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    NOVEL SUBSTITUTED N, N-DIMETHYLAMINOALKYL ETHERS OF ISOFLAVANONE OXIMES AS Η1-RECEPTOR ANTAGONISTS
    1.
    发明申请
    NOVEL SUBSTITUTED N, N-DIMETHYLAMINOALKYL ETHERS OF ISOFLAVANONE OXIMES AS Η1-RECEPTOR ANTAGONISTS 审中-公开
    新西兰取代的N，N-二甲基氨基甲基异佛尔酮氧化物的亚型和受体拮抗剂

    公开(公告)号：WO2015047113A1

    公开(公告)日：2015-04-02

    申请号：PCT/PL2013/000126

    申请日：2013-09-30

    申请人： POLFARMEX S.A.

    发明人： KOPCZACKI, Piotr ,  WOŚKO, Mieczysław ,  WALCZAK, Jarosław ,  WALCZYŃSKI, Krzyszto

    IPC分类号： C07D311/68 ,  C07D407/04

    CPC分类号： C07D311/68 ,  A61K31/22 ,  C07D405/04 ,  C07D407/04

    摘要： The present invention relates to compounds of formula (I), and salts thereof and the pharmaceutical composition containing them in treatment of various diseases, as allergic rhinitis where R 1 and R 2 are, independently, hydrogen, halogen, C 1 _ 3 alkyl or C 1-3 alkoxy; R 3 is phenyl optionally substituted by R 4 and R 5 which are, independently hydrogen, halogen, C 1-3 alkyl, C1-3-alkoxy, fluoro-, difluoro- and trifluoromethyl, nitrile group, N,N-diC 1-3 alkyl- amide, carboC 1-3 alkoxy or C 1-3 alkylsulphone groups; R 3 is pyridyl group containing nitrogen at various positions in the benzene ring, n is one of the integers 1 or 2.

    摘要翻译： 本发明涉及式（I）化合物及其盐和其治疗各种疾病的药物组合物，作为过敏性鼻炎，其中R 1和R 2独立地为氢，卤素，C 1-3烷基或C 1-3烷氧基; R3是任选被R4和R5取代的苯基，其独立地是氢，卤素，C1-3烷基，C1-3烷氧基，氟 - ，二氟 - 和三氟甲基，腈基，N，N-二-C1-3烷基 - 酰胺，碳C1 -3烷氧基或C1-3烷基砜基; R3是在苯环中各个位置含有氮的吡啶基，n是整数1或2之一。