公开(公告)号：WO2018200722A1

公开(公告)日：2018-11-01

申请号：PCT/US2018/029436

申请日：2018-04-25

Applicant: PROTHERA BIOLOGICS, INC.

Inventor： LIM, Yow-Pin ,  SPERO, Denice

IPC: G01N33/53 ,  C12Q1/37 ,  C07K14/81

Abstract: Described herein are methods for quantifying lAIP levels in a sample (e.g., from a subject) using lAIP ligand-based assays. Also disclosed are methods for measuring lAIP-IAIP ligand complexes, and methods of evaluating, monitoring, and treating subjects using the aforementioned lAIP quantification methods.

公开(公告)号：WO2022104282A1

公开(公告)日：2022-05-19

申请号：PCT/US2021/059569

申请日：2021-11-16

Applicant: PROTHERA BIOLOGICS, INC.

Inventor： LIM, Yow-Pin ,  QIU, Joseph

IPC: G01N33/68 ,  A61K38/55

Abstract: Described herein are methods for purifying lαlp from a biological material using an endotoxin- binding agent. The method involves applying the biological material containing the lαlp to an endotoxin- binding agent, discarding the flow through, applying a wash buffer(s), and eluting the lαlp from the endotoxin-binding agent.

公开(公告)号：WO2020086879A1

公开(公告)日：2020-04-30

申请号：PCT/US2019/057911

申请日：2019-10-24

Applicant: PROTHERA BIOLOGICS, INC.

Inventor： LIM, Yow-Pin ,  SPERO, Denice ,  SANTOSO, Andre Richard

IPC: A61K9/00 ,  A61K38/57 ,  C07K14/81

Abstract: Featured are a foodstuff containing an inter-alpha inhibitor protein (lαlp) (e.g., lαl, Pαl, a heavy chain (e.g., H1, H2, H3, H4, and/or H5), a light chain (e.g., bikunin), or a combination thereof), methods of preparing a foodstuff containing an lαlp, and methods of treating and/or reducing the likelihood of developing a disease or condition (e.g., a disease or condition characterized by inflammation and/or low levels of an lαlp) in a subject in need thereof by administering a composition or a foodstuff containing an lαlp. Also featured are methods of purifying an lαlp (e.g., lαl, Pαl, a heavy chain (e.g., H1, H2, H3, H4, and/or H5), a light chain (e.g., bikunin), or a combination thereof) from milk.

公开(公告)号：WO2014113659A1

公开(公告)日：2014-07-24

申请号：PCT/US2014/012033

申请日：2014-01-17

Applicant: PROTHERA BIOLOGICS

Inventor： LIM, Yow-Pin

IPC: C07K1/14

CPC classification number: C07K1/14 ,  B01D15/08 ,  B01D15/363 ,  C07K1/16 ,  C07K1/18 ,  C07K1/36 ,  C07K14/47 ,  C07K14/75 ,  C07K14/755 ,  C07K14/76 ,  C07K14/78 ,  C07K14/81 ,  C07K14/8125 ,  C12N9/6462

Abstract: Described is a method for isolating multiple blood products from a single starting material. Isolation of multiple blood products from a single starting material maximizes the efficiency of blood product isolation. In the present invention, one or more blood products are isolated from a blood product material previously depleted of inter-alpha inhibitor protein (lαlp). This method provides new paths for increasing the efficiency of isolating blood components and providing pharmaceutically acceptable forms of those components.

Abstract translation: 描述了从单一起始材料中分离多种血液制品的方法。 从单一起始物质中分离出多种血液制品可最大限度地提高血液制品隔离效率。 在本发明中，从先前缺乏α型抑制蛋白（lαlp）的血液制品中分离出一种或多种血液制品。 该方法提供了增加分离血液成分的效率并提供这些组分的药学上可接受的形式的新途径。

公开(公告)号：WO2018053029A8

公开(公告)日：2018-03-22

申请号：PCT/US2017/051403

申请日：2017-09-13

Applicant: PROTHERA BIOLOGICS, INC.

Inventor： LIM, Yow-Pin ,  SPERO, Denice ,  ANDREWS, Richard

IPC: A61K38/57

Abstract: The invention features methods for treating or preventing pulmonary diseases, including acute respiratory distress syndrome (ARDS) and pneumonia, in a subject in need thereof that involve administering to the subject inter-alpha inhibitor proteins (lalps), including, e.g., inter-alpha inhibitor (lal) and/or pre-alpha inhibitor (Pal).

公开(公告)号：WO2018053029A1

公开(公告)日：2018-03-22

申请号：PCT/US2017/051403

申请日：2017-09-13

Applicant: PROTHERA BIOLOGICS, INC.

Inventor： LIM, Yow-Pin ,  SPERO, Denice ,  ANDREW, Richard

IPC: A61K38/57

Abstract: The invention features methods for treating or preventing pulmonary diseases, including acute respiratory distress syndrome (ARDS) and pneumonia, in a subject in need thereof that involve administering to the subject inter-alpha inhibitor proteins (lalps), including, e.g., inter-alpha inhibitor (lal) and/or pre-alpha inhibitor (Pal).

Abstract translation: 本发明的特征在于用于治疗或预防有此需要的受试者的肺部疾病（包括急性呼吸窘迫综合征（ARDS）和肺炎）的方法，所述方法涉及向受试者施用α-arrest抑制剂蛋白质（片段） ，包括例如α-α间抑制剂（Ile）和/或α前期抑制剂（Pal）。

公开(公告)号：WO2005046587A2

公开(公告)日：2005-05-26

申请号：PCT/US2004/036848

申请日：2004-11-05

Applicant: PROTHERA BIOLOGICS ,  LIM, Yow-Pin ,  JOSIC, Djuro ,  HIXSON, Douglas, C.

Inventor： LIM, Yow-Pin ,  JOSIC, Djuro ,  HIXSON, Douglas, C.

IPC: A61K

CPC classification number: C07K14/811 ,  A61K38/00 ,  B01D15/363 ,  B01D15/3804 ,  G01N30/96 ,  G01N33/566 ,  G01N2030/009 ,  G01N2333/81 ,  G01N2800/52

Abstract: The invention relates to Inter-alpha inhibitor proteins (IαIp). The invention further relates to processes for purification of IαIp compositions and their use for treatment of human diseases such as sepsis and septic shock, rheumatoid arthritis, cancer and infectious diseases.

Abstract translation: 本发明涉及α-1抑制蛋白（IαIp）。 本发明进一步涉及用于纯化IαIp组合物的方法及其用于治疗人类疾病例如脓毒症和感染性休克，类风湿性关节炎，癌症和感染性疾病的用途。