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    MULTISPECIFIC ANTIGEN-BINDING MOLECULES AND USES THEREOF
    2.
    发明申请
    MULTISPECIFIC ANTIGEN-BINDING MOLECULES AND USES THEREOF 审中-公开

    公开(公告)号：WO2017007796A4

    公开(公告)日：2017-01-12

    申请号：PCT/US2016/041055

    申请日：2016-07-06

    Applicant: REGENERON PHARMACEUTICALS, INC.

    Inventor： ANDREEV, Julian ,  THAMBI, Nithya ,  DELFINO, Frank ,  MARTIN, Joel ,  THURSTON, Gavin ,  CYGNAR, Katherine ,  PAPADOPOULOS, Nicholas

    IPC: C07K16/28 ,  C07K16/46 ,  C07K16/22 ,  C07K16/12 ,  C07K16/32 ,  C07K16/18 ,  C07K14/435 ,  A61K47/48

    Abstract: The present disclosure provides multispecific antigen-binding molecules and uses thereof. The multispecific antigen-binding molecules comprise a first antigen-binding domain that specifically binds a target molecule, and a second antigen-binding domain that specifically binds an internalizing effector protein. The multispecific antigen-binding molecules of the present disclosure can, in some embodiments, be bispecific antibodies that are capable of binding both a target molecule and an internalizing effector protein. In certain embodiments of the disclosure, the simultaneous binding of the target molecule and the internalizing effector protein by the multispecific antigen-binding molecule of the present disclosure results in the attenuation of the activity of the target molecule to a greater extent than the binding of the target molecule alone. In other embodiments of the disclosure, the target molecule is a tumor associated antigen, and the simultaneous binding of the tumor associated antigen and the internalizing effector protein by the multispecific antigen-binding molecule of the present disclosure causes or facilitates the targeted killing of tumor cells.

    ANTIBODIES, AND BISPECIFIC ANTIGEN-BINDING MOLECULES THAT BIND HER2 AND/OR APLP2, CONJUGATES, AND USES THEREOF
    3.
    发明申请
    ANTIBODIES, AND BISPECIFIC ANTIGEN-BINDING MOLECULES THAT BIND HER2 AND/OR APLP2, CONJUGATES, AND USES THEREOF 审中-公开

    公开(公告)号：WO2019212965A1

    公开(公告)日：2019-11-07

    申请号：PCT/US2019/029640

    申请日：2019-04-29

    Applicant: REGENERON PHARMACEUTICALS, INC.

    Inventor： PEREZ BAY, Andres ,  ANDREEV, Julian ,  POTOCKY, Terra ,  DUAN, Xunbao

    IPC: C07K16/28 ,  C07K16/32 ,  A61P35/00 ,  A61K47/68

    Abstract: The protein known as human epidermal growth factor 2 (HER2) is expressed in breast cancer cells and its expression is correlated with aggressive tumor growth. The present invention provides novel full-length human (IgG) antibodies that bind to human HER2 (monospecific antibodies) or to APLP2 (monospecific antibodies). The present invention also provides novel bispecific antibodies (bsAbs) that bind to both HER2 and APLP2 and mediate internalization and degradation of HER2 via the APLP2 complex in the presence of HER2-expressing tumors. Described are bispecific antigen-binding molecules and ADCs comprising a first antigen-binding domain that specifically binds human APLP2, and a second antigen-binding domain that specifically binds human HER2. The described bispecific ADCs are capable of inhibiting the growth of certain tumors expressing HER2 and may be useful for the treatment of breast cancer and disorders in which targeting a therapeutic agent to HER2-expressing tumor cell is desirable and/or therapeutically beneficial. For example, the bispecific antibodies of the invention are useful for the treatment of breast cancers, including breast cancers having a IHC2+ classification. The present invention also includes anti-HER2 antibody drug conjugates which inhibit tumor growth in vivo .

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