公开(公告)号：WO2022271731A1

公开(公告)日：2022-12-29

申请号：PCT/US2022/034383

申请日：2022-06-21

Applicant: RECURIUM IP HOLDINGS, LLC

Inventor： SAMATAR, Ahmed, Abdi ,  DONATE, Fernando ,  DE JONG, Petrus, Rudolf ,  ESCOUBET, Laure ,  LIU, Wen ,  PULTAR, Philippe ,  VOLIOTIS, Dimitrios ,  BUNKER, Kevin, Duane ,  HUANG, Peter, Qinhua

IPC: G01N33/543 ,  A61K31/519 ,  A61P35/00 ,  C12Q1/6886 ,  G01N33/574

Abstract: Disclosed herein is a method of determining subject sensitivity to a WEE1 inhibitor, comprising obtaining or having obtained a biological sample from the subject, and performing or having performed at least one assay on the biological sample to determine if the subject has an altered function of CCNE1. Also disclosed are methods of treating cancer with a WEE1 inhibitor, comprising identifying a subject having (a) the cancer and (b) endogenous or altered function of CCNE1; and administering an effective amount of the WEE1 inhibitor, or a pharmaceutically acceptable salt thereof, to the subject.

公开(公告)号：WO2023076485A1

公开(公告)日：2023-05-04

申请号：PCT/US2022/048037

申请日：2022-10-27

Applicant: RECURIUM IP HOLDINGS, LLC

Inventor： DONATE, Fernando ,  ESCOUBET, Laure ,  DE JONG, Petrus, Rudolf ,  IZADI, Hooman ,  SAMATAR, Ahmed, Abdi ,  BOREN, Brant, Clayton ,  BUNKER, Kevin, Duane ,  HUANG, Peter, Qinhua

IPC: A61K31/437 ,  A61K31/497 ,  A61K31/519 ,  A61P35/00

Abstract: Disclosed herein are combinations of compounds for treating diseases or conditions such as cancer. The combinations include a WEE1 inhibitor and a DDR inhibitor such as an ATR, ATM or CHK1 inhibitor.