公开(公告)号：WO2009024522A1

公开(公告)日：2009-02-26

申请号：PCT/EP2008/060664

申请日：2008-08-14

Applicant: PRECISENSE A/S ,  AASMUL, Søren

Inventor： AASMUL, Søren

IPC: A61M5/42 ,  A61M5/46 ,  B24B19/16 ,  A61M5/158 ,  A61M5/32

CPC classification number: A61M5/3286 ,  A61B5/14532 ,  A61B2560/063 ,  A61M5/158 ,  A61M5/3287 ,  A61M37/0069 ,  A61M2005/1581 ,  A61M2005/1585 ,  B24B19/16

Abstract: An injection apparatus for making an injection at a predetermined depth in skin comprises: a skin positioning member, an injection needle (610), and means guiding the injection needle for movement from a parking position above the skin beside said skin positioning member to slide beneath said skin positioning member to an injection position; wherein: the tip (620) of the injection needle is closer to the longitudinal axis of the shaft portion (650) than is the outside of the shaft portion (650) and/or the length of the lumen opening (625) of the needle is in a range from 5 to 15 times the diameter of the shaft (650) of the needle. An injection needle wherein the length of the lumen opening (625) of the needle is in a range from 5 to 15 times the diameter of the shaft (650) of the needle.

Abstract translation: 用于在皮肤中以预定深度进行注射的注射装置包括：皮肤定位构件，注射针（610），以及引导注射针从所述皮肤定位构件旁边的皮肤上方的停放位置移动的装置，以在下方滑动 所述皮肤定位部件到达注射位置; 其中：所述注射针的尖端（620）比所述轴部（650）的外侧更靠近所述轴部（650）的纵向轴线和/或所述针的内腔开口（625）的长度 在针的轴（650）的直径的5至15倍的范围内。 一种注射针，其中针的内腔开口（625）的长度在针的轴（650）的直径的5至15倍的范围内。

公开(公告)号：WO2005064318A1

公开(公告)日：2005-07-14

申请号：PCT/EP2004/014484

申请日：2004-12-20

Applicant: PRECISENSE A/S ,  AASMUL, Søren

Inventor： AASMUL, Søren

IPC: G01N21/64

CPC classification number: G01N21/645 ,  G01J1/04 ,  G01J1/0422 ,  G01N2021/6463 ,  G01N2201/0636

Abstract: In apparatus for the production and detection of fluorescence at a sample surface, the height of the apparatus above the sample surface is reduced, and loss of the emitted fluorescence due to reflection loss and light scattering is minimized. The apparatus comprises a three-dimensionally curved light reflecting surface (40) that directs light from a light source (32) transversely to its original path and focuses the light on to an illumination zone (30) at or below the sample surface. The reflecting surface (40) also collects, directs and at least partially collimates emitted fluorescence transversely to its original path and towards a detector (46).

Abstract translation: 在用于在样品表面生产和检测荧光的装置中，样品表面上方的装置的高度减小，并且由于反射损失和光散射引起的发射的荧光的损失最小化。 该装置包括三维弯曲的光反射表面（40），其将来自光源（32）的光横向于其原始路径引导并将光聚焦到在样品表面处或下方的照明区域（30）。 反射表面（40）还收集，引导并至少部分地将发射的荧光横向于其原始路径并朝向检测器（46）准直。

公开(公告)号：WO2006010604A1

公开(公告)日：2006-02-02

申请号：PCT/EP2005/008147

申请日：2005-07-27

Applicant: PRECISENSE A/S ,  AASMUL, Søren

Inventor： AASMUL, Søren

IPC: G01N21/64

CPC classification number: G01N21/6408 ,  G01J3/4406 ,  G01N21/274 ,  G01N21/6428 ,  G01N21/645 ,  G01N27/3271 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6441

Abstract: Apparatus for measuring a phase shift induced in a light signal has a first light source for emitting a light signal along a measurement optical path that includes a sample, for example a fluorescent sample, and a second light source for emitting a light signal along a dummy measurement optical path. A measurement electronic circuit is provided for receiving the light signals and providing outputs separated in time which are indicative of the phase of the respective light signals. In use, a phase shift is induced in light in the measurement optical path by the fluorescent sample. A reference electronic circuit is provided for receiving a signal. indicative of the phase of the light signals emitted by the first and second light sources. Circuitry is provided to compare the respective phases of light output from the two circuits to provide an output indicative of a first measured phase difference during operation of the first light source. A correction is then applied to this measurement by taking a similar phase difference measurement during operation of the second light source and comparing the two phase differences.

Abstract translation: 用于测量在光信号中感应的相移的装置具有第一光源，用于沿着包括样品例如荧光样品的测量光路发射光信号，以及用于沿虚拟物发射光信号的第二光源 测量光路。 提供了一种测量电子电路，用于接收光信号并提供时间上分离的指示相应光信号的相位的输出。 在使用中，通过荧光样品在测量光路中的光中引起相移。 提供用于接收信号的参考电子电路。 指示由第一和第二光源发射的光信号的相位。 提供电路以比较来自两个电路的光输出的各个相位，以提供指示在第一光源的操作期间的第一测量相位差的输出。 然后通过在第二光源的操作期间进行类似的相位差测量并比较两个相位差来对该测量进行校正。

公开(公告)号：WO2009024521A2

公开(公告)日：2009-02-26

申请号：PCT/EP2008/060662

申请日：2008-08-14

Applicant: PRECISENSE A/S ,  EJLERSEN, Henning, Munk ,  AASMUL, Søren

Inventor： EJLERSEN, Henning, Munk ,  AASMUL, Søren

IPC: A61M5/42 ,  A61M5/46 ,  B24B19/16 ,  A61M5/158 ,  A61M5/32

CPC classification number: A61M37/0069 ,  A61B5/14503 ,  A61B5/14532 ,  A61B5/6848 ,  A61B17/205 ,  A61M5/3286 ,  A61M5/3287 ,  A61M5/425 ,  A61M5/427 ,  A61M5/46 ,  A61M2005/1581 ,  A61M2005/1583 ,  A61M2005/1585 ,  A61M2205/195

Abstract: An injection apparatus for making an injection at a predetermined depth in skin comprises: a first skin positioning member; a second skin positioning member, wherein the first and second skin positioning members lie or are moveable to lie in an injection arrangement; an injection needle; and means guiding the injection needle for movement from a parking position above the skin, through the lower surface of the second skin positioning member to slide beneath the first skin positioning member to an injection position. A further injection apparatus comprises: an injection needle; a plunger within the injection needle; and means for retracting the injection needle such that material to be injected is expelled from the injection needle by the plunger.

Abstract translation: 用于在皮肤中以预定深度进行注射的注射装置包括：第一皮肤定位构件; 第二皮肤定位构件，其中所述第一和第二皮肤定位构件位于或可移动地位于注射装置中; 注射针 以及引导所述注射针从所述皮肤上方的停车位置移动通过所述第二皮肤定位构件的下表面，以在所述第一皮肤定位构件的下方滑动到注射位置。 另外的注射装置包括：注射针; 注射针内的柱塞; 以及用于缩回注射针的装置，使得待注射的材料被柱塞从注射针排出。