剂材料输送到胸膜腔的胸膜空间进入构件。

    LUNG VOLUME REDUCTION APPARATUS AND METHODS
    4.
    发明申请
    LUNG VOLUME REDUCTION APPARATUS AND METHODS 审中-公开

    公开(公告)号：WO2019222741A1

    公开(公告)日：2019-11-21

    申请号：PCT/US2019/033123

    申请日：2019-05-20

    Applicant: PNEUMRX, INC.

    Inventor： RODRIGUEZ, Verna ,  HONG, Kinman

    IPC: A61B17/12 ,  A61B1/00 ,  A61B17/00 ,  A61B17/10 ,  A61F2/04

    Abstract: The invention provides improved medical devices, therapeutic treatment systems, and treatment methods for treatment of the lung. The invention includes methods, systems, and devices for applying a first lung volume reduction action to the functionally impaired lung tissue so as to reduce its volume to less than a pre-treatment volume; and applying a pro-inflammatory stimulus to the functionally impaired lung tissue having reduced volume, that stimulus being sufficient to induce fibrosis in the functionally impaired lung tissue. The pro-inflammatory stimulus may be separate and additional to that of the lung volume reduction action.

    INTRA-BRONCHIAL LUNG VOLUME REDUCTION SYSTEM
    6.
    发明申请
    INTRA-BRONCHIAL LUNG VOLUME REDUCTION SYSTEM 审中-公开
    INTRA-BRONCHIAL LUNG体积减少系统

    公开(公告)号：WO2006009688A3

    公开(公告)日：2009-04-09

    申请号：PCT/US2005020943

    申请日：2005-06-14

    Applicant: PNEUMRX INC ,  MCGURK ERIN ,  MATHIS MARK L ,  THOMPSON DAVE P ,  ARONSON NATHAN A

    Inventor： MCGURK ERIN ,  MATHIS MARK L ,  THOMPSON DAVE P ,  ARONSON NATHAN A

    IPC: A61B18/18 ,  A61B17/12 ,  A61B17/22 ,  A61M25/00 ,  A61M25/10 ,  A61M29/00

    CPC classification number: A61M25/0026 ,  A61B17/12104 ,  A61B17/12136 ,  A61B17/12186 ,  A61B2017/12054 ,  A61B2017/12095 ,  A61B2017/22067 ,  A61M25/0069 ,  A61M25/007 ,  A61M25/0075 ,  A61M25/10 ,  A61M25/1027 ,  A61M2025/1052 ,  A61M2025/1054 ,  A61M2210/1039

    Abstract: The invention provides devices and systems for treating lungs. One aspect of the invention provides a lung device with an expandable member having an open lumen formed therethrough, the expandable (e.g., inflatable and compliant) member having an expanded diameter adapted to contact a circumferential wall portion of a lung air passageway. The device may also include a plug adapted to close the open lumen and a coupler adapted to couple the plug and the 5E@0nd0bl5 member. Another aspect of the invention provides a lung device and delivery system including: an expandable member having an open lumen formed therethrough, the expandable member having an expanded diameter adapted to fit within a lung air passageway; and a delivery catheter adapted to deliver the expandable member to a lung air passageway, the delivery catheter having a coupler adapted to couple the catheter to the expandable member.

    Abstract translation: 本发明提供了用于治疗肺的装置和系统。 本发明的一个方面提供了一种具有可扩张构件的肺部装置，该可扩张构件具有穿过其形成的开口腔，该可膨胀（例如，可膨胀和柔顺）构件具有适于接触肺空气通道的周壁部分的扩张直径。 该装置还可以包括适于闭合开放的内腔的插头和适于联接插头和5E @ 0nd0b5构件的耦合器。 本发明的另一方面提供一种肺部装置和递送系统，包括：具有穿过其形成的开口的可扩张构件，所述可扩张构件具有适于装配在肺空气通道内的扩张直径; 以及适于将所述可扩张构件输送到肺空气通道的输送导管，所述输送导管具有适于将所述导管联接到所述可扩张构件的联接器。

