公开(公告)号：WO9728187A3

公开(公告)日：1997-10-23

申请号：PCT/US9701726

申请日：1997-01-29

Applicant: POPULATION COUNCIL INC

Inventor： FONTENOT JAMES DARRELL ,  PHILLIPS DAVID M

IPC: A61K38/00 ,  C07K14/47 ,  C07K16/10 ,  A61K39/395

CPC classification number: C07K14/4727 ,  A61K38/00 ,  C07K16/1063 ,  C07K2317/34 ,  C07K2319/00

Abstract: A proline rich, tandem repeat domain of human mucin MUC1 forms an extended structure containing large repeating loops that are crested by a turn. The repeating loop structure of MUC1 can be replaced by an Φ loop of an immunoglobulin-superfamily protein to create a chimeric, multivalent, mucin-like, compound. The mucin/Φ loop chimera retains the binding specificity of the parent immunoglobulin-superfamily protein. The design and construction of chimeric peptides are general, theoretically limited only by the size of the immunoglobulin superfamily. The peptides can be used for a variety of prophylactic and therapeutic applications.