公开(公告)号：WO2021127045A1

公开(公告)日：2021-06-24

申请号：PCT/US2020/065410

申请日：2020-12-16

Applicant: RECURIUM IP HOLDINGS, LLC

Inventor： SAMATAR, Ahmed Abdi ,  LI, Jiali ,  IZADI, Hooman ,  HUANG, Peter Qinhua ,  PINCHMAN, Joseph Robert ,  BOREN, Brant Clayton ,  BUNKER, Kevin Duane ,  DONATE, Fernando

IPC: A61K31/519 ,  A61P35/00

Abstract: Disclosed herein are combinations of compounds for treating a disease or condition, such as cancer. A combination of compounds for treating a disease or condition can include a Bcl-2 inhibitor and a WEE1 inhibitor, along with pharmaceutically acceptable salts of any of the foregoing.

公开(公告)号：WO2021231653A1

公开(公告)日：2021-11-18

申请号：PCT/US2021/032094

申请日：2021-05-12

Applicant: RECURIUM IP HOLDINGS, LLC

Inventor： SAMATAR, Ahmed, Abdi ,  LI, Jiali ,  HUANG, Peter, Qinhua ,  BUNKER, Kevin, Duane ,  DONATE, Fernando ,  BOREN, Brant, Clayton

IPC: C07D487/04 ,  C07D519/00 ,  A61K31/437 ,  A61K31/496 ,  A61K31/5355 ,  A61P35/00

Abstract: Disclosed herein are compounds and combinations of compounds for treating a disease or condition, such as cancer.

公开(公告)号：WO2021127042A1

公开(公告)日：2021-06-24

申请号：PCT/US2020/065407

申请日：2020-12-16

Applicant: RECURIUM IP HOLDINGS, LLC

Inventor： SAMATAR, Ahmed, Abdi ,  MA, Jianhui ,  LI, Jiali ,  IZADI, Hooman ,  HUANG, Peter, Qinhua ,  HEGDE, Sayee, Gajanan ,  PINCHMAN, Joseph, Robert ,  BUNKER, Kevin, Duane ,  DONATE, Fernando

IPC: A61K31/437 ,  A61K31/496 ,  A61P35/00

Abstract: Disclosed herein are combinations of compounds for treating a disease or condition, such as cancer. A combination of compounds for treating a disease or condition can include a SERD inhibitor and a Bcl-2 inhibitor, along with pharmaceutically acceptable salts of any of the foregoing.

公开(公告)号：WO2022082180A1

公开(公告)日：2022-04-21

申请号：PCT/US2021/071840

申请日：2021-10-13

Applicant: RECURIUM IP HOLDINGS, LLC

Inventor： SAMATAR, Ahmed, Abdi ,  DONATE, Fernando ,  IZADI, Hooman ,  PINCHMAN, Joseph, Robert ,  BUNKER, Kevin, Duane ,  HUANG, Peter, Qinhua

IPC: A61K31/496 ,  A61K31/5355 ,  A61K31/7068 ,  A61K31/4184 ,  A61K31/69 ,  A61P35/00 ,  A61P35/02

Abstract: The present invention relates to the combination of Bcl-2 inhibitor Compound (A) in combination with a chemotherapeutic agent Compound (B) selected from azacitidine, bendamustine, bortezomib, carfilzomib, ixazomib, busulfan, carboplatin, cytarabine, cyclophosphamide, cladribine, cisplatin, capecitabine, decitabine, etoposide, fludarabine, gemcitabine, daunorubicin, doxorubicin, ifosfamide, methotrexate and vincristine, or a pharmaceutically acceptable salt of any of the foregoing, for the treatment of a disease or condition in particular hematological cancers.

公开(公告)号：WO2021127047A1

公开(公告)日：2021-06-24

申请号：PCT/US2020/065415

申请日：2020-12-16

Applicant: RECURIUM IP HOLDINGS, LLC

Inventor： SAMATAR, Ahmed, Abdi ,  LI, Jiali ,  MA, Jianhui ,  HUANG, Peter, Qinhua ,  HEGDE, Sayee, Gajanan ,  BOREN, Brant, Clayton ,  BUNKER, Kevin, Duane ,  DONATE, Fernando

IPC: A61K31/519 ,  A61K31/437 ,  A61P35/00

Abstract: Disclosed herein are combinations of compounds for treating a disease or condition, such as cancer. A combination of compounds for treating a disease or condition can include a SERD inhibitor and a WEE1 inhibitor, along with pharmaceutically acceptable salts of any of the foregoing.