    TARGETING DAMAGED LUNG TISSUE
    7.
    发明申请
    TARGETING DAMAGED LUNG TISSUE 审中-公开
    靶向破坏性肺组织

    公开(公告)号：WO2006009699A3

    公开(公告)日：2007-03-22

    申请号：PCT/US2005020993

    申请日：2005-06-13

    Applicant: PNEUMRX INC ,  GONG GLEN ,  DIECK RONALD

    Inventor： GONG GLEN ,  DIECK RONALD

    IPC: A61K38/00 ,  A61K49/00 ,  C12N9/66

    CPC classification number: A61K49/0008

    Abstract: The present invention relates to methods and compositions for targeting damaged lung tissue. Compositions provided feature a targeting moiety coupled to one or more other moieties, including, for example, a cross-linkable moiety, an imaging moiety, and/or one or more other targeting moieties. The methods and compositions of the invention find use, for example, in detecting and treating a pulmonary condition such as emphysema.

    Abstract translation: 本发明涉及用于靶向损伤的肺组织的方法和组合物。 提供的组合物具有与一个或多个其它部分偶联的靶向部分，包括例如可交联部分，成像部分和/或一个或多个其它靶向部分。 本发明的方法和组合物可用于例如检测和治疗诸如肺气肿的肺部疾病。

    PRE-TREATMENT PLANNING AND REAL-TIME VISUALIZATION OF LUNG VOLUME REDUCTION THERAPIES
    9.
    发明申请
    PRE-TREATMENT PLANNING AND REAL-TIME VISUALIZATION OF LUNG VOLUME REDUCTION THERAPIES 审中-公开

    公开(公告)号：WO2020081698A3

    公开(公告)日：2020-04-23

    申请号：PCT/US2019/056558

    申请日：2019-10-16

    Applicant: PNEUMRX, INC.

    Inventor： RODRIGUEZ, Verna

    IPC: A61B5/08 ,  A61B6/03 ,  G16H30/40

    Abstract: Systems and methods for developing a lung volume reduction treatment plan for a patient include developing a first personalized three-dimensional pulmonary model for the patient based on a computerized tomography (CT) scan of the lung of the patient and a validated computational pulmonary system model, selecting a first lung coil design and a first lung coil placement location, developing a second personalized three-dimensional pulmonary model for the patient based on the first personalized three-dimensional pulmonary model for the patient, the first lung coil design, and the first lung coil placement location, and selecting a second lung coil design and a second lung coil placement location, where the selection of the second lung coil placement location is based on the second personalized three-dimensional pulmonary model for the patient.

    PRE-TREATMENT PLANNING AND REAL-TIME VISUALIZATION OF LUNG VOLUME REDUCTION THERAPIES
    10.
    发明申请
    PRE-TREATMENT PLANNING AND REAL-TIME VISUALIZATION OF LUNG VOLUME REDUCTION THERAPIES 审中-公开

    公开(公告)号：WO2020081698A2

    公开(公告)日：2020-04-23

    申请号：PCT/US2019/056558

    申请日：2019-10-16

    Applicant: PNEUMRX, INC.

    Inventor： RODRIGUEZ, Verna

    IPC: G16H50/20

    Abstract: Systems and methods for developing a lung volume reduction treatment plan for a patient include developing a first personalized three-dimensional pulmonary model for the patient based on a computerized tomography (CT) scan of the lung of the patient and a validated computational pulmonary system model, selecting a first lung coil design and a first lung coil placement location, developing a second personalized three-dimensional pulmonary model for the patient based on the first personalized three-dimensional pulmonary model for the patient, the first lung coil design, and the first lung coil placement location, and selecting a second lung coil design and a second lung coil placement location, where the selection of the second lung coil placement location is based on the second personalized three-dimensional pulmonary model for the patient.

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