公开(公告)号：WO2021127039A1

公开(公告)日：2021-06-24

申请号：PCT/US2020/065401

申请日：2020-12-16

Applicant: RECURIUM IP HOLDINGS, LLC

Inventor： SAMATAR, Ahmed, Abdi ,  LI, Jiali ,  HUANG, Peter, Qinhua ,  BOREN, Brant, Clayton ,  BUNKER, Kevin, Duane ,  DONATE, Fernando

IPC: A61K31/519 ,  A61P35/00

Abstract: Disclosed herein are combinations of compounds for treating a disease or condition, such as cancer. A combination of compounds for treating a disease or condition can include a WEE1 inhibitor, and a SERD or SERM inhibitor, along with pharmaceutically acceptable salts of any of the foregoing.

公开(公告)号：WO2023064282A1

公开(公告)日：2023-04-20

申请号：PCT/US2022/046291

申请日：2022-10-11

Applicant: RECURIUM IP HOLDINGS, LLC

Inventor： DONATE, Fernando ,  IZADI, Hooman ,  SAMATAR, Ahmed, Abdi ,  BOREN, Brant Clayton ,  BUNKER, Kevin, Duane ,  HUANG, Peter, Qinhua

IPC: A61K31/522 ,  A61P35/00 ,  A61K39/00 ,  A61K39/395 ,  C07K16/28

Abstract: Disclosed herein are combinations of compounds for treating a disease or condition, such as cancer. The combinations can include a WEE1 inhibitor, such as ZN-c3, and an anti-CD47 antibody.

公开(公告)号：WO2022271731A1

公开(公告)日：2022-12-29

申请号：PCT/US2022/034383

申请日：2022-06-21

Applicant: RECURIUM IP HOLDINGS, LLC

Inventor： SAMATAR, Ahmed, Abdi ,  DONATE, Fernando ,  DE JONG, Petrus, Rudolf ,  ESCOUBET, Laure ,  LIU, Wen ,  PULTAR, Philippe ,  VOLIOTIS, Dimitrios ,  BUNKER, Kevin, Duane ,  HUANG, Peter, Qinhua

IPC: G01N33/543 ,  A61K31/519 ,  A61P35/00 ,  C12Q1/6886 ,  G01N33/574

Abstract: Disclosed herein is a method of determining subject sensitivity to a WEE1 inhibitor, comprising obtaining or having obtained a biological sample from the subject, and performing or having performed at least one assay on the biological sample to determine if the subject has an altered function of CCNE1. Also disclosed are methods of treating cancer with a WEE1 inhibitor, comprising identifying a subject having (a) the cancer and (b) endogenous or altered function of CCNE1; and administering an effective amount of the WEE1 inhibitor, or a pharmaceutically acceptable salt thereof, to the subject.

公开(公告)号：WO2022136916A1

公开(公告)日：2022-06-30

申请号：PCT/IB2021/000891

申请日：2021-12-17

Applicant: RECURIUM IP HOLDINGS, LLC

Inventor： PULTAR, Philippe ,  VOLIOTIS, Dimitrios ,  TOLCHER, Anthony, William ,  SUN, Anthony, Ya-Ning ,  DONATE, Fernando ,  RUDOLF DE JONG, Petrus ,  SAMATAR, Ahmed, Abdi ,  BUNKER, Kevin, Duane ,  HUANG, Peter, Qinhua

IPC: C12Q1/6886 ,  C12Q1/6827 ,  A61P35/00 ,  A61K31/519 ,  G01N33/50

Abstract: Disclosed herein is a method of determining subject sensitivity to a WEE1 inhibitor, comprising obtaining or having obtained a biological sample from the subject, and performing or having performed at least one assay on the biological sample to determine if the subject has an altered DNA repair function of NBN, MRE11, RAD50 or MRE11-RAD50-NBN (MRN) protein complex. Also disclosed are methods of treating cancer with WEE1 inhibitors, and modifying the effective concentration based upon the sequence variation and function of NBN, MRE11, RAD50 or MRE11-RAD50-NBN (MRN) protein complex.

公开(公告)号：WO2022133446A1

公开(公告)日：2022-06-23

申请号：PCT/US2021/072921

申请日：2021-12-14

Applicant: RECURIUM IP HOLDINGS, LLC

Inventor： BUNKER, Kevin, Duane ,  SAMATAR, Ahmed, Abdi ,  DONATE, Fernando ,  MA, Jianhui ,  IZADI, Hooman ,  PINCHMAN, Joseph, Robert ,  HUANG, Peter, Qinhua

IPC: A61K31/496 ,  A61K31/437 ,  A61K31/519 ,  A61P35/00

Abstract: Disclosed herein are combinations of compounds for treating a disease or condition, such as cancer. A combination of compounds for treating a disease or condition can include a Bcl-2 inhibitor, a SERD inhibitor, and a CDK4/6 inhibitor, along with pharmaceutically acceptable salts of any of the foregoing.